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Correlation between CT features and liver function and p53expression in hepatitis, cirrhosis and hepatocellular carcinoma

  • Authors:
    • Yahui Hu
    • Jing Wu
    • Sha Li
    • Xiaoxiao Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450000, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4297-4302
    |
    Published online on: July 12, 2018
       https://doi.org/10.3892/ol.2018.9144
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Abstract

This study aimed to investigate the correlation between CT features and liver function and p53 expression in hepatitis, cirrhosis and hepatocellular carcinoma (HCC). Forty patients with HCC, 30 patients with cirrhosis and 30 patients with chronic hepatitis were enrolled between December, 2015 and December, 2016. At the same time, normal liver tissues collected from 30 patients with hepatic hemangioma were used as the normal control group. All the patients were scanned by CT. Average body surface area, left outer lobe and caudate lobe volume, and the proportions of left outer lobe and caudate lobe to the whole liver were calculated. Biochemical indexes of liver function were determined. The pathological tissues of all the subjects were analyzed. Compared with the control group, total liver volume of the HCC group was significantly reduced (P<0.05). Compared with the HCC group, the volume of the left outer lobe increased in the hepatitis group and the cirrhosis group. Compared with control group, caudate lobe volume increased significantly in the hepatitis group (P<0.05). Compared with the control group, the volume of the left outer lobe and the proportion of caudate lobe to the whole liver volume was significantly increased in all three groups (P<0.05). Liver function‑related indicators in the HCC and cirrhosis groups were significantly different from those in the control group (P<0.05). The expression level of p53 in HCC was significantly higher than that in the control group (P<0.05). The accuracy of diagnosis by using both p53 and CT was higher than the use of p53 or CT alone. CT can accurately measure the volume of each lobe of the liver, and p53 has important clinical values in the diagnosis of liver diseases. Thus, the reasonable combination of the two can effectively improve the diagnostic accuracy.
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Copy and paste a formatted citation
Spandidos Publications style
Hu Y, Wu J, Li S and Zhao X: Correlation between CT features and liver function and p53expression in hepatitis, cirrhosis and hepatocellular carcinoma. Oncol Lett 16: 4297-4302, 2018.
APA
Hu, Y., Wu, J., Li, S., & Zhao , X. (2018). Correlation between CT features and liver function and p53expression in hepatitis, cirrhosis and hepatocellular carcinoma. Oncology Letters, 16, 4297-4302. https://doi.org/10.3892/ol.2018.9144
MLA
Hu, Y., Wu, J., Li, S., Zhao , X."Correlation between CT features and liver function and p53expression in hepatitis, cirrhosis and hepatocellular carcinoma". Oncology Letters 16.4 (2018): 4297-4302.
Chicago
Hu, Y., Wu, J., Li, S., Zhao , X."Correlation between CT features and liver function and p53expression in hepatitis, cirrhosis and hepatocellular carcinoma". Oncology Letters 16, no. 4 (2018): 4297-4302. https://doi.org/10.3892/ol.2018.9144
Copy and paste a formatted citation
x
Spandidos Publications style
Hu Y, Wu J, Li S and Zhao X: Correlation between CT features and liver function and p53expression in hepatitis, cirrhosis and hepatocellular carcinoma. Oncol Lett 16: 4297-4302, 2018.
APA
Hu, Y., Wu, J., Li, S., & Zhao , X. (2018). Correlation between CT features and liver function and p53expression in hepatitis, cirrhosis and hepatocellular carcinoma. Oncology Letters, 16, 4297-4302. https://doi.org/10.3892/ol.2018.9144
MLA
Hu, Y., Wu, J., Li, S., Zhao , X."Correlation between CT features and liver function and p53expression in hepatitis, cirrhosis and hepatocellular carcinoma". Oncology Letters 16.4 (2018): 4297-4302.
Chicago
Hu, Y., Wu, J., Li, S., Zhao , X."Correlation between CT features and liver function and p53expression in hepatitis, cirrhosis and hepatocellular carcinoma". Oncology Letters 16, no. 4 (2018): 4297-4302. https://doi.org/10.3892/ol.2018.9144
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