Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

A TOP2A‑derived cancer panel drives cancer progression in papillary renal cell carcinoma

  • Authors:
    • Mushi Ye
    • Zhuobin He
    • Wei Dai
    • Zhuo Li
    • Xiaojun Chen
    • Jianjun Liu
  • View Affiliations / Copyright

    Affiliations: Department of Urological Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China, Department of Urological Surgery, Da Lang Hospital of Dongguan, Dongguan, Guangdong 523770, P.R. China, Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China
    Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4169-4178
    |
    Published online on: July 19, 2018
       https://doi.org/10.3892/ol.2018.9179
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the function of the DNA topoisomerase IIα (TOP2A) gene and its associated genes in the progression of papillary renal cell carcinoma (PRCC). Online cancer databases, including cBioportal, Oncomine, OncoLnc and Search Tool for the Retrieval of Interacting Genes/Proteins were used to analyze the TOP2A gene expression profile, function and regulation network in PRCC. The genes that were significantly co‑expressed or mutually exclusively expressed with TOP2A were identified. The genes co‑expressed with TOP2A were defined as a ‘TOP2A‑cancer panel’, which cooperatively promotes PRCC progression. This gene panel performed well in predicting the prognosis of PRCC. In addition, the TOP2A‑cancer panel significantly affected the outcome of PRCC compared with clear cell renal cell carcinoma (CCRCC). The protein‑protein interaction network of all genes associated with TOP2A was also generated. This interaction network may provide foundation for the additional investigation of TOP2A. Integrative understating of the TOP2A‑cancer panel may result in a novel avenue for treatment intervention in PRCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Dalton E and Thompson J: AB054. Overview of multi-gene panels for hereditary cancer. Ann Transl Med. 3:AB0542015.

2 

Lincoln SE, Kobayashi Y, Anderson MJ, Yang S, Desmond AJ, Mills MA, Nilsen GB, Jacobs KB, Monzon FA, Kurian AW, et al: A systematic comparison of traditional and multigene panel testing for hereditary breast and ovarian cancer genes in more than 1000 patients. J Mol Diagn. 17:533–544. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Housman G, Byler S, Heerboth S, Lapinska K, Longacre M, Snyder N and Sarkar S: Drug resistance in cancer: An overview. Cancers (Basel). 6:1769–1792. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Guo XE, Ngo B, Modrek AS and Lee WH: Targeting tumor suppressor networks for cancer therapeutics. Curr Drug Targets. 15:2–16. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Zhang Q, Madden NE, Wong AST, Chow BKC and Lee LTO: The role of endocrine G protein-coupled receptors in ovarian cancer progression. Front Endocrinol (Lausanne). 8:662017.PubMed/NCBI

6 

Shuch B, Hahn AW and Agarwal N: Current treatment landscape of advanced papillary renal cancer. J Clin Oncol. 35:2981–2983. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Ross H, Martignoni G and Argani P: Renal cell carcinoma with clear cell and papillary features. Arch Pathol Lab Med. 136:391–399. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Friedman AA, Letai A, Fisher DE and Flaherty KT: Precision medicine for cancer with next-generation functional diagnostics. Nat Rev Cancer. 15:747–756. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Lodish H, Berk A, Zipursky SL, Matsudaira P, Baltimore D and Darnell J: The Role of topoisomerases in DNA replication. Molecular Cell Biology. 4th edition. W.H. Freeman; New York, NY: 2000

10 

Chen T, Sun Y, Ji P, Kopetz S and Zhang W: Topoisomerase IIα in chromosome instability and personalized cancer therapy. Oncogene. 34:4019–4031. 2015. View Article : Google Scholar : PubMed/NCBI

11 

de Resende MF, Vieira S, Chinen LT, Chiappelli F, da Fonseca FP, Guimarães GC, Soares FA, Neves I, Pagotty S, Pellionisz PA, et al: Prognostication of prostate cancer based on TOP2A protein and gene assessment: TOP2A in prostate cancer. J Transl Med. 11:362013. View Article : Google Scholar : PubMed/NCBI

12 

Fountzilas G, Valavanis C, Kotoula V, Eleftheraki AG, Kalogeras KT, Tzaida O, Batistatou A, Kronenwett R, Wirtz RM, Bobos M, et al: HER2 and TOP2A in high-risk early breast cancer patients treated with adjuvant epirubicin-based dose-dense sequential chemotherapy. J Transl Med. 10:102012. View Article : Google Scholar : PubMed/NCBI

