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Article

Proteins involved in cutaneous basal cell carcinoma development

  • Authors:
    • Magdalena Ciążyńska
    • Igor A. Bednarski
    • Karolina Wódz
    • Paweł Kolano
    • Joanna Narbutt
    • Michał Sobjanek
    • Anna Woźniacka
    • Aleksandra Lesiak
  • View Affiliations / Copyright

    Affiliations: Department of Proliferative Diseases, Regional Oncology Centre, Łódź 93‑513, Poland, Department of Dermatology, Paediatric Dermatology and Dermatological Oncology, Medical University of Łódź, Łódź 91‑347, Poland, Department of Experimental Immunology, Medical University of Łódź, Łódź 90‑237, Poland, Department of General and Oncological Surgery, Tomaszow Health Centre, Tomaszow Mazowiecki 97‑200, Poland, Department of Dermatology, Venereology and Allergy, Medical University of Gdansk, Gdansk 80‑210, Poland, Department of Dermatology and Venereology, Medical University of Łódź, Łódź 90‑647, Poland
  • Pages: 4064-4072
    |
    Published online on: July 11, 2018
       https://doi.org/10.3892/ol.2018.9126
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Abstract

Basal cell carcinoma (BCC) is the most common skin malignancy type in the Caucasian population, with a continuously increasing incidence rate. The etiology of BCC remains unknown, but it appears to have a multifactorial origin resulting from intrinsic and extrinsic factors, including short‑wavelength ultraviolet B radiation. The role of specific proteins in BCC that are known to be responsible for the regulation of cell division and are involved in skin aging, including transforming growth factor (TGF)‑β, Smad2, matrix metalloproteinases (MMPs)‑1, ‑3, ‑8 and ‑9, cathepsin‑K and progerin, remains unknown. The aim of the present study was to assess the mRNA and protein expression profile of samples with diagnosed nodular BCC (nBCC) compared with that of healthy skin samples collected from matched areas. The study group included 22 patients (10 men and 12 women; mean age, 59 years; range, 44‑82 years) with pathologically confirmed nBCC, and 22 healthy volunteers (10 men and 12 women; mean age, 59 years; range, 43‑78 years) as a control group. The expression of the studied proteins was assessed in all samples by western blotting and reverse transcription‑quantitative polymerase chain reaction analysis. Statistically significant increases in the expression of TGF‑β, Smad2, cathepsin‑K, progerin and MMP‑1, ‑3, ‑8 and ‑9 were detected in skin biopsies with diagnosed nBCC compared with the control group, confirming the important role of these proteins in skin carcinogenesis.
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View References

1 

Lesiak A, Slowik-Rylska M, Rogowski-Tylman M, Sysa-Jedrzejowska A, Norval M and Narbutt J: Risk factors in Central Poland for the development of superficial and nodular basal cell carcinomas. Arch Med Sci. 6:270–275. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Tilli CM, Van Steensel MA, Krekels GA, Neumann HA and Ramaekers FC: Molecular aetiology and pathogenesis of basal cell carcinoma. Br J Dermatol. 152:1108–1124. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Miller DL and Weinstock MA: Nonmelanoma skin cancer in the United States: Incidence. J Am Acad Dermatol. 30:774–778. 1994. View Article : Google Scholar : PubMed/NCBI

4 

Daya-Grosjean L and Couvé-Privat S: Sonic hedgehog signaling in basal cell carcinomas. Cancer Lett. 225:181–192. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Dessinioti C, Antoniou C, Katsambas A and Stratigos AJ: Basal cell carcinoma: Whats new under the sun. Photochem Photobiol. 86:481–491. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Corona R, Dogliotti E, DErrico M, Sera F, Iavarone I, Baliva G, Chinni LM, Gobello T, Mazzanti C, Puddu P and Pasquini P: Risk factors for basal cell carcinoma in a Mediterranean population: Role of recreational sun exposure early in life. Arch Dermatol. 137:1162–1168. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Green A, Battistutta D, Hart V, Leslie D and Weedon D: Skin cancer in a subtropical Australian population: Incidence and lack of association with occupation. The Nambour Study Group. Am J Epidemiol. 144:1034–1040. 1996. View Article : Google Scholar : PubMed/NCBI

