Open Access

The role of interleukin‑6‑STAT3 signalling in glioblastoma (Review)

  • Authors:
    • Alice J. West
    • Vanessa Tsui
    • Stanley S. Stylli
    • Hong P.T. Nguyen
    • Andrew P. Morokoff
    • Andrew H. Kaye
    • Rodney B. Luwor
  • View Affiliations

  • Published online on: July 27, 2018     https://doi.org/10.3892/ol.2018.9227
  • Pages: 4095-4104
  • Copyright: © West et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioblastoma is the most common type of malignant brain tumor among adults and is currently a non‑curable disease due primarily to its highly invasive phenotype, and the lack of successful current therapies. Despite surgical resection and post‑surgical treatment patients ultimately develop recurrence of the tumour. Several signalling molecules have been implicated in the development, progression and aggressiveness of glioblastoma. The present study reviewed the role of interleukin (IL)‑6, a cytokine known to be important in activating several pro‑oncogenic signaling pathways in glioblastoma. The current study particularly focused on the contribution of IL‑6 in recurrent glioblastoma, with particular focus on glioblastoma stem cells and resistance to therapy.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
West AJ, Tsui V, Stylli SS, Nguyen HP, Morokoff AP, Kaye AH and Luwor RB: The role of interleukin‑6‑STAT3 signalling in glioblastoma (Review). Oncol Lett 16: 4095-4104, 2018
APA
West, A.J., Tsui, V., Stylli, S.S., Nguyen, H.P., Morokoff, A.P., Kaye, A.H., & Luwor, R.B. (2018). The role of interleukin‑6‑STAT3 signalling in glioblastoma (Review). Oncology Letters, 16, 4095-4104. https://doi.org/10.3892/ol.2018.9227
MLA
West, A. J., Tsui, V., Stylli, S. S., Nguyen, H. P., Morokoff, A. P., Kaye, A. H., Luwor, R. B."The role of interleukin‑6‑STAT3 signalling in glioblastoma (Review)". Oncology Letters 16.4 (2018): 4095-4104.
Chicago
West, A. J., Tsui, V., Stylli, S. S., Nguyen, H. P., Morokoff, A. P., Kaye, A. H., Luwor, R. B."The role of interleukin‑6‑STAT3 signalling in glioblastoma (Review)". Oncology Letters 16, no. 4 (2018): 4095-4104. https://doi.org/10.3892/ol.2018.9227