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Article

Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy

  • Authors:
    • Nurten Bahtiyar
    • İlhan Onaran
    • Birsen Aydemir
    • Onur Baykara
    • Selmin Toplan
    • Fulya Yaman Agaoglu
    • Mehmet Can Akyolcu
  • View Affiliations / Copyright

    Affiliations: Department of Biophysics, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul 34098, Turkey, Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul 34098, Turkey, Department of Biophysics, Faculty of Medicine, Sakarya University, Sakarya 54050, Turkey, Department of Radiation Oncology, Institute of Oncology, Istanbul University, Istanbul 34098, Turkey
  • Pages: 4745-4753
    |
    Published online on: July 18, 2018
       https://doi.org/10.3892/ol.2018.9167
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Abstract

Radiotherapy (RT) may result in platelet activation and thrombosis development. To the best of our knowledge, the potential effect of volumetric‑modulated arc therapy (VMAT), a novel radiotherapy technique, on platelet function and microRNA (miRNA/miR) expression has not been previously investigated. The present study aimed to determine the effect of VMAT on the alterations in platelet function parameters and miRNA expression levels. A total of 25 patients with prostate cancer and 25 healthy subjects were included in the present study. Blood samples were collected from the patient group on the day prior to RT (pre‑RT), the day RT was completed (post‑RT day 0), and 40 days following the end of therapy (post‑RT day 40). Platelet count, mean platelet volume (MPV) value, platelet aggregation, plasma P‑selectin, thrombospondin‑1, platelet factor 4, plasma miR‑223 and miR‑126 expression levels were measured. A significant decrease in platelet count in the post‑RT day 0 group was measured in comparison with the pre‑RT and the post‑RT day 40 groups. Pre‑RT MPV values were higher than those of the post‑RT day 0 and the post‑RT day 40 groups. No significant differences were observed in the levels of platelet activation markers or miR‑223 and miR‑126 expression levels between the RT groups. Although RT may result in a reduction in platelet and MPV counts, the results of the present study indicate that platelet activation markers are not affected by VMAT. Therefore, it is possible that no platelet activation occurs during VMAT, owing to the conformal dose distributions, improved target volume coverage and the sparing of normal tissues from undesired radiation.
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1 

Sun X, Liu Z, Yang Z, Xiao L, Wang F, He Y, Su P, Wang J and Jing B: Association of microRNA-126 expression with clinicopathological features and the risk of biochemical recurrence in prostate cancer patients undergoing radical prostatectomy. Diagn Pathol. 8:2082013. View Article : Google Scholar : PubMed/NCBI

2 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

3 

He J, Hua J, Ding N, Xu S, Sun R, Zhou G, Xie X and Wang J: Modulation of microRNAs by ionizing radiation in human gastric cancer. Oncol Rep. 32:787–793. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Li M, Li GF, Hou XY, Gao H, Xu YG and Zhao T: A dosimetric comparison between conventional fractionated and hypofractionated image-guided radiation therapies for localized prostate cancer. Chin Med J (Engl). 129:1447–1454. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Hayden AJ, Catton C and Pickles T: Radiation therapy in prostate cancer: A risk-adapted strategy. Curr Oncol. 17 Suppl 2:S18–S24. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Mottet N, Bellmunt J, Bolla M, Briers E, Cumberbatch MG, De Santis M, Fossati N, Gross T, Henry AM, Joniau S, et al: EAU-ESTRO-SIOG guidelines on prostate cancer Part 1: Screening, diagnosis, and local treatment with curative intent. Eur Urol. 71:618–629. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Yang FE, Vaida F, Ignacio L, Houghton A, Nauityal J, Halpern H, Sutton H and Vijayakumar S: Analysis of weekly complete blood counts in patients receiving standard fractionated partial body radiation therapy. Int J Radiat Oncol Biol Phys. 33:6171995. View Article : Google Scholar : PubMed/NCBI

8 

Verheij M, Dewit LG, Boomgaard MN, Brinkman HJ and van Mourik JA: Ionizing radiation enhances platelet adhesion to the extracellular matrix of human endothelial cells by an increase in the release of von Willebrand factor. Radiat Res. 137:202–207. 1994. View Article : Google Scholar : PubMed/NCBI

9 

Hallahan DE, Chen AY, Teng M and Cmelak AJ: Drug-radiation interactions in tumor blood vessels. Oncology (Williston Park). 13 10 Suppl 5:S71–S77. 1999.

