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Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions

  • Authors:
    • Efthimios Dardiotis
    • Vasileios Siokas
    • Antonios Garas
    • Evangelos Paraskevaidis
    • Maria Kyrgiou
    • Georgia Xiromerisiou
    • Efthimios Deligeoroglou
    • Georgios Galazios
    • Emmanuel N. Kontomanolis
    • Demetrios A. Spandidos
    • Aristidis Tsatsakis
    • Alexandros Daponte
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, 41100 Larissa, Greece, Department of Obstetrics and Gynecology, University Hospital of Larissa, 41100 Larissa, Greece, Division of Obstetrics-Gynaecology, University Hospital of Ioannina, 45501 Ioannina, Greece, Department of Surgery and Cancer, IRDB, Imperial College London, London W120NN, UK, Division of Pediatric-Adolescent Gynecology and Reconstructive Surgery, 2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Medical School, ‘Aretaieion’ Hospital, 11528 Athens, Greece, Department of Obstetrics/Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece, Laboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece
    Copyright: © Dardiotis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3833-3841
    |
    Published online on: July 6, 2018
       https://doi.org/10.3892/ol.2018.9104
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Abstract

Human papillomavirus (HPV) infection alone is not sufficient to explain the development of cervical cancer. Genetic variants have been linked to the development of precancerous lesions and cervical cancer. In this study, we aimed to evaluate the association of 10 single nucleotide polymorphisms (SNPs) of the Fas cell surface death receptor (FAS), trinucleotide repeat containing 6C (TNRC6C), transmembrane channel like 8 (TMC8), DNA meiotic recombinase 1 (DMC1), deoxyuridine triphosphatase (DUT), sulfatase 1 (SULF1), 2'-5-oligoadenylate synthetase 3 (OAS3), general transcription factor IIH subunit 4 (GTF2H4) and interferon gamma (IFNG) genes with susceptibility to precancerous lesions and cervical cancer. In total, 608 female participants, consisting of 199 patients with persistent low-grade precancerous lesions (CIN1), 100 with high-grade precancerous lesions (CIN2/3), 17 patients with cervical cancer and 292 healthy controls, were enrolled in this study. SNPs were tested for associations with each of the above-mentioned cervical group lesions or when considering an overall patient group. A significant difference for rs4737999 was observed between the controls and the overall patient group considering the recessive mode of inheritance [odds ratio (OR), 0.48; 95% confidence interval (CI), 0.24-0.96; P=0.033]. This effect was even stronger on the risk of CIN1 lesions. Carriers of the rs4737999 AA genotype were almost 3-fold less likely of having low grade lesions compared to the other genotypes. On the whole, this study provides evidence of an influence of the SULF1 gene rs4737999 SNP in the development of precancerous lesions/cervical cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Dardiotis E, Siokas V, Garas A, Paraskevaidis E, Kyrgiou M, Xiromerisiou G, Deligeoroglou E, Galazios G, Kontomanolis EN, Spandidos DA, Spandidos DA, et al: Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions. Oncol Lett 16: 3833-3841, 2018.
APA
Dardiotis, E., Siokas, V., Garas, A., Paraskevaidis, E., Kyrgiou, M., Xiromerisiou, G. ... Daponte, A. (2018). Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions. Oncology Letters, 16, 3833-3841. https://doi.org/10.3892/ol.2018.9104
MLA
Dardiotis, E., Siokas, V., Garas, A., Paraskevaidis, E., Kyrgiou, M., Xiromerisiou, G., Deligeoroglou, E., Galazios, G., Kontomanolis, E. N., Spandidos, D. A., Tsatsakis, A., Daponte, A."Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions". Oncology Letters 16.3 (2018): 3833-3841.
Chicago
Dardiotis, E., Siokas, V., Garas, A., Paraskevaidis, E., Kyrgiou, M., Xiromerisiou, G., Deligeoroglou, E., Galazios, G., Kontomanolis, E. N., Spandidos, D. A., Tsatsakis, A., Daponte, A."Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions". Oncology Letters 16, no. 3 (2018): 3833-3841. https://doi.org/10.3892/ol.2018.9104
Copy and paste a formatted citation
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Spandidos Publications style
Dardiotis E, Siokas V, Garas A, Paraskevaidis E, Kyrgiou M, Xiromerisiou G, Deligeoroglou E, Galazios G, Kontomanolis EN, Spandidos DA, Spandidos DA, et al: Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions. Oncol Lett 16: 3833-3841, 2018.
APA
Dardiotis, E., Siokas, V., Garas, A., Paraskevaidis, E., Kyrgiou, M., Xiromerisiou, G. ... Daponte, A. (2018). Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions. Oncology Letters, 16, 3833-3841. https://doi.org/10.3892/ol.2018.9104
MLA
Dardiotis, E., Siokas, V., Garas, A., Paraskevaidis, E., Kyrgiou, M., Xiromerisiou, G., Deligeoroglou, E., Galazios, G., Kontomanolis, E. N., Spandidos, D. A., Tsatsakis, A., Daponte, A."Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions". Oncology Letters 16.3 (2018): 3833-3841.
Chicago
Dardiotis, E., Siokas, V., Garas, A., Paraskevaidis, E., Kyrgiou, M., Xiromerisiou, G., Deligeoroglou, E., Galazios, G., Kontomanolis, E. N., Spandidos, D. A., Tsatsakis, A., Daponte, A."Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions". Oncology Letters 16, no. 3 (2018): 3833-3841. https://doi.org/10.3892/ol.2018.9104
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