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Article Open Access

Integrated bioinformatic analysis of microarray data reveals shared gene signature between MDS and AML

  • Authors:
    • Zhen Zhang
    • Lin Zhao
    • Xijin Wei
    • Qiang Guo
    • Xiaoxiao Zhu
    • Ran Wei
    • Xunqiang Yin
    • Yunhong Zhang
    • Bin Wang
    • Xia Li
  • View Affiliations / Copyright

    Affiliations: Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, P.R. China, Department of Peripheral Vascular Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250011, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Pages: 5147-5159
    |
    Published online on: July 31, 2018
       https://doi.org/10.3892/ol.2018.9237
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Abstract

Myeloid disorders, especially myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), cause significant mobility and high mortality worldwide. Despite numerous attempts, the common molecular events underlying the development of MDS and AML remain to be established. In the present study, 18 microarray datasets were selected, and a meta‑analysis was conducted to identify shared gene signatures and biological processes between MDS and AML. Using NetworkAnalyst, 191 upregulated and 139 downregulated genes were identified in MDS and AML, among which, PTH2R, TEC, and GPX1 were the most upregulated genes, while MME, RAG1, and CD79B were mostly downregulated. Comprehensive functional enrichment analyses revealed oncogenic signaling related pathway, fibroblast growth factor receptor (FGFR) and immune response related events, ‘interleukine‑6/interferon signaling pathway, and B cell receptor signaling pathway’, were the most upregulated and downregulated biological processes, respectively. Network based meta‑analysis ascertained that HSP90AA1 and CUL1 were the most important hub genes. Interestingly, our study has largely clarified the link between MDS and AML in terms of potential pathways, and genetic markers, which shed light on the molecular mechanisms underlying the development and transition of MDS and AML, and facilitate the understanding of novel diagnostic, therapeutic and prognostic biomarkers.
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1 

Morrison SJ and Scadden DT: The bone marrow niche for haematopoietic stem cells. Nature. 505:327–334. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Tenen DG, Hromas R, Licht JD and Zhang DE: Transcription factors, normal myeloid development, and leukemia. Blood. 90:489–519. 1997.PubMed/NCBI

3 

Ozbalak M, Cetiner M, Bekoz H, Atesoglu EB, Ar C, Salihoglu A, Tuzuner N and Ferhanoglu B: Azacitidine has limited activity in ‘real life’ patients with MDS and AML: A single centre experience. Hematol Oncol. 30:76–81. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Greenberg PL, Young NS and Gattermann N: Myelodysplastic syndromes. Hematology Am Soc Hematol Educ Program. 136–161. 2002.PubMed/NCBI

5 

Hope KJ, Jin L and Dick JE: Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol. 5:738–743. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Vardiman JW, Harris NL and Brunning RD: The World Health Organization (WHO) classification of the myeloid neoplasms. Blood. 100:2292–2302. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Adès L, Itzykson R and Fenaux P: Myelodysplastic syndromes. Lancet. 383:2239–2252. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Del Rey M, O'hagan K, Dellett M, Aibar S, Colyer HA, Alonso ME, Díez-Campelo M, Armstrong RN, Sharpe DJ, Gutiérrez NC, et al: Genome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes. Leukemia. 27:610–618. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Gomez-Cabrero D, Abugessaisa I, Maier D, Teschendorff A, Merkenschlager M, Gisel A, Ballestar E, Bongcam-Rudloff E, Conesa A and Tegnér J: Data integration in the era of omics: Current and future challenges. BMC Syst Biol. 8 Suppl 2:I12014. View Article : Google Scholar : PubMed/NCBI

10 

Xia J, Gill EE and Hancock RE: NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data. Nat Protoc. 10:823–844. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Haidich AB: Meta-analysis in medical research. Hippokratia. 14 Suppl 1:S29–S37. 2010.

