miR‑23b suppresses lung carcinoma cell proliferation through CCNG1 Corrigendum in /10.3892/ol.2018.9790

Han,Hongsheng; Zhang,Zhenxian; Yang,Xueqin; Yang,Wenfeng; Xue,Chengwei; Cao,Xiaoli

doi:10.3892/ol.2018.9181

miR‑23b suppresses lung carcinoma cell proliferation through CCNG1

Corrigendum in: /10.3892/ol.2018.9790

Authors:
- Hongsheng Han
- Zhenxian Zhang
- Xueqin Yang
- Wenfeng Yang
- Chengwei Xue
- Xiaoli Cao
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Affiliations: Department of Radiology, People's Hospital of Yan'an, Yan'an, Shaanxi 716000, P.R. China, Department of Radiology, The Affiliated Hospital of Yan'an University, Yan'an, Shaanxi 716000, P.R. China
Published online on: July 20, 2018 https://doi.org/10.3892/ol.2018.9181
Pages: 4317-4324

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Abstract

Lung carcinoma with high incidence rate could be divided into four subtypes, including small cell carcinoma, squamous cell carcinoma, adenocarcinoma and large cell carcinoma. miR‑23b has been reported to have a low expression and play major roles in abundant tumors, however there is little research in lung carcinoma and hence the purpose of this study was to explore the impact of miR‑23b in lung carcinoma. The RNA level of miR‑23b and cyclin G1 (CCNG1) was measured by reverse transcription quantitative PCR. Luciferase activity reporter assay was used to verify that CCNG1 is a target of miR‑23b. MTT and Transwell assays were utilized to test the functional studies of miR‑23b in lung cancer cells. In lung carcinoma and lung cancer cells miR‑23b expression is low compared with that in paracancerous tissues and normal lung cells. Low miR‑23b expression inhibited lung cancer cell proliferation measured by MTT assay. We applied luciferase reporter to determine whether CCNG1 is a target of miR‑23b and there was a negative correlation between them. Moreover, interference with CCNG1 reduced the cell proliferation ability, which partially reversed function of miR‑23b. miR‑23b inhibited cell proliferation of lung cancer by directly targeting CCNG1. It is suggested that miR‑23b/CCNG1 axis may present a new target for the treatment of lung cancer.

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