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Article Open Access

Osthole attenuates angiogenesis in an orthotopic mouse model of hepatocellular carcinoma via the downregulation of nuclear factor‑κB and vascular endothelial growth factor

  • Authors:
    • Fei Yao
    • Lurong Zhang
    • Guorong Jiang
    • Min Liu
    • Guoqiang Liang
    • Qin Yuan
  • View Affiliations / Copyright

    Affiliations: Laboratory of Clinical Pharmacy of Chinese Herb, Suzhou Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu 215000, P.R. China
    Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4471-4479
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    Published online on: July 25, 2018
       https://doi.org/10.3892/ol.2018.9213
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Abstract

Osthole has been demonstrated to have antitumor activity. Previous studies by our group indicated that osthole effectively inhibited tumor growth in hepatocellular carcinoma (HCC) through the induction of apoptosis and enhancement of antitumor immune responses in mice. The importance of angiogenesis in the proliferation, invasion and metastasis of tumor cells in HCC is well established. The present study aimed to investigate the effects of osthole on angiogenesis in an orthotopic mouse model of HCC. Orthotopic HCC in mice was established, and osthole at 61, 122 and 244 mg/kg was administered intraperitoneally once daily to the tumor‑bearing mice for 14 consecutive days. Immunohistochemistry was performed to analyze the microvessel density (MVD) of tissues, and the level of vascular endothelial growth factor (VEGF) was measured by ELISA. The protein levels of nuclear factor‑κB (NF‑κB) p65 and IκB‑α were also detected by western blotting. MVD was positively correlated with tumor weight in the orthotopic mouse model of HCC. Osthole administration significantly decreased MVD in tumor and adjacent tissues, and inhibited tumor growth. Furthermore, osthole downregulated the expression of VEGF and NF‑κB p65, and upregulated IκB‑α expression in tumor and adjacent tissues. To the best of our knowledge, the results of the present study demonstrated for the first time that osthole inhibits angiogenesis in an orthotopic mouse model of HCC, which may be one of the mechanisms underlying the anti‑HCC activity of osthole, which in turn may be mediated by the NF‑κB/VEGF signaling pathway. Therefore, osthole, a potential angiogenesis inhibitor and immune system enhancer, may be a promising lead compound for the treatment of HCC.
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1 

Detmar M: Tumor angiogenesis. J Investig Dermatol Symp Proc. 5:20–23. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Yance DR Jr and Sagap SM: Targeting angiogenesis with integrative cancer therapies. Integr Cancer Ther. 5:9–29. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Zhao Y and Adjei AA: Targeting angiogenesis in cancer therapy: Moving beyond vascular endothelial growth factor. Oncologist. 20:660–673. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Yu HB, Zhang HF, Zhang X, Li DY, Xue HZ, Pan CE and Zhao SH: Resveratrol inhibits VEGF expression of human hepatocellular carcinoma cells through a NF-kappa B-mediated mechanism. Hepatogastroenterology. 57:1241–1246. 2010.PubMed/NCBI

5 

Rajabi M and Mousa SA: The role of angiogenesis in cancer treatment. Biomedicines. 5:E342017. View Article : Google Scholar : PubMed/NCBI

6 

Berqers G and Hanahan D: Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer. 8:592–603. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Li C, Liu T, Bazhin AV and Yang Y: The sabotaging role of myeloid cells in anti-angiogenic therapy: Coordination of angiogenesis and immune suppression by hypoxia. J Cell Physiol. 232:2312–2322. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Hillen F and Griffioen AW: Tumour vascularization sprouting angiogenesis and beyond. Cancer Metastasis Rev. 26:489–502. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Chouaib S, Messai Y, Couve S, Escudier B, Hasmim M and Noman MZ: Hypoxia promotes tumor growth in linking angiogenesis to immune escape. Front Immunol. 3:212012. View Article : Google Scholar : PubMed/NCBI