12 

Johnson WE, Li C and Rabinovic A: Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics. 8:118–127. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Pellagatti A, Cazzola M, Giagounidis A, Perry J, Malcovati L, Della Porta MG, Jädersten M, Killick S, Verma A, Norbury CJ, et al: Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells. Leukemia. 24:756–764. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Sternberg A, Killick S, Littlewood T, Hatton C, Peniket A, Seidl T, Soneji S, Leach J, Bowen D, Chapman C, et al: Evidence for reduced B-cell progenitors in early (low-risk) myelodysplastic syndrome. Blood. 106:2982–2991. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Graubert TA, Shen D, Ding L, Okeyo-Owuor T, Lunn CL, Shao J, Krysiak K, Harris CC, Koboldt DC, Larson DE, et al: Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat Genet. 44:53–57. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Pellagatti A, Cazzola M, Giagounidis AA, Malcovati L, Porta MG, Killick S, Campbell LJ, Wang L, Langford CF, Fidler C, et al: Gene expression profiles of CD34+ cells in myelodysplastic syndromes: involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype. Blood. 108:337–345. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Gerstung M, Pellagatti A, Malcovati L, Giagounidis A, Porta MG, Jadersten M, Dolatshad H, Verma A, Cross NC, Vyas P, et al: Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes. Nat Commun. 6:59012015. View Article : Google Scholar : PubMed/NCBI

18 

Kikushige Y, Shima T, Takayanagi S, Urata S, Miyamoto T, Iwasaki H, Takenaka K, Teshima T, Tanaka T, Inagaki Y and Akashi K: TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells. Cell Stem Cell. 7:708–717. 2010. View Article : Google Scholar : PubMed/NCBI

19 

de Jonge HJ, Woolthuis CM, Vos AZ, Mulder A, van den Berg E, Kluin PM, van der Weide K, de Bont ES, Huls G, Vellenga E and Schuringa JJ: Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML. Leukemia. 25:1825–1833. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Bacher U, Schnittger S, Macijewski K, Grossmann V, Kohlmann A, Alpermann T, Kowarsch A, Nadarajah N, Kern W, Haferlach C and Haferlach T: Multilineage dysplasia does not influence prognosis in CEBPA-mutated AML, supporting the WHO proposal to classify these patients as a unique entity. Blood. 119:4719–4722. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Schneider V, Zhang L, Rojewski M, Fekete N, Schrezenmeier H, Erle A, Bullinger L, Hofmann S, Götz M, Döhner K, et al: Leukemic progenitor cells are susceptible to targeting by stimulated cytotoxic T cells against immunogenic leukemia-associated antigens. Int J Cancer. 137:2083–2092. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Virtaneva K, Wright FA, Tanner SM, Yuan B, Lemon WJ, Caligiuri MA, Bloomfield CD, De La Chapelle A and Krahe R: Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics. Proc Natl Acad Sci USA. 98:1124–1129. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Von Der Heide EK, Neumann M, Vosberg S, James AR, Schroeder MP, Ortiz-Tanchez J, Isaakidis K, Schlee C, Luther M, Jöhrens K, et al: Molecular alterations in bone marrow mesenchymal stromal cells derived from acute myeloid leukemia patients. Leukemia. 31:1069–1078. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Stirewalt DL, Meshinchi S, Kopecky KJ, Fan W, Pogosova-Agadjanyan EL, Engel JH, Cronk MR, Dorcy KS, McQuary AR, Hockenbery D, et al: Identification of genes with abnormal expression changes in acute myeloid leukemia. Genes Chromosomes Cancer. 47:8–20. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Stegmaier K, Ross KN, Colavito SA, O'malley S, Stockwell BR and Golub TR: Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation. Nat Genet. 36:257–263. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Vidal M, Cusick ME and Barabási AL: Interactome networks and human disease. Cell. 144:986–998. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Schramm SJ, Li SS, Jayaswal V, Fung DC, Campain AE, Pang CN, