Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy

  • Authors:
    • Nurten Bahtiyar
    • İlhan Onaran
    • Birsen Aydemir
    • Onur Baykara
    • Selmin Toplan
    • Fulya Yaman Agaoglu
    • Mehmet Can Akyolcu
  • View Affiliations

  • Published online on: July 18, 2018     https://doi.org/10.3892/ol.2018.9167
  • Pages: 4745-4753
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Radiotherapy (RT) may result in platelet activation and thrombosis development. To the best of our knowledge, the potential effect of volumetric‑modulated arc therapy (VMAT), a novel radiotherapy technique, on platelet function and microRNA (miRNA/miR) expression has not been previously investigated. The present study aimed to determine the effect of VMAT on the alterations in platelet function parameters and miRNA expression levels. A total of 25 patients with prostate cancer and 25 healthy subjects were included in the present study. Blood samples were collected from the patient group on the day prior to RT (pre‑RT), the day RT was completed (post‑RT day 0), and 40 days following the end of therapy (post‑RT day 40). Platelet count, mean platelet volume (MPV) value, platelet aggregation, plasma P‑selectin, thrombospondin‑1, platelet factor 4, plasma miR‑223 and miR‑126 expression levels were measured. A significant decrease in platelet count in the post‑RT day 0 group was measured in comparison with the pre‑RT and the post‑RT day 40 groups. Pre‑RT MPV values were higher than those of the post‑RT day 0 and the post‑RT day 40 groups. No significant differences were observed in the levels of platelet activation markers or miR‑223 and miR‑126 expression levels between the RT groups. Although RT may result in a reduction in platelet and MPV counts, the results of the present study indicate that platelet activation markers are not affected by VMAT. Therefore, it is possible that no platelet activation occurs during VMAT, owing to the conformal dose distributions, improved target volume coverage and the sparing of normal tissues from undesired radiation.
View Figures
View References

Related Articles

Journal Cover

October-2018
Volume 16 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Bahtiyar N, Onaran İ, Aydemir B, Baykara O, Toplan S, Agaoglu FY and Akyolcu MC: Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy. Oncol Lett 16: 4745-4753, 2018
APA
Bahtiyar, N., Onaran, İ., Aydemir, B., Baykara, O., Toplan, S., Agaoglu, F.Y., & Akyolcu, M.C. (2018). Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy. Oncology Letters, 16, 4745-4753. https://doi.org/10.3892/ol.2018.9167
MLA
Bahtiyar, N., Onaran, İ., Aydemir, B., Baykara, O., Toplan, S., Agaoglu, F. Y., Akyolcu, M. C."Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy". Oncology Letters 16.4 (2018): 4745-4753.
Chicago
Bahtiyar, N., Onaran, İ., Aydemir, B., Baykara, O., Toplan, S., Agaoglu, F. Y., Akyolcu, M. C."Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy". Oncology Letters 16, no. 4 (2018): 4745-4753. https://doi.org/10.3892/ol.2018.9167