10 

McDonald PC, Chafe SC and Dedhar S: Overcoming hypoxia-mediated tumor progression: Combinatorial approaches targeting ph regulation, angiogenesis and immune dysfunction. Front Cell Dev Biol. 4:272016. View Article : Google Scholar : PubMed/NCBI

11 

Li Y and Martin RC II: Herbal medicine and hepatocellular carcinoma: Applications and challenges. Evid Based Complement Alternat Med. 2011:5412092011. View Article : Google Scholar : PubMed/NCBI

12 

Yang LL, Wang MC, Chen LG and Wang CC: Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines. Planta Med. 69:1091–1095. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Riviere C, Goossens L, Pommery N, Fourneau C, Delelis A and Henichart JP: Antiproliferative effects of isopentenylated coumarins isolated from phellolophium madagascariense baker. Nat Prod Res. 20:909–916. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Xu X, Zhang Y, Qu D, Jiang T and Li S: Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway. J ExpClin Cancer Res. 30:33–39. 2011. View Article : Google Scholar

15 

Chou SY, Hsu CS, Wang KT, Wang MC and Wang CC: Antitumor effects of osthole from Cnidium monnieri: An in vitro and in vivo study. Phytother Res. 21:226–230. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Zhang L, Jiang G, Yao F, He Y, Liang G, Zhang Y, Hu B, Wu Y, Li Y and Liu H: Growth inhibition and apoptosis induced by osthole, a natural coumarin, in hepatocellular carcinoma. PLoS One. 7:e378652012. View Article : Google Scholar : PubMed/NCBI

17 

Zhang L, Jiang G, Yao F, Liang G, Wang F, Xu H, Wu Y, Yu X and Liu H: Osthole promotes anti-tumor immune responses in tumor-bearing mice with hepatocellular carcinoma. Immunopharmacol Immunotoxicol. 37:301–307. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Potente M, Gerhardt H and Carmeliet P: Basic and therapeutic aspects of angiogenesis. Cell. 146:873–887. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Turlin B, Le Quilleuc D, Leroyer P, Brissot P, Deugnier Y and Loréal O: High vascular endothelial growth factor(VEGF) expression in chemically-induced hepatic microcancers in mice. J Hepatol. 37:620–624. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Tong Q, Zheng L, Lin L, Li B, Wang D, Huang C and Li D: VEGF is upregulated by hypoxia-induced mitogenic factor via the PI-3K/Akt-NF-kappaB signaling pathway. Respir Res. 7:372006. View Article : Google Scholar : PubMed/NCBI

21 

Zhang Q, Lu Y, Proulx ST, Guo R, Yao Z, Schwarz EM, Boyce BF and Xing L: Increased lymphangiogenesis in joints of mice with inflammatory arthritis. Arthritis Res Ther. 9:R1182007. View Article : Google Scholar : PubMed/NCBI

22 

Kwon OJ, Kim PH, Huyn S, Wu L, Kim M and Yun CO: A hypoxia- and {alpha}-fetoprotein-dependent oncolytic adenovirus exhibits specific killing of hepatocellular carcinomas. Clin Cancer Res. 16:6071–6082. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Wei D, Li Q, Wang XL, Wang Y, Xu J, Feng F, Nan G, Wang B, Li C, Guo T, et al: Oncolytic Newcastle disease virus expressing chimeric antibody enhanced anti-tumor efficacy in orthotopic hepatoma-bearing mice. J ExpClin Cancer Res. 34:1532015.

24 

McFadden DG, Vernon A, Santiago PM, Martinez-McFaline R, Bhutkar A, Crowley DM, McMahon M, Sadow PM and Jacks T: p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer. Proc Natl Acad Sci U S A. 111:E1600–E1609. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Meng J, Liu Y, Han J, Tan Q, Chen S, Qiao K, Zhou H, Sun T and Yang C: Hsp90β promoted endothelial cell-dependent tumor angiogenesis in hepatocellular carcinoma. Mol Cancer. 16:722017. View Article : Google Scholar : PubMed/NCBI

