si‑TP73‑AS1 suppressed proliferation and increased the chemotherapeutic response of GC cells to cisplatin

Peng,Jianjun

doi:10.3892/ol.2018.9107

si‑TP73‑AS1 suppressed proliferation and increased the chemotherapeutic response of GC cells to cisplatin

Authors:
- Jianjun Peng
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Affiliations: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China
Published online on: July 10, 2018 https://doi.org/10.3892/ol.2018.9107
Pages: 3706-3714
Copyright: © Peng . This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Previous studies have revealed that long noncoding RNAs (lncRNAs) function as crucial regulators in various biological processes, including tumorigenesis. Although the expression of lncRNA TP73‑antisense RNA1 (AS1) has been identified in hepatocellular carcinoma and glioma, the biological function of TP73‑AS1 in gastric cancer (GC) remains unclear. Thus, the present study employed a comprehensive analysis on the function of lncRNA TP73‑AS1 in GC. The aim of the present study was to determine the clinical significance and biological function of TP73‑AS1 in human GC tissues and cells. Additionally, the expression of TP73‑AS1 was increased in GC tissues and cell lines and increased expression level of TP73‑AS1 was associated with poor prognosis in patients with GC. Functional assays revealed that silencing of TP73‑AS1 may suppress cell proliferation and enhance the chemotherapeutic response of GC cells to cisplatin through targeting the high mobility group 1/receptor for advanced glycation endproducts signaling pathway. Collectively, the results of the present study demonstrated that TP73‑AS1 may be a novel lncRNA for the clinical prognosis of GC and a potential therapeutic target for the treatment of GC.

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