10 

Sørensen HT, Mellemkjaer L, Olsen JH and Baron JA: Prognosis of cancers associated with venous thromboembolism. N Engl J Med. 343:1846–1850. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Kroll MH, Hellums JD, McIntire LV, Schafer AI and Moake JL: Platelets and shear stress. Blood. 88:1525–1541. 1996.PubMed/NCBI

12 

Ni H and Freedman J: Platelets in hemostasis and thrombosis: Role of integrins and their ligands. Transfus Apher Sci. 28:257–264. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Arcangeli S and Greco C: Hypofractionated radiotherapy for organ-confined prostate cancer: Is less more? Nat Rev Urol. 13:400–408. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Zachariah B, Jacob SS, Gwede C, Cantor A, Patil J, Casey L and Zachariah AB: Effect of fractionated regional external beam radiotherapy on peripheral blood cell count. Int J Radiat Oncol Biol Phys. 50:465–472. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Lundgren MSFS, Cavalcanti MSM and Sampaio DA: Weekly monitoring of the effects of conventional external beam radiation therapy on patients with head and neck, chest, and pelvis cancer by means of blood cells count. Radiol Bras. 41:29–33. 2008. View Article : Google Scholar

16 

Ampil FL, Burton GV and Li BD: ‘Routine’ weekly blood counts during breast irradiation for early stage cancer: Are they really necessary? Breast J. 7:450–452. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Kalovidouris AE and Papayannis AG: Effect of ionizing radiation on platelet function in vitro. Acta Radiol Oncol. 20:333–336. 1981. View Article : Google Scholar : PubMed/NCBI

18 

Mihaescu A, Thornberg C, Santén S, Mattsson S, Jeppsson B and Thorlacius H: Radiation-induced platelet-endothelial cell interactions are mediated by P-selectin and P-selectin glycoprotein ligand-1 in the colonic microcirculation. Surgery. 151:606–611. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Zekanowska E, Rystok-Grabska D, Wisniewski T, Ziolkowska E, Slomka A, Giemza-Kucharska P and Rosc D: C0141 Radiotherapy and platelets activation in patients with prostate cancer. Thromb Res. 130:S163–S164. 2012. View Article : Google Scholar

20 

Lewinski A, Brona A, Lewandowski KC, Jedrzejuk D, Bohdanowicz-Pawlak A, Skowronska-Jozwiak E, Bienkiewicz M and Milewicz A: Effects of radioiodine administration on serum concentrations of matrix metalloproteinases, adiponectin and thrombospondin-1. Thyroid Res. 6:92013. View Article : Google Scholar : PubMed/NCBI

21 

Lambert MP, Xiao L, Nguyen Y, Kowalska MA and Poncz M: The role of platelet factor 4 in radiation-induced thrombocytopenia. Int J Radiat Oncol Biol Phys. 80:1533–1540. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Willeit P, Zampetaki A, Dudek K, Kaudewitz D, King A, Kirkby NS, Crosby-Nwaobi R, Prokopi M, Drozdov I, Langley SR, et al: Circulating microRNAs as novel biomarkers for trombosit activation. Circ Res. 112:595–600. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Nagalla S, Shaw C, Kong X, Kondkar AA, Edelstein LC, Ma L, Chen J, McKnight GS, López JA, Yang L, et al: Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity. Blood. 117:5189–5197. 2011. View Article : Google Scholar : PubMed/NCBI

24 

de Boer HC, van Solingen C, Prins J, Duijs JM, Huisman MV, Rabelink TJ and van Zonneveld AJ: Aspirin treatment hampers the use of plasma microRNA-126 as a biomarker for the progression of vascular disease. Eur Heart J. 34:3451–3457. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Tian HS, Zhou QG and Shao F: Relationship between arterial atheromatous plaque morphology and platelet-associated miR-126 and miR-223 expressions. Asian Pac J Trop Med. 8:309–314. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Yu XY, Chen JY, Zheng ZW, Wu H, Li LW, Zhang ZW, Chen ZH, Lin QX, Han YL and Zhong SL: Plasma miR-126 as a potential marker predicting major adverse cardiac events in dual antiplatelet-treated patients after percutaneous coronary intervention. EuroIntervention. 9:546–554. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Zhang YY, Zhou X, Ji WJ, Shi R, Lu RY, Li JL, Yang GH, Luo T, Zhang JQ, Zhao JH, et al: Decreased circulating microRNA-223 level predicts high on-treatment platelet reactivity in patients with troponin-negative non-ST elevation acute coronary syndrome. J Thromb Thrombolysis. 38:65–72. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Ramírez C, Cavallari U, Trabetti E, Sabaté M, Jimenez-Quevedo P, Hernández R, Moreno R, et al: Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease. Thromb Res. 116:491–497. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Ruggeri ZM: New insights into the mechanisms of platelet adhesion and aggregation. Semin Hematol. 31:229–239. 1994.PubMed/NCBI