26 

Kim HY, Kim J, Thi Ha HT, Bang OS, Lee WS and Hong S: Evaluation of anti-tumorigenic activity of BP3B against colon cancer with patient-derived tumor xenograft model. BMC Complement Altern Med. 16:4732016. View Article : Google Scholar : PubMed/NCBI

27 

Chen H, Zhang J, Luo J, Lai F, Wang Z, Tong H, Lu D, Bu H, Zhang R and Lin S: Antiangiogenic effects of oxymatrine on pancreatic cancer by inhibition of the NF-κB-mediated VEGF signaling pathway. Oncol Rep. 30:589–595. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Hui L and Chen Y: Tumor microenvironment: Sanctuary of the devil. Cancer Lett. 368:7–13. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Ribatti D and Vacca A: The role of microenvironment in tumor angiogenesis. Genes Nutr. 3:29–34. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Leenders MW, Nijkamp MW and Rinkes Borel IH: Mouse models in liver cancer research: A review of current literature. World J Gastroenterol. 14:6915–6923. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Rao Q, You A, Guo Z, Zuo B, Gao X, Zhang T, Du Z, Wu C and Yin H: Intrahepatic tissue implantation represents a favorable approach for establishing orthotopic transplantation hepatocellular carcinoma mouse models. PLoS One. 11:e01482632016. View Article : Google Scholar : PubMed/NCBI

32 

Li B, Zhang Y, Wu W, Du G, Cai L, Shi H and Chen S: Neovascularization of hepatocellular carcinoma in a nude mouse orthotopic liver cancer model: A morphological study using X-ray in-line phase-contrast imaging. BMC Cancer. 17:732017. View Article : Google Scholar : PubMed/NCBI

33 

Woodfield SE, Shi Y, Patel RH, Jin J, Major A, Sarabia SF, Starosolski Z, Zorman B, Gupta SS, Chen Z, et al: A novel cell line based orthotopic xenograft mouse model that recapitulates human hepatoblastoma. Sci Rep. 7:177512017. View Article : Google Scholar : PubMed/NCBI

34 

Weidner N, Semple JP, Welch WR and Folkman J: Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N Engl J Med. 324:1–8. 1991. View Article : Google Scholar : PubMed/NCBI

35 

El-Assal ON, Yamanoi A, Soda Y, Yamaguchi M, Igarashi M, Yamamoto A, Nabika T and Nagasue N: Clinical significance of microvessel density and vascular endothelial growth factor expression in hepatocellular carcinoma and surrounding liver: Possible involvement of vascular endothelial growth factor in the angiogenesis of cirrhotic liver. Hepatology. 27:1554–1562. 1998. View Article : Google Scholar : PubMed/NCBI

36 

Dai L, Peng XX, Tan EM and Zhang JY: Tumor-associated antigen CAPERα and microvessel density in hepatocellular carcinoma. Oncotarget. 7:16985–16995. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Cao Y and Langer R: A review of Judah Folkman's remarkable achievements in biomedicine. Proc Natl Acad Sci USA. 105:13203–13205. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Aggarwal BB, Vijayalekshmi RV and Sung B: Targeting inflammatory pathways for prevention and therapy of cancer: Short-term friend, long-term foe. Clin Cancer Res. 15:425–430. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Schmidt D, Textor B, Pein OT, Licht AH, Andrecht S, Sator-Schmitt M, Fusenig NE, Angel P and Schorpp-Kistner M: Critical role for NF-kappaB-induced JunB in VEGF regulation and tumor angiogenesis. EMBO J. 26:710–719. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Ismail HA, Lessard L, Mes-Masson AM and Saad F: Expression of NF-kappaB in prostate cancer lymph node metastases. Prostate. 58:308–313. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Ghosh S and Karin M: Missing pieces in the NF-kappaB puzzle. Cell. 109 Suppl:S81–S96. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Javan H, Szucsik AM, Li L, Schaaf CL, Salama ME and Selzman CH: Cardiomyocyte p65 nuclear factor-κB is necessary for compensatory adaptation to pressure overload. Circ Heart Fail. 8:109–118. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Zhang B, Wang D, Ji TF, Shi L and Yu JL: Overexpression of lncRNA ANRIL up-regulates VEGF expression and promotes angiogenesis of diabetes mellitus combined with cerebral infarction by activating NF-κB signaling pathway in a rat model. Oncotarget. 8:17347–17359. 2017.PubMed/NCBI

