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18F‑FDG PET/CT for the early prediction of the response rate and survival of patients with recurrent or metastatic breast cancer

  • Authors:
    • Feng‑Chun Zhang
    • Hai‑Yan Xu
    • Jian‑Jun Liu
    • Yuan‑Fan Xu
    • Bin Chen
    • Yi‑Jin Yang
    • Ning‑Ning Yan
    • Shao‑Li Song
    • Yu‑Mei Lin
    • Ying‑Chun Xu
  • View Affiliations / Copyright

    Affiliations: Oncology Department, Suzhou Kowloon Hospital, Shanghai Jiao Tong University, School of Medicine, Suzhou, Jiangsu 215021, P.R. China, Nuclear Medicine Department, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200127, P.R. China, Nuclear Medicine Department, Suzhou Kowloon Hospital, Shanghai Jiao Tong University, School of Medicine, Suzhou, Jiangsu 215021, P.R. China, Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, P.R. China, Department of Oncology, China‑Japan Union Hospital, Jilin University, Changchun, Jilin 130021, P.R. China, Department of Oncology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200127, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4151-4158
    |
    Published online on: July 16, 2018
       https://doi.org/10.3892/ol.2018.9151
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Abstract

The present study aimed to explore the value of fludeoxyglucose F 18 positron emission tomography‑computed tomography (PET/CT) for the early prediction of chemotherapy remission rates and survival in patients with recurrent and metastatic breast cancer. A total of 24 patients diagnosed with recurrent or metastatic breast cancer between 2009 and 2014 were enrolled. All patients underwent a PET/CT examination prior to (PET/CT1) and following (PET/CT2) chemotherapy. Differences of PET/CT1 maximal standardized uptake values (SUVmax), PET/CT2 SUVmax, ΔSUVmax and the ΔSUVmax% between objective remission (OR) and non‑OR groups were measured. Survival differences between OR and non‑OR groups and the overall survival (OS) between metabolic responsive and metabolic non‑responsive groups were analyzed. In the present study, it was revealed that ΔSUVmax and ΔSUVmax% were significantly higher in the OR group compared with the non‑OR group (P<0.001). Overall survival was significantly prolonged in the OR and metabolic responder groups compared with their respective control groups (P<0.001 and P<0.01, respectively). ΔSUVmax% were significantly positively associated with OS (r2=0.266; P<0.01). In conclusion, PET/CT may be valuable for the early prediction of the chemotherapy efficacy and survival of patients with recurrent or metastatic breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang FC, Xu HY, Liu JJ, Xu YF, Chen B, Yang YJ, Yan NN, Song SL, Lin YM, Xu YC, Xu YC, et al: 18F‑FDG PET/CT for the early prediction of the response rate and survival of patients with recurrent or metastatic breast cancer. Oncol Lett 16: 4151-4158, 2018.
APA
Zhang, F., Xu, H., Liu, J., Xu, Y., Chen, B., Yang, Y. ... Xu, Y. (2018). 18F‑FDG PET/CT for the early prediction of the response rate and survival of patients with recurrent or metastatic breast cancer. Oncology Letters, 16, 4151-4158. https://doi.org/10.3892/ol.2018.9151
MLA
Zhang, F., Xu, H., Liu, J., Xu, Y., Chen, B., Yang, Y., Yan, N., Song, S., Lin, Y., Xu, Y."18F‑FDG PET/CT for the early prediction of the response rate and survival of patients with recurrent or metastatic breast cancer". Oncology Letters 16.4 (2018): 4151-4158.
Chicago
Zhang, F., Xu, H., Liu, J., Xu, Y., Chen, B., Yang, Y., Yan, N., Song, S., Lin, Y., Xu, Y."18F‑FDG PET/CT for the early prediction of the response rate and survival of patients with recurrent or metastatic breast cancer". Oncology Letters 16, no. 4 (2018): 4151-4158. https://doi.org/10.3892/ol.2018.9151
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang FC, Xu HY, Liu JJ, Xu YF, Chen B, Yang YJ, Yan NN, Song SL, Lin YM, Xu YC, Xu YC, et al: 18F‑FDG PET/CT for the early prediction of the response rate and survival of patients with recurrent or metastatic breast cancer. Oncol Lett 16: 4151-4158, 2018.
APA
Zhang, F., Xu, H., Liu, J., Xu, Y., Chen, B., Yang, Y. ... Xu, Y. (2018). 18F‑FDG PET/CT for the early prediction of the response rate and survival of patients with recurrent or metastatic breast cancer. Oncology Letters, 16, 4151-4158. https://doi.org/10.3892/ol.2018.9151
MLA
Zhang, F., Xu, H., Liu, J., Xu, Y., Chen, B., Yang, Y., Yan, N., Song, S., Lin, Y., Xu, Y."18F‑FDG PET/CT for the early prediction of the response rate and survival of patients with recurrent or metastatic breast cancer". Oncology Letters 16.4 (2018): 4151-4158.
Chicago
Zhang, F., Xu, H., Liu, J., Xu, Y., Chen, B., Yang, Y., Yan, N., Song, S., Lin, Y., Xu, Y."18F‑FDG PET/CT for the early prediction of the response rate and survival of patients with recurrent or metastatic breast cancer". Oncology Letters 16, no. 4 (2018): 4151-4158. https://doi.org/10.3892/ol.2018.9151
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