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta DeltaC (T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Burdak-Rothkamm S and Prise KM: New molecular targets in radiotherapy: DNA damage signalling and repair in targeted and non-targeted cells. Eur J Pharmacol. 625:151–155. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Mouthon MA, Vereycken-Holler V, Van der Meeren A and Gaugler MH: Irradiation increases the interactions of platelets with the endothelium in vivo: Analysis by intravital microscopy. Radiat Res. 160:593–599. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Hallahan DE, Staba-Hogan MJ, Virudachalam S and Kolchinsky A: X-ray-induced P-selectin localization to the lumen of tumor blood vessels. Cancer Res. 58:5216–5220. 1998.PubMed/NCBI

34 

Hallahan DE and Virudachalam S: Accumulation of P-selectin in the lumen of irradiated blood vessels. Radiat Re. 152:6–13. 1999. View Article : Google Scholar

35 

Otto K: Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys. 35:310–317. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Cozzi L, Dinshaw KA, Shrivastava SK, Mahantshetty U, Engineer R, Deshpande DD, Jamema SV, Vanetti E, Clivio A, Nicolini G and Fogliata A: A treatment planning study comparing volumetric arc modulation with RapidArc and fixed field IMRT for cervix uteri radiotherapy. Radiother Oncol. 89:180–191. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Nabavizadeh N, Simeonova AO, Waller JG, Romer JL, Monaco DL, Elliott DA, Tanyi JA, Fuss M, Thomas CR Jr and Holland JM: Volumetric-modulated arc radiotherapy for pancreatic malignancies: Dosimetric comparison with sliding-window intensity-modulated radiotherapy and 3-dimensional conformal radiotherapy. Med Dosim. 39:256–260. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Blank KR, Cascardi MA and Kao GD: The utility of serial complete blood count monitoring in patients receiving radiation therapy for localized prostate cancer. Int J Radiat Oncol Biol Phys. 44:317–321. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Pinkawa M, Djukic V, Klotz J, Petz D, Piroth MD, Holy R and Eble MJ: Hematologic changes during prostate cancer radiation therapy are dependent on the treatment volume. Future Oncol. 10:835–843. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Kennedy AR, Maity A and Sanzari JK: A review of radiation-induced coagulopathy and new findings to support potential prevention strategies and treatments. Radiat Res. 186:121–140. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Mutlu H, Berk V, Karaca H, Erden A, Aslan T and Akca Z: Treatment regimen with bevacizumab decreases mean platelet volume in patients with metastatic colon cancer. Clin Appl Thromb Hemost. 18:546–548. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Khode V, Sindhur J, Kanbur K, Ruikar K and Nallulwar S: Mean platelet volume and other platelet volume indices in patients with stable coronary artery disease and acute myocardial infarction: A case control study. J Cardiovasc Dis Res. 3:272–275. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Riedl J, Kaider A, Reitter EM, Marosi C, Jäger U, Schwarzinger I, Zielinski C, Pabinger I and Ay C: Association of mean platelet volume with risk of venous thromboembolism and mortality in patients with cancer. Results from the vienna cancer and thrombosis study (CATS). Thromb Haemost. 111:670–678. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Inagaki N, Kibata K, Tamaki T, Shimizu T and Nomura S: Prognostic impact of the mean platelet volume/platelet count ratio in terms of survival in advanced non-small cell lung cancer. Lung Cancer. 83:97–101. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Cooke NM, Egan K, McFadden S, Grogan L, Breathnach OS, O'Leary J, Hennessy BT and Kenny D: Increased platelet reactivity in patients with late-stage metastatic cancer. Cancer Med. 2:564–570. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Johnson RC, Mayadas TN, Frenette PS, Mebius RE, Subramaniam M, Lacasce A, Hynes RO and Wagner DD: Blood cell dynamics in P-selectin-deficient mice. Blood. 86:1106–1114. 1995.PubMed/NCBI

