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Article Open Access

Study of miR-143 expression in stomach cancer

Retraction in: /10.3892/ol.2023.13743
  • Authors:
    • Shao-Jun Huang
    • Yu-Fang Zhu
    • Zeng Liu
    • Qing-Feng Li
    • Zhao-Yuan Li
    • Wen-Rong Fu
  • View Affiliations / Copyright

    Affiliations: Department of Medical Laboratory, Xiangyang Central Hospital, The Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei 441021, P.R. China, Department of Oncology, Xiangyang Central Hospital, The Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei 441021, P.R. China, Department of Pathology, Xiangyang Central Hospital, The Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei 441021, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4367-4371
    |
    Published online on: July 18, 2018
       https://doi.org/10.3892/ol.2018.9173
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Abstract

The present study was planned to investigate miR-143 expression during stomach cancer. The study explored the relationship between miR-143 expression and clinicopathological characteristics including proliferation, migration and apoptosis of stomach cancer cells. Sixty-three samples from each of stomach cancer tissue and surrounding tissue were obtained. Total RNA was extracted. The expression levels of miR-143 from stomach cancer tissue as well as from surrounding tissue were measured by semi-quantitative PCR. The effects of miR-143 overexpression on the migration of stomach cancer cells were examined by Transwell assay. The effects of miR-143 overexpression on the apoptosis of stomach cancer cells were examined by flow cytometer. The expression level of miR-143 was significantly decreased in stomach cancer tissues in comparison to surrounding tissues (P<0.01). Moreover, the expression of miR-143 related well with the tumor size, TNM stage, lymphatic metastasis and relapse (P<0.01). On the other hand, stomach cancer cell line with overexpression of miR-143, showed significant decline in proliferation rate and migration rate comparison to control cells (P<0.01). However, it showed significant higher in apoptosis rate (P<0.01). The present study concluded that expression of miR-143 is low during stomach cancer. Further, higher expression levels of miR-143 have the ability to decline proliferation and migration of stomach cancer cells. In this manner, the expression level of miR-143 could be used as an important factor to determine the severity of stomach cancer.
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View References

1 

Chen X-Z, Chen H, Castro FA, Hu JK and Brenner H: Epstein-Barr virus infection and gastric cancer: A systematic review. Medicine (Baltimore). 94:563–568. 2015.

2 

Lee JH, Kim JG, Jung HK, Kim JH, Jeong WK, Jeon TJ, Kim JM, Kim YI, Ryu KW, Kong SH, et al: Clinical practice guidelines for gastric cancer in Korea: An evidence-based approach. J Gastric Cancer. 14:87–104. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Son T, Kwon IG and Hyung WJ: Minimally invasive surgery for gastric cancer treatment: Current status and future perspectives. Gut Liver. 8:229–236. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Yoon H and Kim N: Diagnosis and management of high risk group for gastric cancer. Gut Liver. 9:5–17. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Miki K: Gastric cancer screening by combined assay for serum anti-Helicobacter pylori IgG antibody and serum pepsinogen levels - ‘ABC method’. Proc Jpn Acad Ser B Phys Biol Sci. 87:405–414. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Wu HH, Lin WC and Tsai KW: Advances in molecular biomarkers for gastric cancer: miRNAs as emerging novel cancer markers. Expert Rev Mol Med. 16:e12014. View Article : Google Scholar : PubMed/NCBI

7 

Zhang HB, Sun LC, Ling L, Cong LH and Lian R: miR-143 suppresses the proliferation of NSCLC cells by inhibiting the epidermal growth factor receptor. Exp Ther Med. 12:1795–1802. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Su J, Liang H, Yao W, Wang N, Zhang S, Yan X, Feng H, Pang W, Wang Y, Wang X, et al: MiR-143 and MiR-145 regulate IGF1R to suppress cell proliferation in colorectal cancer. PLoS One. 9:e1144202014. View Article : Google Scholar : PubMed/NCBI

9 

Adlakha YK and Saini N: Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128. Mol Cancer. 13:332014. View Article : Google Scholar : PubMed/NCBI

10 

Soares RJ, Cagnin S, Chemello F, Silvestrin M, Musaro A, De Pitta C, Lanfranchi G and Sandri M: Involvement of microRNAs in the regulation of muscle wasting during catabolic conditions. J Biol Chem. 289:21909–21925. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Lamontagne J, Steel LF and Bouchard MJ: Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases. World J Gastroenterol. 21:7375–7399. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Zhu Y, Jiang Q, Lou X, Ji X, Wen Z, Wu J, Tao H, Jiang T, He W, Wang C, et al: : MicroRNAs up-regulated by CagA of Helicobacter pylori induce intestinal metaplasia of gastric epithelial cells. PLoS One. 7:e351472012. View Article : Google Scholar : PubMed/NCBI

13 

Jianjun Z, Fan W, Yihua L, Juan X and Mei X: MicroRNA transcriptome profile analysis in porcine muscle and the effect of miR-143 on the MYH7 gene and protein. Biochim Biophys Acta. 10:215–237. 2015.