13 

Ito F, Furukawa N and Nakai T: Evaluation of top2a as a predictive marker for endometrial cancer with taxane-containing adjuvant chemotherapy. Int J Gynecol Cancer. 26:325–330. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Erriquez J, Becco P, Olivero M, Ponzone R, Maggiorotto F, Ferrero A, Scalzo MS, Canuto EM, Sapino A, Verdun di Cantogno L, et al: TOP2A gene copy gain predicts response of epithelial ovarian cancers to pegylated liposomal doxorubicin: TOP2A as marker of response to PLD in ovarian cancer. Gynecol Oncol. 138:627–633. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Tarpgaard LS, Qvortrup C, Nygård SB, Nielsen SL, Andersen DR, Jensen NF, Stenvang J, Detlefsen S, Brünner N and Pfeiffer P: A phase II study of epirubicin in oxaliplatin-resistant patients with metastatic colorectal cancer and TOP2A gene amplification. BMC Cancer. 16:912016. View Article : Google Scholar : PubMed/NCBI

16 

Wang J, Xu B, Yuan P, Zhang P, Li Q, Ma F and Fan Y: TOP2A amplification in breast cancer is a predictive marker of anthracycline-based neoadjuvant chemotherapy efficacy. Breast Cancer Res Treat. 135:531–537. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Cheburkin IuV, Kniazeva TG, Peter S, Kniazev IuP, Karelin MI, Shkol'nik MI, Evtushenko VI, Hanson KP, Ullrich A and Kniazev PG: Molecular portrait of human kidney carcinomas: The gene expression profiling of protein-tyrosine kinases and tyrosine phosphatases which controlled regulatory signals in the cells. Mol Biol (Mosk). 36:480–490. 2002.(In Russian). View Article : Google Scholar : PubMed/NCBI

18 

Chen D, Maruschke M, Hakenberg O, Zimmermann W, Stief CG and Buchner A: TOP2A, HELLS, ATAD2 and TET3 are novel prognostic markers in renal cell carcinoma. Urology. 102:265 e1–265 e7. 2017. View Article : Google Scholar

19 

Grossman RL, Heath AP, Ferretti V, Varmus HE, Lowy DR, Kibbe WA and Staudt LM: Toward a shared vision for cancer genomic data. N Engl J Med. 375:1109–1112. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Jones J, Otu H, Spentzos D, Kolia S, Inan M, Beecken WD, Fellbaum C, Gu X, Joseph M, Pantuck AJ, et al: Gene signatures of progression and metastasis in renal cell cancer. Clin Cancer Res. 11:5730–5739. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Lenburg ME, Liou LS, Gerry NP, Frampton GM, Cohen HT and Christman MF: Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data. BMC Cancer. 3:312003. View Article : Google Scholar : PubMed/NCBI

23 

Dannull J, Su Z, Rizzieri D, Yang BK, Coleman D, Yancey D, Zhang A, Dahm P, Chao N, Gilboa E and Vieweg J: Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J Clin Invest. 115:3623–3633. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Anaya J: OncoLnc: Linking TCGA survival data to mRNAs, miRNAs, and lncRNAs. PeerJ Computer Science. 2:e672016. View Article : Google Scholar

25 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:p112013. View Article : Google Scholar

26 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cbio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