47 

Esemuede N, Lee T, Pierre-Paul D, Sumpio BE and Gahtan V: The role of thrombospondin-1 in human disease. J Surg Res. 122:135–142. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Sachais BS, Higazi AA, Cines DB, Poncz M and Kowalska MA: Interactions of platelet factor 4 with the vessel wall. Semin Thromb Hemost. 30:351–358. 2004. View Article : Google Scholar : PubMed/NCBI

49 

Weiss K, Palumbo B, Palumbo I, Palumbo R, Granegger S, Hiltunen J and Sinzinger H: Platelet function after single [153Sm]EDTMP therapy in prostate cancer. Q J Nucl Med Mol Imaging. 50:330–333. 2006.PubMed/NCBI

50 

El Kaffas A, Smith K, Pradhan P, Machtaler S, Wang H, von Eyben R, Willmann JK and Hristov D: Molecular contrast-enhanced ultrasound imaging of radiation-induced P-Selectin expression in healthy mice colon. Int J Radiat Oncol Biol Phys. 97:581–585. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Rofstad EK, Henriksen K, Galappathi K and Mathiesen B: Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts. Cancer Res. 63:4055–4061. 2003.PubMed/NCBI

52 

Rofstad EK, Galappathi K and Mathiesen B: Thrombospondin-1 treatment prevents growth of dormant lung micrometastases after surgical resection and curative radiation therapy of the primary tumor in human melanoma xenografts. Int J Radiat Oncol Biol Phys. 58:493–499. 2004. View Article : Google Scholar : PubMed/NCBI

53 

Wiesner T, Bugl S, Mayer F, Hartmann JT and Kopp HG: Differential changes in platelet VEGF, Tsp, CXCL12, and CXCL4 in patients with metastatic cancer. Clin Exp Metastasis. 27:141–149. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Poruk KE, Firpo MA, Huerter LM, Scaife CL, Emerson LL, Boucher KM, Jones KA and Mulvihill SJ: Serum platelet factor 4 is an independent predictor of survival and venous thromboembolism in patients with pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 19:2605–2610. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Lam YW, Mobley JA, Evans JE, Carmody JF and Ho SM: Mass profiling-directed isolation and identification of a stage-specific serologic protein biomarker of advanced prostate cancer. Proteomics. 5:2927–2938. 2005. View Article : Google Scholar : PubMed/NCBI

56 

Chen JJ, Gao Y, Tian Q, Liang YM and Yang L: Platelet factor 4 protects bone marrow mesenchymal stem cells from acute radiation injury. Br J Radiol. 87:201401842014. View Article : Google Scholar : PubMed/NCBI

57 

Gatsiou A, Boeckel JN, Randriamboavonjy V and Stellos K: MicroRNAs in platelet biogenesis and function: Implications in vascular homeostasis and inflammation. Curr Vasc Pharmacol. 10:524–531. 2012. View Article : Google Scholar : PubMed/NCBI

58 

Edelstein LC, McKenzie SE, Shaw C, Holinstat MA, Kunapuli SP and Bray PF: MicroRNAs in platelet production and activation. J Thromb Haemost. 11 Suppl 1:S340–S350. 2013. View Article : Google Scholar

59 

Corsten MF, Dennert R, Jochems S, Kuznetsova T, Devaux Y, Hofstra L, Wagner DR, Staessen JA, Heymans S and Schroen B: Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease. Circ Cardiovasc Genet. 3:499–506. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Wang GK, Zhu JQ, Zhang JT, Li Q, Li Y, He J, Qin YW and Jing Q: Circulating microRNA: A novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J. 31:659–666. 2010. View Article : Google Scholar : PubMed/NCBI

61 

Li X, Zhang Y, Zhang H, Liu X, Gong T, Li M, Sun L, Ji G, Shi Y, Han Z, et al: miRNA-223 promotes gastric cancer invasion and metastasis by targeting tumor suppressor EPB41L3. Mol Cancer Res. 9:824–833. 2011. View Article : Google Scholar : PubMed/NCBI

62 

Garzon R, Pichiorri F, Palumbo T, Iuliano R, Cimmino A, Aqeilan R, Volinia S, Bhatt D, Alder H, Marcucci G, et al: MicroRNA fingerprints during human megakaryocytopoiesis. Proc Natl Acad Sci USA. 103:pp. 5078–5083. 2006; View Article : Google Scholar : PubMed/NCBI