8 

Gallagher RP and Lee TK: Adverse effects of ultraviolet radiation: A brief review. Prog Biophys Mol Biol. 92:119–131. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Oberyszyn TM: Non-melanoma skin cancer: Importance of gender, immunosuppressive status and vitamin D. Cancer Lett. 261:127–136. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Lupi O: Correlations between the Sonic Hedgehog Pathway and basal cell carcinoma. Int J Dermatol. 46:1113–1117. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Siegel PM and Massagué J: Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer. 3:807–820. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Yucel T, Mutnal A, Fay K, Fligiel SE, Wang T, Johnson T, Baker SR and Varani J: Matrix metalloproteinase expression in basal cell carcinoma: Relationship between enzyme profile and collagen fragmentation pattern. Exp Mol Pathol. 79:151–160. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Poswar FO, Fraga CA, Farias LC, Feltenberger JD, Cruz VP, Santos SH, Silveira CM, de Paula AM and Guimarães AL: Immunohistochemical analysis of TIMP-3 and MMP-9 in actinic keratosis, squamous cell carcinoma of the skin, and basal cell carcinoma. Pathol Res Pract. 209:705–709. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Quintanilla-Dieck MJ, Codriansky K, Keady M, Bhawan J and Rünger TM: Cathepsin K in melanoma invasion. J Invest Dermatol. 128:2281–2288. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Ishida M, Kojima F and Okabe H: Cathepsin-K expression in basal cell carcinoma. J Eur Acad Dermatology Venereol. 27:e128–e130. 2013. View Article : Google Scholar

16 

Yan X, Takahara M, Xie L, Oda Y, Nakahara T, Uchi H, Takeuchi S, Tu Y, Moroi Y and Furue M: Stromal expression of cathepsin-K in squamous cell carcinoma. J Eur Acad Dermatology Venereol. 25:362–365. 2011. View Article : Google Scholar

17 

McClintock D, Ratner D, Lokuge M, Owens DM, Gordon LB, Collins FS and Djabali K: The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin. PLoS One. 2:e12692007. View Article : Google Scholar : PubMed/NCBI

18 

Zuber TJ: Punch biopsy of the skin. Am Fam Physician. 65(1155–1158): 1161–1162, 1164. 2002.

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Ting PT, Kasper R and Arlette JP: Metastatic basal cell carcinoma: Report of two cases and literature review. J Cutan Med Surg. 9:10–15. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Han G and Wang XJ: Roles of TGFβ signaling Smads in squamous cell carcinoma. Cell Biosci. 2011(1): 412011. View Article : Google Scholar

22 

Cui W, Fowlis DJ, Bryson S, Duffie E, Ireland H, Balmain A and Akhurst RJ: TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell. 86:531–542. 1996. View Article : Google Scholar : PubMed/NCBI

23 

Stalińska L and Ferenc T: The role of TGF-beta in cell cycle regulation. Postepy Hig Med Dosw (Online). 59:441–449. 2005.(In Polish). PubMed/NCBI

24 

Bierie B and Moses HL: Tumour microenvironment: TGFbeta: The molecular Jekyll and Hyde of cancer. Nat Rev Cancer. 6:506–520. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Hata A, Shi Y and Massagué J: TGF-beta signaling and cancer: Structural and functional consequences of mutations in Smads. Mol Med Today. 4:257–262. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Li AG, Lu SL, Han G, Kulesz-Martin M and Wang XJ: Current view of the role of transforming growth factor beta 1 in skin carcinogenesis. J Investig Dermatol Symp Proc. 10:110–117. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Schmid P, Itin P and Rufli T: In situ analysis of transforming growth factors-beta (TGF-beta 1, TGF-beta 2, TGF-beta 3) and TGF-beta type II receptor expression in basal cell carcinomas. Br J Dermatol. 134:1044–1051. 1996. View Article : Google Scholar : PubMed/NCBI

