Open Access

Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions

  • Authors:
    • Efthimios Dardiotis
    • Vasileios Siokas
    • Antonios Garas
    • Evangelos Paraskevaidis
    • Maria Kyrgiou
    • Georgia Xiromerisiou
    • Efthimios Deligeoroglou
    • Georgios Galazios
    • Emmanuel N. Kontomanolis
    • Demetrios A. Spandidos
    • Aristidis Tsatsakis
    • Alexandros Daponte
  • View Affiliations

  • Published online on: July 6, 2018     https://doi.org/10.3892/ol.2018.9104
  • Pages: 3833-3841
  • Copyright: © Dardiotis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Human papillomavirus (HPV) infection alone is not sufficient to explain the development of cervical cancer. Genetic variants have been linked to the development of precancerous lesions and cervical cancer. In this study, we aimed to evaluate the association of 10 single nucleotide polymorphisms (SNPs) of the Fas cell surface death receptor (FAS), trinucleotide repeat containing 6C (TNRC6C), transmembrane channel like 8 (TMC8), DNA meiotic recombinase 1 (DMC1), deoxyuridine triphosphatase (DUT), sulfatase 1 (SULF1), 2'-5-oligoadenylate synthetase 3 (OAS3), general transcription factor IIH subunit 4 (GTF2H4) and interferon gamma (IFNG) genes with susceptibility to precancerous lesions and cervical cancer. In total, 608 female participants, consisting of 199 patients with persistent low-grade precancerous lesions (CIN1), 100 with high-grade precancerous lesions (CIN2/3), 17 patients with cervical cancer and 292 healthy controls, were enrolled in this study. SNPs were tested for associations with each of the above-mentioned cervical group lesions or when considering an overall patient group. A significant difference for rs4737999 was observed between the controls and the overall patient group considering the recessive mode of inheritance [odds ratio (OR), 0.48; 95% confidence interval (CI), 0.24-0.96; P=0.033]. This effect was even stronger on the risk of CIN1 lesions. Carriers of the rs4737999 AA genotype were almost 3-fold less likely of having low grade lesions compared to the other genotypes. On the whole, this study provides evidence of an influence of the SULF1 gene rs4737999 SNP in the development of precancerous lesions/cervical cancer.
View Figures
View References

Related Articles

Journal Cover

September-2018
Volume 16 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Dardiotis E, Siokas V, Garas A, Paraskevaidis E, Kyrgiou M, Xiromerisiou G, Deligeoroglou E, Galazios G, Kontomanolis EN, Spandidos DA, Spandidos DA, et al: Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions. Oncol Lett 16: 3833-3841, 2018
APA
Dardiotis, E., Siokas, V., Garas, A., Paraskevaidis, E., Kyrgiou, M., Xiromerisiou, G. ... Daponte, A. (2018). Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions. Oncology Letters, 16, 3833-3841. https://doi.org/10.3892/ol.2018.9104
MLA
Dardiotis, E., Siokas, V., Garas, A., Paraskevaidis, E., Kyrgiou, M., Xiromerisiou, G., Deligeoroglou, E., Galazios, G., Kontomanolis, E. N., Spandidos, D. A., Tsatsakis, A., Daponte, A."Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions". Oncology Letters 16.3 (2018): 3833-3841.
Chicago
Dardiotis, E., Siokas, V., Garas, A., Paraskevaidis, E., Kyrgiou, M., Xiromerisiou, G., Deligeoroglou, E., Galazios, G., Kontomanolis, E. N., Spandidos, D. A., Tsatsakis, A., Daponte, A."Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions". Oncology Letters 16, no. 3 (2018): 3833-3841. https://doi.org/10.3892/ol.2018.9104