Neoangiogenesis of gastric submucosa‑invasive adenocarcinoma

Sasaki,Hanae; Morohashi,Satoko; Toba,Takahito; Seino,Hiroko; Yoshizawa,Tadashi; Hirai,Hideaki; Haga,Toshihiro; Wu,Yunyan; Kijima,Hiroshi

doi:10.3892/ol.2018.9116

September-2018 Volume 16 Issue 3

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

September-2018 Volume 16 Issue 3

Full Size Image

Article Open Access

Neoangiogenesis of gastric submucosa‑invasive adenocarcinoma

Authors:
- Hanae Sasaki
- Satoko Morohashi
- Takahito Toba
- Hiroko Seino
- Tadashi Yoshizawa
- Hideaki Hirai
- Toshihiro Haga
- Yunyan Wu
- Hiroshi Kijima
View Affiliations / Copyright

Affiliations: School of Medicine, Hirosaki University, Hirosaki, Aomori, 036-8560, Japan, Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan, Department of Internal Medicine, Toho University Ohmori Medical Center, Ohta, Tokyo 143‑8541, Japan

Copyright: © Sasaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 3895-3900
|
Published online on: July 10, 2018

https://doi.org/10.3892/ol.2018.9116
Expand metrics +

Abstract

Early gastric cancer may be defined as mucosal or submucosal invasive carcinoma, and exhibits a good prognosis: 90% of patients survive >10 years. Early gastric cancer infrequently exhibits lymph node metastasis, although submucosal invasion, the presence of vascular invasion and/or lymphatic permeation are independent risk factors for lymph node metastasis in early gastric cancer. The analysis of tumor lymphangiogenesis and angiogenesis are important to determine the extent of invasive progression and metastasis in patients. Previously, the presence of vessels expressing the D2‑40 antibody and the factor‑VIII protein has been identified immunohistochemically. The vessels that are immunoreactive for D2‑40 and factor‑VIII are morphologically similar to lymphatic vessels or small‑size veins, also termed venules. In the present study, the association between tumor invasion and neoangiogenesis in early gastric cancer was examined. The D2‑40/factor‑VIII double‑stained vessel (DSV) density was analyzed, in addition to lymphatic and blood vessel (vein and artery) density, using 46 submucosa‑invasive and 50 mucosal carcinomas, and 20 non‑neoplastic gastric tissues. The lymphatic density and DSV density of submucosa beneath the carcinoma and submucosa of the surrounding region in submucosa‑invasive carcinoma were significantly increased (P<0.001) in comparison with those in mucosal carcinoma or non‑neoplastic gastric tissue. No significant difference was observed in blood vessel density between non‑neoplastic gastric, mucosal carcinoma and submucosa‑invasive carcinoma tissues other than that of mucosa. The present study suggests the potential for the presence of D2‑40/factor‑VIII DSV and the importance of this vessel for neoangiogenesis in early gastric cancer.

