Open Access

Serum ProGRP and NSE levels predicting small cell lung cancer transformation in a patient with ALK rearrangement‑positive non‑small cell lung cancer: A case report

  • Authors:
    • Yuko Oya
    • Tatsuya Yoshida
    • Takehiro Uemura
    • Yoshiko Murakami
    • Yoshitaka Inaba
    • Toyoaki Hida
  • View Affiliations

  • Published online on: July 17, 2018     https://doi.org/10.3892/ol.2018.9158
  • Pages: 4219-4222
  • Copyright: © Oya et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The resistance mechanisms to anaplastic lymphoma kinase (ALK) inhibitors comprise ALK gene variations, such as ALK point mutations and copy‑number gains, the activation of bypass signaling through the activation of other oncogenes and small cell lung cancer (SCLC) transformation. To date, few studies have investigated whether tumor markers for SCLC correlate with the SCLC transformation in EGFR‑mutant NSCLC and ALK‑positive non‑SCLC (NSCLC). The present case study reported a patient with SCLC transformation after alectinib treatment. The patient exhibited elevation of pro‑gastrin‑releasing peptide precursor and neuron‑specific enolase levels, which may be predictive of SCLC transformation during the resistance to ALK‑tyrosine kinase inhibitors.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Oya Y, Yoshida T, Uemura T, Murakami Y, Inaba Y and Hida T: Serum ProGRP and NSE levels predicting small cell lung cancer transformation in a patient with ALK rearrangement‑positive non‑small cell lung cancer: A case report. Oncol Lett 16: 4219-4222, 2018
APA
Oya, Y., Yoshida, T., Uemura, T., Murakami, Y., Inaba, Y., & Hida, T. (2018). Serum ProGRP and NSE levels predicting small cell lung cancer transformation in a patient with ALK rearrangement‑positive non‑small cell lung cancer: A case report. Oncology Letters, 16, 4219-4222. https://doi.org/10.3892/ol.2018.9158
MLA
Oya, Y., Yoshida, T., Uemura, T., Murakami, Y., Inaba, Y., Hida, T."Serum ProGRP and NSE levels predicting small cell lung cancer transformation in a patient with ALK rearrangement‑positive non‑small cell lung cancer: A case report". Oncology Letters 16.4 (2018): 4219-4222.
Chicago
Oya, Y., Yoshida, T., Uemura, T., Murakami, Y., Inaba, Y., Hida, T."Serum ProGRP and NSE levels predicting small cell lung cancer transformation in a patient with ALK rearrangement‑positive non‑small cell lung cancer: A case report". Oncology Letters 16, no. 4 (2018): 4219-4222. https://doi.org/10.3892/ol.2018.9158