27 

LaDuca H, Stuenkel AJ, Dolinsky JS, Keiles S, Tandy S, Pesaran T, Chen E, Gau CL, Palmaer E, Shoaepour K, et al: Utilization of multigene panels in hereditary cancer predisposition testing: Analysis of more than 2,000 patients. Genet Med. 16:830–837. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Capitanio U and Montorsi F: Renal cancer. Lancet. 387:894–906. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Siebels M, Negrier S, Chevreau C, Solska E, Desai AA, et al: Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 356:125–134. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Ronnen EA, Kondagunta GV, Ishill N, Spodek L, Russo P, Reuter V, Bacik J and Motzer RJ: Treatment outcome for metastatic papillary renal cell carcinoma patients. Cancer. 107:2617–2621. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Wang J, Xu B, Yuan P, Zhang P, Li Q, Ma F and Fan Y: TOP2A amplification in breast cancer is a predictive marker of anthracycline-based neoadjuvant chemotherapy efficacy. Breast Cancer Res Treat. 135:531–537. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Parker AS, Eckel-Passow JE, Serie D, Hilton T, Parasramka M, Joseph RW, Wu KJ, Cheville JC and Leibovich BC: Higher expression of topoisomerase II alpha is an independent marker of increased risk of cancer-specific death in patients with clear cell renal cell carcinoma. Eur Urol. 66:929–935. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Barr FA, Silljé HH and Nigg EA: Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol. 5:429–440. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Kufer TA, Silljé HH, Körner R, Gruss OJ, Meraldi P and Nigg EA: Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol. 158:617–623. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Parvin JD, Kais Z, Arora M, Kotian S, Zha A, Ransburgh D, Bozdag D, Catalyurek U and Huang K: Identification of a breast cancer associated regulatory network. Proceedings of the 2009 Ohio Collaborative Conference on Bioinformatics. Bioinformatics Cleveland, OH: pp. 71–75. 2009, View Article : Google Scholar

36 

Taylor SS, Scott MI and Holland AJ: The spindle checkpoint: A quality control mechanism which ensures accurate chromosome segregation. Chromosome Res. 12:599–616. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Kolodner RD and Marsischky GT: Eukaryotic DNA mismatch repair. Curr Opin Genet Dev. 9:89–96. 1999. View Article : Google Scholar : PubMed/NCBI

38 

Rath O and Kozielski F: Kinesins and cancer. Nat Rev Cancer. 12:527–539. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Yu Y and Feng YM: The role of kinesin family proteins in tumorigenesis and progression: Potential biomarkers and molecular targets for cancer therapy. Cancer. 116:5150–5160. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Hong KU, Kim E, Bae CD and Park J: TMAP/CKAP2 is essential for proper chromosome segregation. Cell Cycle. 8:314–324. 2009. View Article : Google Scholar : PubMed/NCBI

41 

DeLuca JG, Dong Y, Hergert P, Strauss J, Hickey JM, Salmon ED and McEwen BF: Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites. Mol Biol Cell. 16:519–531. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ye M, He Z, Dai W, Li Z, Chen X and Liu J: A TOP2A‑derived cancer panel drives cancer progression in papillary renal cell carcinoma. Oncol Lett 16: 4169-4178, 2018.
APA
Ye, M., He, Z., Dai, W., Li, Z., Chen, X., & Liu, J. (2018). A TOP2A‑derived cancer panel drives cancer progression in papillary renal cell carcinoma. Oncology Letters, 16, 4169-4178. https://doi.org/10.3892/ol.2018.9179
MLA
Ye, M., He, Z., Dai, W., Li, Z., Chen, X., Liu, J."A TOP2A‑derived cancer panel drives cancer progression in papillary renal cell carcinoma". Oncology Letters 16.4 (2018): 4169-4178.
Chicago
Ye, M., He, Z., Dai, W., Li, Z., Chen, X., Liu, J."A TOP2A‑derived cancer panel drives cancer progression in papillary renal cell carcinoma". Oncology Letters 16, no. 4 (2018): 4169-4178. https://doi.org/10.3892/ol.2018.9179
Copy and paste a formatted citation
x
Spandidos Publications style
Ye M, He Z, Dai W, Li Z, Chen X and Liu J: A TOP2A‑derived cancer panel drives cancer progression in papillary renal cell carcinoma. Oncol Lett 16: 4169-4178, 2018.
APA
Ye, M., He, Z., Dai, W., Li, Z., Chen, X., & Liu, J. (2018). A TOP2A‑derived cancer panel drives cancer progression in papillary renal cell carcinoma. Oncology Letters, 16, 4169-4178. https://doi.org/10.3892/ol.2018.9179
MLA
Ye, M., He, Z., Dai, W., Li, Z., Chen, X., Liu, J."A TOP2A‑derived cancer panel drives cancer progression in papillary renal cell carcinoma". Oncology Letters 16.4 (2018): 4169-4178.
Chicago
Ye, M., He, Z., Dai, W., Li, Z., Chen, X., Liu, J."A TOP2A‑derived cancer panel drives cancer progression in papillary renal cell carcinoma". Oncology Letters 16, no. 4 (2018): 4169-4178. https://doi.org/10.3892/ol.2018.9179
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team