14 

Khafaei M, Samie S, Mowla SJ, Alvanegh AG, Mirzaei B, Chavoshei S, Dorraj GS, Esmailnejad M, Tavallaie M and Nourani M: Evaluation of miR-9 and miR-143 expression in urine specimens of sulfur mustard exposed patients. Interdiscip Toxicol. 8:169–174. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Tang S, Bonaroti J, Unlu S, Liang X, Tang D, Zeh HJ and Lotze MT: Sweating the small stuff: microRNAs and genetic changes define pancreatic cancer. Pancreas. 42:740–759. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Li A, Omura N, Hong SM, Vincent A, Walter K, Griffith M, Borges M and Goggins M: Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels. Cancer Res. 70:5226–5237. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Yan X, Chen X, Liang H, Deng T, Chen W, Zhang S, Liu M, Gao X, Liu Y, Zhao C, et al: miR-143 and miR-145 synergistically regulate ERBB3 to suppress cell proliferation and invasion in breast cancer. Mol Cancer. 13:2202014. View Article : Google Scholar : PubMed/NCBI

18 

Hongyan Z, Urszula D, Victoria R and Reba M: EGFR signals down-regulate tumor suppressors miR-143 and miR-145 in Western diet-promoted murine colon cancer: Role of G1 regulators. Mol Cancer Res. 9:176–184. 2011.

19 

Wu XL, Cheng B, Li PY, Huang HJ, Zhao Q, Dan ZL, Tian DA and Zhang P: MicroRNA-143 suppresses gastric cancer cell growth and induces apoptosis by targeting COX-2. World J Gastroenterol. 19:7758–7765. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang S, Zhu Y, Liu Z, Li Q, Li Z and Fu W: Study of miR-143 expression in stomach cancer Retraction in /10.3892/ol.2023.13743. Oncol Lett 16: 4367-4371, 2018.
APA
Huang, S., Zhu, Y., Liu, Z., Li, Q., Li, Z., & Fu, W. (2018). Study of miR-143 expression in stomach cancer Retraction in /10.3892/ol.2023.13743. Oncology Letters, 16, 4367-4371. https://doi.org/10.3892/ol.2018.9173
MLA
Huang, S., Zhu, Y., Liu, Z., Li, Q., Li, Z., Fu, W."Study of miR-143 expression in stomach cancer Retraction in /10.3892/ol.2023.13743". Oncology Letters 16.4 (2018): 4367-4371.
Chicago
Huang, S., Zhu, Y., Liu, Z., Li, Q., Li, Z., Fu, W."Study of miR-143 expression in stomach cancer Retraction in /10.3892/ol.2023.13743". Oncology Letters 16, no. 4 (2018): 4367-4371. https://doi.org/10.3892/ol.2018.9173
Copy and paste a formatted citation
x
Spandidos Publications style
Huang S, Zhu Y, Liu Z, Li Q, Li Z and Fu W: Study of miR-143 expression in stomach cancer Retraction in /10.3892/ol.2023.13743. Oncol Lett 16: 4367-4371, 2018.
APA
Huang, S., Zhu, Y., Liu, Z., Li, Q., Li, Z., & Fu, W. (2018). Study of miR-143 expression in stomach cancer Retraction in /10.3892/ol.2023.13743. Oncology Letters, 16, 4367-4371. https://doi.org/10.3892/ol.2018.9173
MLA
Huang, S., Zhu, Y., Liu, Z., Li, Q., Li, Z., Fu, W."Study of miR-143 expression in stomach cancer Retraction in /10.3892/ol.2023.13743". Oncology Letters 16.4 (2018): 4367-4371.
Chicago
Huang, S., Zhu, Y., Liu, Z., Li, Q., Li, Z., Fu, W."Study of miR-143 expression in stomach cancer Retraction in /10.3892/ol.2023.13743". Oncology Letters 16, no. 4 (2018): 4367-4371. https://doi.org/10.3892/ol.2018.9173
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