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Article

Circulating long non‑coding RNAs HULC and ZNFX1‑AS1 are potential biomarkers in patients with gastric cancer

  • Authors:
    • Hai‑Peng Xian
    • Zhong‑Ling Zhuo
    • Yu‑Jing Sun
    • Bin Liang
    • Xiao‑Tao Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Peking University People's Hospital, Beijing 100044, P.R. China, Department of Clinical Laboratory, Peking University International Hospital, Beijing 102206, P.R. China, Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, P.R. China
  • Pages: 4689-4698
    |
    Published online on: July 24, 2018
       https://doi.org/10.3892/ol.2018.9199
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Abstract

Long non‑coding RNAs (lncRNAs) have been demonstrated to be involved in different types of cancer, including gastric cancer. Although altered lncRNAs profiles have been observed in or around gastric cancer tissues, the diagnostic value of circulating lncRNAs in gastric cancer remains unclear. In the present study, a number of highly expressed lncRNAs, including uc001lsz, GACAT2, ABHD11‑AS1, GACAT3, SUMP1P3, CHET1, TUG1, SNHG12, GAS5, PVT1, LINC00152, HOTAIR, CCAT1, H19, HULC and ZNFX1‑AS1, were investigated as potential minimally invasive biomarkers for this tumor. Preliminary screening experiments revealed that ZNFX1‑AS1 and HULC were differentially expressed in the plasma of gastric cancer patients and healthy control subjects. The study further examined the relative expression of ZNFX1‑AS1 and HULC in the plasma of 50 matching preoperative and postoperative patients, 50 gastrointestinal stromal tumor (GIST) patients, 50 gastritis/peptic ulcer patients and 50 healthy control subjects through reverse transcription‑quantitative polymerase chain reaction. The correlation of lncRNA relative expression with the general characteristics and clinicopathological factors was analyzed. It was observed that the levels of ZNFX1‑AS1 and HULC in the plasma of preoperative patients were markedly higher compared with those in the plasma of GIST patients, gastritis/peptic ulcer patients and healthy control subjects, while no significant difference was detected among these three groups. Receiver operating characteristic curve analysis was also conducted to distinguish gastric cancer patients from healthy control subjects. The area under the curve was 0.85 and 0.65 for ZNFX1‑AS1 and HULC, respectively. In conclusion, the results indicated that the lncRNAs ZNFX1‑AS1 and HULC are promising in the clinical diagnosis of gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Xian HP, Zhuo ZL, Sun YJ, Liang B and Zhao XT: Circulating long non‑coding RNAs HULC and ZNFX1‑AS1 are potential biomarkers in patients with gastric cancer. Oncol Lett 16: 4689-4698, 2018.
APA
Xian, H., Zhuo, Z., Sun, Y., Liang, B., & Zhao, X. (2018). Circulating long non‑coding RNAs HULC and ZNFX1‑AS1 are potential biomarkers in patients with gastric cancer. Oncology Letters, 16, 4689-4698. https://doi.org/10.3892/ol.2018.9199
MLA
Xian, H., Zhuo, Z., Sun, Y., Liang, B., Zhao, X."Circulating long non‑coding RNAs HULC and ZNFX1‑AS1 are potential biomarkers in patients with gastric cancer". Oncology Letters 16.4 (2018): 4689-4698.
Chicago
Xian, H., Zhuo, Z., Sun, Y., Liang, B., Zhao, X."Circulating long non‑coding RNAs HULC and ZNFX1‑AS1 are potential biomarkers in patients with gastric cancer". Oncology Letters 16, no. 4 (2018): 4689-4698. https://doi.org/10.3892/ol.2018.9199
Copy and paste a formatted citation
x
Spandidos Publications style
Xian HP, Zhuo ZL, Sun YJ, Liang B and Zhao XT: Circulating long non‑coding RNAs HULC and ZNFX1‑AS1 are potential biomarkers in patients with gastric cancer. Oncol Lett 16: 4689-4698, 2018.
APA
Xian, H., Zhuo, Z., Sun, Y., Liang, B., & Zhao, X. (2018). Circulating long non‑coding RNAs HULC and ZNFX1‑AS1 are potential biomarkers in patients with gastric cancer. Oncology Letters, 16, 4689-4698. https://doi.org/10.3892/ol.2018.9199
MLA
Xian, H., Zhuo, Z., Sun, Y., Liang, B., Zhao, X."Circulating long non‑coding RNAs HULC and ZNFX1‑AS1 are potential biomarkers in patients with gastric cancer". Oncology Letters 16.4 (2018): 4689-4698.
Chicago
Xian, H., Zhuo, Z., Sun, Y., Liang, B., Zhao, X."Circulating long non‑coding RNAs HULC and ZNFX1‑AS1 are potential biomarkers in patients with gastric cancer". Oncology Letters 16, no. 4 (2018): 4689-4698. https://doi.org/10.3892/ol.2018.9199
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