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Article

LncRNA ATB promotes the proliferation and metastasis of lung cancer via activation of the p38 signaling pathway

  • Authors:
    • Lei Wei
    • Tao Wu
    • Ping He
    • Jun‑Lei Zhang
    • Wei Wu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, Southwest Hospital, Chongqing 400038, P.R. China, Stem Cell and Developmental Biology Laboratory, Department of Histology and Embryology, Third Military Medical University, Chongqing 400038, P.R. China
  • Pages: 3907-3912
    |
    Published online on: July 10, 2018
       https://doi.org/10.3892/ol.2018.9117
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Abstract

Long non‑coding RNA (lncRNA) activated by TGF‑β (ATB) has been reported to be widely expressed in different types of cancer; however, the function of ATB in lung cancer remains unclear. In order to elucidate the role of ATB in lung cancer, reverse transcription‑quantitative polymerase chain reaction was used to detect the expression of ATB in tumor tissues and corresponding non‑tumor lung tissues from 32 patients with lung cancer. Furthermore, the association between the expression of ATB and clinical characteristics was investigated. Cell proliferation was assessed using a cell counting kit‑8 assay and cell migration was assessed using a wound healing assays. Epithelial‑mesenchymal‑transition and mitogen‑activated protein kinase signaling pathway activity was examined using western blotting. It was demonstrated that ATB was highly expressed in lung cancer tissues compared with noncancerous tissues, and associated with tumor size and metastasis. It was also demonstrated that ATB was highly expressed in the lung cancer cell lines, A549 and HCC827, compared with the HBE‑1 cell line. Suppression of ATB significantly inhibited the proliferation and migratory rate of lung cancer cells. The protein expression levels of p38, E‑cadherin and N‑cadherin were altered by suppression of ATB expression. Overall, the present study demonstrated that ATB may promote the development of lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wei L, Wu T, He P, Zhang JL and Wu W: LncRNA ATB promotes the proliferation and metastasis of lung cancer via activation of the p38 signaling pathway. Oncol Lett 16: 3907-3912, 2018.
APA
Wei, L., Wu, T., He, P., Zhang, J., & Wu, W. (2018). LncRNA ATB promotes the proliferation and metastasis of lung cancer via activation of the p38 signaling pathway. Oncology Letters, 16, 3907-3912. https://doi.org/10.3892/ol.2018.9117
MLA
Wei, L., Wu, T., He, P., Zhang, J., Wu, W."LncRNA ATB promotes the proliferation and metastasis of lung cancer via activation of the p38 signaling pathway". Oncology Letters 16.3 (2018): 3907-3912.
Chicago
Wei, L., Wu, T., He, P., Zhang, J., Wu, W."LncRNA ATB promotes the proliferation and metastasis of lung cancer via activation of the p38 signaling pathway". Oncology Letters 16, no. 3 (2018): 3907-3912. https://doi.org/10.3892/ol.2018.9117
Copy and paste a formatted citation
x
Spandidos Publications style
Wei L, Wu T, He P, Zhang JL and Wu W: LncRNA ATB promotes the proliferation and metastasis of lung cancer via activation of the p38 signaling pathway. Oncol Lett 16: 3907-3912, 2018.
APA
Wei, L., Wu, T., He, P., Zhang, J., & Wu, W. (2018). LncRNA ATB promotes the proliferation and metastasis of lung cancer via activation of the p38 signaling pathway. Oncology Letters, 16, 3907-3912. https://doi.org/10.3892/ol.2018.9117
MLA
Wei, L., Wu, T., He, P., Zhang, J., Wu, W."LncRNA ATB promotes the proliferation and metastasis of lung cancer via activation of the p38 signaling pathway". Oncology Letters 16.3 (2018): 3907-3912.
Chicago
Wei, L., Wu, T., He, P., Zhang, J., Wu, W."LncRNA ATB promotes the proliferation and metastasis of lung cancer via activation of the p38 signaling pathway". Oncology Letters 16, no. 3 (2018): 3907-3912. https://doi.org/10.3892/ol.2018.9117
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