28 

Gambichler T, Skrygan M, Kaczmarczyk JM, Hyun J, Tomi NS, Sommer A, Bechara FG, Boms S, Brockmeyer NH, Altmeyer P and Kreuter A: Increased expression of TGF-beta/Smad proteins in basal cell carcinoma. Eur J Med Res. 12:509–514. 2007.PubMed/NCBI

29 

Furue M, Kato M, Nakamura K, Nashiro K, Kikuchi K, Okochi H, Miyazono K and Tamaki K: Dysregulated expression of transforming growth factor beta and its type-I and type-II receptors in basal-cell carcinoma. Int J Cancer. 71:505–509. 1997. View Article : Google Scholar : PubMed/NCBI

30 

Witek K, Goździalska A and Jaśkiewicz J: Metaloproteinazy jako nowy wskaźnik diagnostyczny nowotworów skóry. Stan skóry wykładnikiem stanu zdrowia. (red.) Anna Goździalska, Jerzy Jaśkiewicz. Kraków: Oficyna Wydawnicza AFM. 19–29. 2012.

31 

Śliwowska I and Kopczyński Z: Metaloproteinazy macierzy zewnątrzkomórkowej-charakterystyka biochemiczna i kliniczna wartość oznaczania u chorych na raka piersi. Wsp Onkol. 9:327–335. 2005.(In Polish).

32 

Lukaszewicz-Zajac M, Mroczko B and Szmitkowski M: The significance of metalloproteinases and their inhibitors in gastric cancer. Postepy Hig Med Dosw (Online). 63:258–265. 2009.(In Polish). PubMed/NCBI

33 

Groblewska M, Mroczko B and Szmitkowski M: The role of selected matrix metalloproteinases and their inhibitors in colorectal cancer development. Postepy Hig Med Dosw (Online). 64:22–30. 2010.(In Polish). PubMed/NCBI

34 

Kwiatkowski P: The role of matrix metalloproteinases in tumour invasion. Pol Ann Med. 43–50. 2008.

35 

Wyględowska-Kania M, Gola J, Fila-Daniłow A, Wcisło-Dziadecka D, Brzezińska-Wcisło L and Mazurek U: Molecular studies of non-melanoma skin cancers. Borgis-Postępy Nauk Med. 752–757. 2012.

36 

Monhian N, Jewett BS, Baker SR and Varani J: Matrix metalloproteinase expression in normal skin associated with basal cell carcinoma and in distal skin from the same patients. Arch Facial Plast Surg. 7:238–243. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Varani J, Hattori Y, Chi Y, Schmidt T, Perone P, Zeigler ME, Fader DJ and Johnson TM: Collagenolytic and gelatinolytic matrix metalloproteinases and their inhibitors in basal cell carcinoma of skin: Comparison with normal skin. Br J Cancer. 82:657–665. 2000. View Article : Google Scholar : PubMed/NCBI

38 

Gutiérrez-Fernández A, Fueyo A, Folgueras AR, Garabaya C, Pennington CJ, Pilgrim S, Edwards DR, Holliday DL, Jones JL, Span PN, et al: Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion. Cancer Res. 68:2755–2763. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Goździalska Anna, Gawędzka Anna, Brzewski Paweł and Anna Wojas-Pelc JJ: Skin cancer diagnosis based on the determination of the expression metalloproteinases. Interdescyplinarne aspekty Nauk o zdrowiu. 41–56. 2010.

40 

Rao Q, Wang Y, Xia QY, Shi SS, Shen Q, Tu P, Shi QL, Zhou XJ and Wu B: Cathepsin-K in the immunohistochemical diagnosis of melanocytic lesions. Int J Clin Exp Pathol. 7:1132–1139. 2014.PubMed/NCBI