View Figures

View References

1	Tsukuma H, Mishima T and Oshima A: Prospective study of ‘early’ gastric cancer. Int J Cancer. 31:421–426. 1983. View Article : Google Scholar : PubMed/NCBI
2	Bogomoletz WV: Early gastric cancer. Am J Surg Pathol. 8:381–391. 1984. View Article : Google Scholar : PubMed/NCBI
3	Kidokoro T: Frequency of resection, metastasis, and five year survival rate of early gastric carcinoma in a surgical clinic: Early Gastric Cancer. Japanese Scientific Press; pp. 43–49. 1971
4	Fielding JW, Ellis DJ, Jones BG, Paterson J, Powell DJ, Waterhouse JA and Brookes VS: Natural history of ‘early’ gastric cancer: results of a 10-year regional survey. Br Med J. 281:965–957. 1981. View Article : Google Scholar
5	Lauwers GY, Carneiro F, Graham DY, Curado MP, Franceschi S, Montgomery E, Tatematsu M and Hattori T: Gastric carcinomaWHO Classification of Tumours of the Digestive System. 4th edition. Bosman FT, Carneiro F, Hruban RH and Theise ND: World Health Organization; Switzerland: pp. 48–58. 2010
6	Lee K, do Park J, Choe G, Kim HH, Kim WH and Lee HS: Increased intratumoral lymphatic vessel density correlates with lymph node metastasis in early gastric carcinoma. Ann Surg Oncol. 17:73–80. 2010. View Article : Google Scholar : PubMed/NCBI
7	Gao P, Zhou GY, Zhang QH, Xiang L, Zhang SL, Li C and Sun YL: Clinicopathological significance of peritumoral lymphatic vessel density in gastric carcinoma. Cancer Lett. 263:223–230. 2008. View Article : Google Scholar : PubMed/NCBI
8	Nakamura Y, Yasuoka H, Tsujimoto M, Kurozumi K, Nakahara M, Nakao K and Kakudo K: Importance of lymph vessels in gastric cancer: A prognostic indicator in general and a predictor for lymph node metastasis in early stage cancer. J Clin Pathol. 59:77–82. 2006. View Article : Google Scholar : PubMed/NCBI
9	Tomoda M, Maehara Y, Kakeji Y, Ohno S, Ichiyoshi Y and Sugimachi K: Intratumoral neovascularization and growth pattern in early gastric carcinoma. Cancer. 85:2340–2346. 1999. View Article : Google Scholar : PubMed/NCBI
10	Association] JGC: Japanese Classification of Gastric Carcinoma. Kanehara Press Inc; Tokyo: 2010
11	Murakami T: Pathomorphological diagnosis. Definition and gloss classification of early gastric cancer. Gann Monogr Cancer Res. 11:53–55. 1971.
12	Xuan ZX, Ueyama T, Yao T and Tsuneyoshi M: Time trends of early gastric carcinoma. A clinicopathologic analysis of 2846 cases. Cancer. 72:2889–2894. 1993. View Article : Google Scholar : PubMed/NCBI
13	Rasband WS: Image J. US National Institutes of Health; Bethesda, MD: 1997–2016, https://imagej.nih.gov/ij/
14	Abramoff MD, Magelhaes PJ and Ram SJ: Image processing with imagej. Biophotonics Int. 11:36–42. 2004.
15	Listorom MB and Fenoglio-Preiser CM: Lymphatic distribution of the stomach in normal, inflammatory, hyperplastic, and neoplastic tissue. Gastroenterology. 93:506–514. 1987. View Article : Google Scholar : PubMed/NCBI
16	Maeda K, Chung YS, Takatsuka S, Ogawa Y, Onoda N, Sawada T, Kato Y, Nitta A, Arimoto Y and Kondo Y: Tumour angiogenesis and tumour cell proliferation as prognostic indicators in gastric carcinoma. Br J Cancer. 72:319–323. 1995. View Article : Google Scholar : PubMed/NCBI
17	Tanigawa N, Amaya H, Matsumura M and Shimomatsuya T: Association of tumour vasculature with tumour progression and overall survival of patients with non-early gastric carcinomas. Br J Cancer. 75:566–571. 1997. View Article : Google Scholar : PubMed/NCBI
18	Xiangming C, Hokita S, Natsugoe S, Tanabe G, Baba M, Takao S, Kuroshima K and Aikou T: Angiogenesis as an unfavorable factor related to lymph node metastasis in early gastric cancer. Ann Surg Oncol. 5:585–589. 1998. View Article : Google Scholar : PubMed/NCBI
19	Kahn HJ, Bailey D and Marks A: Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Mod Pathol. 15:434–440. 2002. View Article : Google Scholar : PubMed/NCBI
20	Jaffe EA, Hoyer LW and Nachman RL: Synthesis of von Willebrand factor by cultured human endothelial cells. Proc Natl Acad Sci USA. 71:1906–1909. 1974. View Article : Google Scholar : PubMed/NCBI
21	Nachman R, Levine R and Jaffe EA: Synthesis of factor VIII antigen by cultured guinea pig megakaryocytes. J Clin Invest. 60:914–921. 1977. View Article : Google Scholar : PubMed/NCBI
22	Nachman RL and Jaffe EA: Subcellular platelet factor VIII antigen and von Willebrand factor. J Exp Med. 141:1101–1113. 1975. View Article : Google Scholar : PubMed/NCBI
23	Hoyer LW, De los Santos RP and Hoyer JR: Antihemophilic factor antigen. Localization in endothelial cells by immunofluorescent microscopy. J Clin Invest. 52:2737–2744. 1973. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Neoangiogenesis of gastric submucosa‑invasive adenocarcinoma

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Related Articles