63 

Templin T, Paul S, Amundson SA, Young EF, Barker CA, Wolden SL and Smilenov LB: Radiation-induced micro-RNA expression changes in peripheral blood cells of radiotherapy patients. Int J Radiat Oncol Biol Phys. 80:549–557. 2011. View Article : Google Scholar : PubMed/NCBI

64 

Cui W, Ma J, Wang Y and Biswal S: Plasma miRNA as biomarkers for assessment of total-body radiation exposure dosimetry. PLoS One. 6:e229882011. View Article : Google Scholar : PubMed/NCBI

65 

Jin L, Wang R, Jiang S, Yue J, Liu T, Dou X, Zhu K, Feng R, Xu X, Chen D and Yin Y: Dosimetric and clinical toxicity comparison of critical organ preservation with three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, and RapidArc for the treatment of locally advanced cancer of the pancreatic head. Curr Oncol. 23:e41–e48. 2016. View Article : Google Scholar : PubMed/NCBI

66 

Ponomaryova AA, Morozkin ES, Rykova EY, Zaporozhchenko IA, Skvortsova TE, Dobrodeev АY, Zavyalov AA, Tuzikov SA, Vlassov VV, Cherdyntseva NV, et al: Dynamic changes in circulating miRNA levels in response to antitumor therapy of lung cancer. Exp Lung Res. 42:95–102. 2016. View Article : Google Scholar : PubMed/NCBI

67 

Smirnov DA, Brady L, Halasa K, Morley M, Solomon S and Cheung VG: Genetic variation in radiation-induced cell death. Genome Res. 22:332–339. 2012. View Article : Google Scholar : PubMed/NCBI

68 

Foray N, Bourguignon M and Hamada N: Individual response to ionizing radiation. Mutat Res. 770:369–386. 2016. View Article : Google Scholar : PubMed/NCBI

69 

Mei N, Imada H, Nomoto S, Kunugita N and Norimura T: Individual variation and age dependency in the radiosensitivity of peripheral blood T-lymphocytes from normal donors. J Radiat Res. 37:235–245. 1996. View Article : Google Scholar : PubMed/NCBI

70 

Barber JB, West CM, Kiltie AE, Roberts SA and Scott D: Detection of individual differences in radiation-induced apoptosis of peripheral blood lymphocytes in normal individuals, ataxia telangiectasia homozygotes and heterozygotes, and breast cancer patients after radiotherapy. Radiat Res. 153:570–578. 2000. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Bahtiyar N, Onaran İ, Aydemir B, Baykara O, Toplan S, Agaoglu FY and Akyolcu MC: Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy. Oncol Lett 16: 4745-4753, 2018.
APA
Bahtiyar, N., Onaran, İ., Aydemir, B., Baykara, O., Toplan, S., Agaoglu, F.Y., & Akyolcu, M.C. (2018). Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy. Oncology Letters, 16, 4745-4753. https://doi.org/10.3892/ol.2018.9167
MLA
Bahtiyar, N., Onaran, İ., Aydemir, B., Baykara, O., Toplan, S., Agaoglu, F. Y., Akyolcu, M. C."Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy". Oncology Letters 16.4 (2018): 4745-4753.
Chicago
Bahtiyar, N., Onaran, İ., Aydemir, B., Baykara, O., Toplan, S., Agaoglu, F. Y., Akyolcu, M. C."Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy". Oncology Letters 16, no. 4 (2018): 4745-4753. https://doi.org/10.3892/ol.2018.9167
Copy and paste a formatted citation
x
Spandidos Publications style
Bahtiyar N, Onaran İ, Aydemir B, Baykara O, Toplan S, Agaoglu FY and Akyolcu MC: Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy. Oncol Lett 16: 4745-4753, 2018.
APA
Bahtiyar, N., Onaran, İ., Aydemir, B., Baykara, O., Toplan, S., Agaoglu, F.Y., & Akyolcu, M.C. (2018). Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy. Oncology Letters, 16, 4745-4753. https://doi.org/10.3892/ol.2018.9167
MLA
Bahtiyar, N., Onaran, İ., Aydemir, B., Baykara, O., Toplan, S., Agaoglu, F. Y., Akyolcu, M. C."Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy". Oncology Letters 16.4 (2018): 4745-4753.
Chicago
Bahtiyar, N., Onaran, İ., Aydemir, B., Baykara, O., Toplan, S., Agaoglu, F. Y., Akyolcu, M. C."Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy". Oncology Letters 16, no. 4 (2018): 4745-4753. https://doi.org/10.3892/ol.2018.9167
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