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Article

HIV positivity may not have a negative impact on survival in Epstein‑Barr virus‑positive Hodgkin lymphoma: A Japanese nationwide retrospective survey

  • Authors:
    • Mihoko Yotsumoto
    • Yoshikazu Ito
    • Shotaro Hagiwara
    • Yasuhito Terui
    • Hirokazu Nagai
    • Yasunori Ota
    • Atsushi Ajisawa
    • Tomoko Uehira
    • Junko Tanuma
    • Kazuma Ohyashiki
    • Seiji Okada
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Tokyo Medical University Hospital, Shinjuku‑ku, Tokyo 160‑0023, Japan, Department of Hematology, Tokyo Medical University Hospital, Shinjuku‑ku, Tokyo 160‑0023, Japan, Department of Hematology, Tokyo Women's Medical University Hospital, Shinjuku‑ku, Tokyo 162‑8666, Japan, Department of Hematology Oncology, Cancer Institute Hospital of JFCR, Koto‑ku, Tokyo 135‑8550, Japan, Department of Hematology, National Hospital Organization Nagoya Medical Center, Nagoya‑shi, Aichi 460‑0001, Japan, Department of Pathology, Teikyo University Hospital, Minato‑ku, Tokyo 173‑0003, Japan, Department of Infectious Diseases, Tokyo Metropolitan Toshima Hospital, Itabashi‑ku, Tokyo 173‑0015, Japan, Department of Infectious Diseases, National Hospital Organization Osaka National Hospital, Chuo‑ku, Osaka 540‑0006, Japan, AIDS Clinical Center, National Center for Global Health and Medicine, Shinjuku‑ku, Tokyo 162‑8655, Japan, Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, Chuo‑ku, Kumamoto 860‑8556, Japan
  • Pages: 3923-3928
    |
    Published online on: July 11, 2018
       https://doi.org/10.3892/ol.2018.9132
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Abstract

There has been no comparative clinical study focused on differences in the clinical features of Epstein‑Barr virus (EBV)+ Hodgkin lymphoma (HL) between HIV‑positive and ‑negative cases. In a nationwide survey from 511 institutions in Japan, the present study investigated 16 EBV+ HIVpositive HL patients. To further clarify their characteristics in comparison with EBV+ HIVnegative HL (n=34) in the combination antiretroviral therapy era in Japan, the present study was performed. Results indicated that EBV+ HIVpositive HL frequently occurred in a younger population compared with EBV+ HIVnegative HL (P=0.0295), and that the EBV+ HIVpositive HL group was not associated with the nodular sclerosis subtype in the population who were below the age of 40. Notably, the EBV+ HIVpositive HL group had a significantly higher frequency of extra‑nodal involvement (P=0.0214), including marrow invasion. In the advanced stage, 80% of those with EBV+ HIVpositive HL did not require dose‑reduction and in the majority of cases, chemotherapy was completed. There were no significant differences in the complete remission rate (P=0.1961), overall survival (P=0.200) and progression‑free survival (P=0.245) between EBV+ HIVpositive HL (median observational period, 23.5 months) and EBV+ HIVnegative HL (median observational period, 64.5 months), suggesting that HIV positivity may not have a negative impact on the clinical outcome of EBV+ HL. Notably, standard chemotherapy is effective and tolerable for EBV+ HL, regardless of HIV infection.
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Copy and paste a formatted citation
Spandidos Publications style
Yotsumoto M, Ito Y, Hagiwara S, Terui Y, Nagai H, Ota Y, Ajisawa A, Uehira T, Tanuma J, Ohyashiki K, Ohyashiki K, et al: HIV positivity may not have a negative impact on survival in Epstein‑Barr virus‑positive Hodgkin lymphoma: A Japanese nationwide retrospective survey. Oncol Lett 16: 3923-3928, 2018.
APA
Yotsumoto, M., Ito, Y., Hagiwara, S., Terui, Y., Nagai, H., Ota, Y. ... Okada, S. (2018). HIV positivity may not have a negative impact on survival in Epstein‑Barr virus‑positive Hodgkin lymphoma: A Japanese nationwide retrospective survey. Oncology Letters, 16, 3923-3928. https://doi.org/10.3892/ol.2018.9132
MLA
Yotsumoto, M., Ito, Y., Hagiwara, S., Terui, Y., Nagai, H., Ota, Y., Ajisawa, A., Uehira, T., Tanuma, J., Ohyashiki, K., Okada, S."HIV positivity may not have a negative impact on survival in Epstein‑Barr virus‑positive Hodgkin lymphoma: A Japanese nationwide retrospective survey". Oncology Letters 16.3 (2018): 3923-3928.
Chicago
Yotsumoto, M., Ito, Y., Hagiwara, S., Terui, Y., Nagai, H., Ota, Y., Ajisawa, A., Uehira, T., Tanuma, J., Ohyashiki, K., Okada, S."HIV positivity may not have a negative impact on survival in Epstein‑Barr virus‑positive Hodgkin lymphoma: A Japanese nationwide retrospective survey". Oncology Letters 16, no. 3 (2018): 3923-3928. https://doi.org/10.3892/ol.2018.9132
Copy and paste a formatted citation
x
Spandidos Publications style
Yotsumoto M, Ito Y, Hagiwara S, Terui Y, Nagai H, Ota Y, Ajisawa A, Uehira T, Tanuma J, Ohyashiki K, Ohyashiki K, et al: HIV positivity may not have a negative impact on survival in Epstein‑Barr virus‑positive Hodgkin lymphoma: A Japanese nationwide retrospective survey. Oncol Lett 16: 3923-3928, 2018.
APA
Yotsumoto, M., Ito, Y., Hagiwara, S., Terui, Y., Nagai, H., Ota, Y. ... Okada, S. (2018). HIV positivity may not have a negative impact on survival in Epstein‑Barr virus‑positive Hodgkin lymphoma: A Japanese nationwide retrospective survey. Oncology Letters, 16, 3923-3928. https://doi.org/10.3892/ol.2018.9132
MLA
Yotsumoto, M., Ito, Y., Hagiwara, S., Terui, Y., Nagai, H., Ota, Y., Ajisawa, A., Uehira, T., Tanuma, J., Ohyashiki, K., Okada, S."HIV positivity may not have a negative impact on survival in Epstein‑Barr virus‑positive Hodgkin lymphoma: A Japanese nationwide retrospective survey". Oncology Letters 16.3 (2018): 3923-3928.
Chicago
Yotsumoto, M., Ito, Y., Hagiwara, S., Terui, Y., Nagai, H., Ota, Y., Ajisawa, A., Uehira, T., Tanuma, J., Ohyashiki, K., Okada, S."HIV positivity may not have a negative impact on survival in Epstein‑Barr virus‑positive Hodgkin lymphoma: A Japanese nationwide retrospective survey". Oncology Letters 16, no. 3 (2018): 3923-3928. https://doi.org/10.3892/ol.2018.9132
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