44 

Xiong HQ, Abbruzzese JL, Lin E, Wang L, Zheng L and Xie K: NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells. Int J Cancer. 108:181–188. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Yu C, Li P, Qi D, Wang L, Qu HL, Zhang YJ, Wang XK and Fan HY: Osthole protects sepsis-induced acute kidney injury via down-regulating NF-κB signal pathway. Oncotarget. 8:4796–4813. 2017.PubMed/NCBI

46 

Li YQ, Wang JY, Qian ZQ, Li YL, Li WN, Gao Y and Yang DL: Osthole inhibits intimal hyperplasia by regulating the NF-κB and TGF-β1/Smad2 signalling pathways in the rat carotid artery after balloon injury. Eur J Pharmacol. 811:232–239. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yao F, Zhang L, Jiang G, Liu M, Liang G and Yuan Q: Osthole attenuates angiogenesis in an orthotopic mouse model of hepatocellular carcinoma via the downregulation of nuclear factor‑κB and vascular endothelial growth factor. Oncol Lett 16: 4471-4479, 2018.
APA
Yao, F., Zhang, L., Jiang, G., Liu, M., Liang, G., & Yuan, Q. (2018). Osthole attenuates angiogenesis in an orthotopic mouse model of hepatocellular carcinoma via the downregulation of nuclear factor‑κB and vascular endothelial growth factor. Oncology Letters, 16, 4471-4479. https://doi.org/10.3892/ol.2018.9213
MLA
Yao, F., Zhang, L., Jiang, G., Liu, M., Liang, G., Yuan, Q."Osthole attenuates angiogenesis in an orthotopic mouse model of hepatocellular carcinoma via the downregulation of nuclear factor‑κB and vascular endothelial growth factor". Oncology Letters 16.4 (2018): 4471-4479.
Chicago
Yao, F., Zhang, L., Jiang, G., Liu, M., Liang, G., Yuan, Q."Osthole attenuates angiogenesis in an orthotopic mouse model of hepatocellular carcinoma via the downregulation of nuclear factor‑κB and vascular endothelial growth factor". Oncology Letters 16, no. 4 (2018): 4471-4479. https://doi.org/10.3892/ol.2018.9213
Copy and paste a formatted citation
x
Spandidos Publications style
Yao F, Zhang L, Jiang G, Liu M, Liang G and Yuan Q: Osthole attenuates angiogenesis in an orthotopic mouse model of hepatocellular carcinoma via the downregulation of nuclear factor‑κB and vascular endothelial growth factor. Oncol Lett 16: 4471-4479, 2018.
APA
Yao, F., Zhang, L., Jiang, G., Liu, M., Liang, G., & Yuan, Q. (2018). Osthole attenuates angiogenesis in an orthotopic mouse model of hepatocellular carcinoma via the downregulation of nuclear factor‑κB and vascular endothelial growth factor. Oncology Letters, 16, 4471-4479. https://doi.org/10.3892/ol.2018.9213
MLA
Yao, F., Zhang, L., Jiang, G., Liu, M., Liang, G., Yuan, Q."Osthole attenuates angiogenesis in an orthotopic mouse model of hepatocellular carcinoma via the downregulation of nuclear factor‑κB and vascular endothelial growth factor". Oncology Letters 16.4 (2018): 4471-4479.
Chicago
Yao, F., Zhang, L., Jiang, G., Liu, M., Liang, G., Yuan, Q."Osthole attenuates angiogenesis in an orthotopic mouse model of hepatocellular carcinoma via the downregulation of nuclear factor‑κB and vascular endothelial growth factor". Oncology Letters 16, no. 4 (2018): 4471-4479. https://doi.org/10.3892/ol.2018.9213
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