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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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October-2018 Volume 16 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Case Report Open Access

Serum ProGRP and NSE levels predicting small cell lung cancer transformation in a patient with ALK rearrangement‑positive non‑small cell lung cancer: A case report

  • Authors:
    • Yuko Oya
    • Tatsuya Yoshida
    • Takehiro Uemura
    • Yoshiko Murakami
    • Yoshitaka Inaba
    • Toyoaki Hida
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Oncology, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑8681, Japan, Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑8681, Japan, Department of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑8681, Japan
    Copyright: © Oya et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4219-4222
    |
    Published online on: July 17, 2018
       https://doi.org/10.3892/ol.2018.9158
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Abstract

The resistance mechanisms to anaplastic lymphoma kinase (ALK) inhibitors comprise ALK gene variations, such as ALK point mutations and copy‑number gains, the activation of bypass signaling through the activation of other oncogenes and small cell lung cancer (SCLC) transformation. To date, few studies have investigated whether tumor markers for SCLC correlate with the SCLC transformation in EGFR‑mutant NSCLC and ALK‑positive non‑SCLC (NSCLC). The present case study reported a patient with SCLC transformation after alectinib treatment. The patient exhibited elevation of pro‑gastrin‑releasing peptide precursor and neuron‑specific enolase levels, which may be predictive of SCLC transformation during the resistance to ALK‑tyrosine kinase inhibitors.
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Copy and paste a formatted citation
Spandidos Publications style
Oya Y, Yoshida T, Uemura T, Murakami Y, Inaba Y and Hida T: Serum ProGRP and NSE levels predicting small cell lung cancer transformation in a patient with ALK rearrangement‑positive non‑small cell lung cancer: A case report. Oncol Lett 16: 4219-4222, 2018.
APA
Oya, Y., Yoshida, T., Uemura, T., Murakami, Y., Inaba, Y., & Hida, T. (2018). Serum ProGRP and NSE levels predicting small cell lung cancer transformation in a patient with ALK rearrangement‑positive non‑small cell lung cancer: A case report. Oncology Letters, 16, 4219-4222. https://doi.org/10.3892/ol.2018.9158
MLA
Oya, Y., Yoshida, T., Uemura, T., Murakami, Y., Inaba, Y., Hida, T."Serum ProGRP and NSE levels predicting small cell lung cancer transformation in a patient with ALK rearrangement‑positive non‑small cell lung cancer: A case report". Oncology Letters 16.4 (2018): 4219-4222.
Chicago
Oya, Y., Yoshida, T., Uemura, T., Murakami, Y., Inaba, Y., Hida, T."Serum ProGRP and NSE levels predicting small cell lung cancer transformation in a patient with ALK rearrangement‑positive non‑small cell lung cancer: A case report". Oncology Letters 16, no. 4 (2018): 4219-4222. https://doi.org/10.3892/ol.2018.9158
Copy and paste a formatted citation
x
Spandidos Publications style
Oya Y, Yoshida T, Uemura T, Murakami Y, Inaba Y and Hida T: Serum ProGRP and NSE levels predicting small cell lung cancer transformation in a patient with ALK rearrangement‑positive non‑small cell lung cancer: A case report. Oncol Lett 16: 4219-4222, 2018.
APA
Oya, Y., Yoshida, T., Uemura, T., Murakami, Y., Inaba, Y., & Hida, T. (2018). Serum ProGRP and NSE levels predicting small cell lung cancer transformation in a patient with ALK rearrangement‑positive non‑small cell lung cancer: A case report. Oncology Letters, 16, 4219-4222. https://doi.org/10.3892/ol.2018.9158
MLA
Oya, Y., Yoshida, T., Uemura, T., Murakami, Y., Inaba, Y., Hida, T."Serum ProGRP and NSE levels predicting small cell lung cancer transformation in a patient with ALK rearrangement‑positive non‑small cell lung cancer: A case report". Oncology Letters 16.4 (2018): 4219-4222.
Chicago
Oya, Y., Yoshida, T., Uemura, T., Murakami, Y., Inaba, Y., Hida, T."Serum ProGRP and NSE levels predicting small cell lung cancer transformation in a patient with ALK rearrangement‑positive non‑small cell lung cancer: A case report". Oncology Letters 16, no. 4 (2018): 4219-4222. https://doi.org/10.3892/ol.2018.9158
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