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Article

Determination of the prognostic value of preoperative CA15‑3 and CEA in predicting the prognosis of young patients with breast cancer

  • Authors:
    • Xuan Li
    • Danian Dai
    • Bo Chen
    • Hailin Tang
    • Xiaoming Xie
    • Weidong Wei
  • View Affiliations / Copyright

    Affiliations: Department of Breast Oncology, Sun Yat‑sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China
  • Pages: 4679-4688
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    Published online on: July 17, 2018
       https://doi.org/10.3892/ol.2018.9160
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Abstract

To the best of our knowledge, no previous study has investigated the association of carcinoembryonic antigen (CEA) and cancer antigen 15‑3 (CA15‑3) with the prognosis for young patients (≤40 years) with breast cancer. In the present study, preoperative CEA and CA15‑3 serum levels were evaluated in the prediction of the prognosis for young patients with breast cancer. In total, 699 patients were recruited, for which the CEA and CA15‑3 serum levels had been measured prior to surgery via a blood sample. The optimal cut‑off high and low values were determined using receiver operating characteristic curve analysis and Youden's index. The value of CEA and CA15‑3 in predicting overall survival (OS) and disease‑free survival (DFS) were measured using univariate and multivariate Cox's regression analyses. The cut‑off values were 3.38 ng/ml and 12.32 U/ml for CEA and CA15‑3, respectively. It was identified that CEA, but not CA15‑3, was a predictor for the prognosis of the young patients with breast cancer. Multivariate analysis confirmed that CEA, but not CA15‑3, was an independent prognostic marker for all young patients with breast cancer. In total, 623 young patients exhibited decreased levels of CEA; in these patients, CA15‑3 with a cut‑off value of 12.48 U/ml was an independent prognostic factor for OS and DFS. Preoperative serum CEA may thus serve as an independent predictor of poor prognosis for young patients with breast cancer. However, for low‑risk patients with decreased CEA levels, serum CA15‑3 may supplement the prediction of overall prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Li X, Dai D, Chen B, Tang H, Xie X and Wei W: Determination of the prognostic value of preoperative CA15‑3 and CEA in predicting the prognosis of young patients with breast cancer. Oncol Lett 16: 4679-4688, 2018.
APA
Li, X., Dai, D., Chen, B., Tang, H., Xie, X., & Wei, W. (2018). Determination of the prognostic value of preoperative CA15‑3 and CEA in predicting the prognosis of young patients with breast cancer. Oncology Letters, 16, 4679-4688. https://doi.org/10.3892/ol.2018.9160
MLA
Li, X., Dai, D., Chen, B., Tang, H., Xie, X., Wei, W."Determination of the prognostic value of preoperative CA15‑3 and CEA in predicting the prognosis of young patients with breast cancer". Oncology Letters 16.4 (2018): 4679-4688.
Chicago
Li, X., Dai, D., Chen, B., Tang, H., Xie, X., Wei, W."Determination of the prognostic value of preoperative CA15‑3 and CEA in predicting the prognosis of young patients with breast cancer". Oncology Letters 16, no. 4 (2018): 4679-4688. https://doi.org/10.3892/ol.2018.9160
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Dai D, Chen B, Tang H, Xie X and Wei W: Determination of the prognostic value of preoperative CA15‑3 and CEA in predicting the prognosis of young patients with breast cancer. Oncol Lett 16: 4679-4688, 2018.
APA
Li, X., Dai, D., Chen, B., Tang, H., Xie, X., & Wei, W. (2018). Determination of the prognostic value of preoperative CA15‑3 and CEA in predicting the prognosis of young patients with breast cancer. Oncology Letters, 16, 4679-4688. https://doi.org/10.3892/ol.2018.9160
MLA
Li, X., Dai, D., Chen, B., Tang, H., Xie, X., Wei, W."Determination of the prognostic value of preoperative CA15‑3 and CEA in predicting the prognosis of young patients with breast cancer". Oncology Letters 16.4 (2018): 4679-4688.
Chicago
Li, X., Dai, D., Chen, B., Tang, H., Xie, X., Wei, W."Determination of the prognostic value of preoperative CA15‑3 and CEA in predicting the prognosis of young patients with breast cancer". Oncology Letters 16, no. 4 (2018): 4679-4688. https://doi.org/10.3892/ol.2018.9160
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