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Eps15 homology domain 1 promotes the evolution of papillary thyroid cancer by regulating endocytotic recycling of epidermal growth factor receptor

  • Authors:
    • Yu Liu
    • Yanan Liang
    • Ming Li
    • Duanyang Liu
    • Jing Tang
    • Weiwei Yang
    • Dandan Tong
    • Xiaoming Jin
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China, Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Pages: 4263-4270
    |
    Published online on: July 24, 2018
       https://doi.org/10.3892/ol.2018.9200
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Abstract

Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy, and it is often observed to overexpress epidermal growth factor receptor (EGFR). Previous research has indicated that EH domain‑containing 1 (EHD1) is associated with EGFR‑mediated endocytotic recycling in multiple tumor types. The objective of the present study was to determine the protein expression levels and clinical significance of EHD1, EGFR, caveolin‑1 (CAV‑1) and RAB11 family interacting protein 3 (RAB11FIP3) in PTC. PTC specimens were analyzed for EHD1, EGFR, CAV‑1 and RAB11FIP3 expression via immunohistochemistry and western blotting. The associations between protein expression and clinicopathological features were assessed. EHD1, EGFR, CAV‑1 and RAB11FIP3 expression levels were increased in human PTC. Additionally, the expression level of EHD1 protein was significantly associated with tumor size, lymph node metastasis and EGFR expression (P<0.05). CAV‑1 was associated with tumor size and EGFR expression (P<0.05). EGFR was only associated with lymph node metastasis (P=0.027) and RAB11FIP3 was not associated with any clinicopathological characteristics. The correlations between EHD1 and EGFR (r=0.564, P<0.05), CAV‑1 (r=0.865, P<0.01) and RAB11FIP3 (r=0.504, P<0.05) were statistically significant. Overall, EHD1, CAV‑1 and RAB11FIP3, which are key proteins in endocytotic recycling, promote PTC tumorigenesis through the regulation of the transport of EGFR.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Liang Y, Li M, Liu D, Tang J, Yang W, Tong D and Jin X: Eps15 homology domain 1 promotes the evolution of papillary thyroid cancer by regulating endocytotic recycling of epidermal growth factor receptor. Oncol Lett 16: 4263-4270, 2018.
APA
Liu, Y., Liang, Y., Li, M., Liu, D., Tang, J., Yang, W. ... Jin, X. (2018). Eps15 homology domain 1 promotes the evolution of papillary thyroid cancer by regulating endocytotic recycling of epidermal growth factor receptor. Oncology Letters, 16, 4263-4270. https://doi.org/10.3892/ol.2018.9200
MLA
Liu, Y., Liang, Y., Li, M., Liu, D., Tang, J., Yang, W., Tong, D., Jin, X."Eps15 homology domain 1 promotes the evolution of papillary thyroid cancer by regulating endocytotic recycling of epidermal growth factor receptor". Oncology Letters 16.4 (2018): 4263-4270.
Chicago
Liu, Y., Liang, Y., Li, M., Liu, D., Tang, J., Yang, W., Tong, D., Jin, X."Eps15 homology domain 1 promotes the evolution of papillary thyroid cancer by regulating endocytotic recycling of epidermal growth factor receptor". Oncology Letters 16, no. 4 (2018): 4263-4270. https://doi.org/10.3892/ol.2018.9200
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Liang Y, Li M, Liu D, Tang J, Yang W, Tong D and Jin X: Eps15 homology domain 1 promotes the evolution of papillary thyroid cancer by regulating endocytotic recycling of epidermal growth factor receptor. Oncol Lett 16: 4263-4270, 2018.
APA
Liu, Y., Liang, Y., Li, M., Liu, D., Tang, J., Yang, W. ... Jin, X. (2018). Eps15 homology domain 1 promotes the evolution of papillary thyroid cancer by regulating endocytotic recycling of epidermal growth factor receptor. Oncology Letters, 16, 4263-4270. https://doi.org/10.3892/ol.2018.9200
MLA
Liu, Y., Liang, Y., Li, M., Liu, D., Tang, J., Yang, W., Tong, D., Jin, X."Eps15 homology domain 1 promotes the evolution of papillary thyroid cancer by regulating endocytotic recycling of epidermal growth factor receptor". Oncology Letters 16.4 (2018): 4263-4270.
Chicago
Liu, Y., Liang, Y., Li, M., Liu, D., Tang, J., Yang, W., Tong, D., Jin, X."Eps15 homology domain 1 promotes the evolution of papillary thyroid cancer by regulating endocytotic recycling of epidermal growth factor receptor". Oncology Letters 16, no. 4 (2018): 4263-4270. https://doi.org/10.3892/ol.2018.9200
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