41 

Zheng Y, Chen H, Lai W, Xu Q, Liu C, Wu L and Maibach HI: Cathepsin D repairing role in photodamaged skin barrier. Skin Pharmacol Physiol. 28:97–102. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Prokocimer M, Davidovich M, Nissim-Rafinia M, Wiesel-Motiuk N, Bar DZ, Barkan R, Meshorer E and Gruenbaum Y: Nuclear lamins: Key regulators of nuclear structure and activities. J Cell Mol Med. 13:1059–1085. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Venables RS, McLean S, Luny D, Moteleb E, Morley S, Quinlan RA, Lane EB and Hutchison CJ: Expression of individual lamins in basal cell carcinomas of the skin. Br J Cancer. 84:512–519. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Oguchi M, Sagara J, Matsumoto K, Saida T and Taniguchi S: Expression of lamins depends on epidermal differentiation and transformation. Br J Dermatol. 147:853–858. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Tilli CM, Ramaekers FC, Broers JL, Hutchison CJ and Neumann HA: Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma. Br J Dermatol. 148:102–109. 2003. View Article : Google Scholar : PubMed/NCBI

46 

Scaffidi P and Misteli T: Lamin A-dependent nuclear defects in human aging. Science. 312:1059–1063. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Lin W, Huang J, Yuan Z, Feng S, Xie Y and Ma W: Protein kinase C inhibitor chelerythrine selectively inhibits proliferation of triple-negative breast cancer cells. Sci Rep. 7:20222017. View Article : Google Scholar : PubMed/NCBI

48 

Baudhuin M, Lamoureux F, Jacques C, Calleja Rodriguez L, Quillard T, Charrier C, Amiaud J, Berreur M, Brounais-LeRoyer B, Owen R, et al: Inhibition of BET proteins and epigenetic signaling as a potential treatment for osteoporosis. Bone. 94:10–21. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ciążyńska M, Bednarski IA, Wódz K, Kolano P, Narbutt J, Sobjanek M, Woźniacka A and Lesiak A: Proteins involved in cutaneous basal cell carcinoma development. Oncol Lett 16: 4064-4072, 2018.
APA
Ciążyńska, M., Bednarski, I.A., Wódz, K., Kolano, P., Narbutt, J., Sobjanek, M. ... Lesiak, A. (2018). Proteins involved in cutaneous basal cell carcinoma development. Oncology Letters, 16, 4064-4072. https://doi.org/10.3892/ol.2018.9126
MLA
Ciążyńska, M., Bednarski, I. A., Wódz, K., Kolano, P., Narbutt, J., Sobjanek, M., Woźniacka, A., Lesiak, A."Proteins involved in cutaneous basal cell carcinoma development". Oncology Letters 16.3 (2018): 4064-4072.
Chicago
Ciążyńska, M., Bednarski, I. A., Wódz, K., Kolano, P., Narbutt, J., Sobjanek, M., Woźniacka, A., Lesiak, A."Proteins involved in cutaneous basal cell carcinoma development". Oncology Letters 16, no. 3 (2018): 4064-4072. https://doi.org/10.3892/ol.2018.9126
Copy and paste a formatted citation
x
Spandidos Publications style
Ciążyńska M, Bednarski IA, Wódz K, Kolano P, Narbutt J, Sobjanek M, Woźniacka A and Lesiak A: Proteins involved in cutaneous basal cell carcinoma development. Oncol Lett 16: 4064-4072, 2018.
APA
Ciążyńska, M., Bednarski, I.A., Wódz, K., Kolano, P., Narbutt, J., Sobjanek, M. ... Lesiak, A. (2018). Proteins involved in cutaneous basal cell carcinoma development. Oncology Letters, 16, 4064-4072. https://doi.org/10.3892/ol.2018.9126
MLA
Ciążyńska, M., Bednarski, I. A., Wódz, K., Kolano, P., Narbutt, J., Sobjanek, M., Woźniacka, A., Lesiak, A."Proteins involved in cutaneous basal cell carcinoma development". Oncology Letters 16.3 (2018): 4064-4072.
Chicago
Ciążyńska, M., Bednarski, I. A., Wódz, K., Kolano, P., Narbutt, J., Sobjanek, M., Woźniacka, A., Lesiak, A."Proteins involved in cutaneous basal cell carcinoma development". Oncology Letters 16, no. 3 (2018): 4064-4072. https://doi.org/10.3892/ol.2018.9126
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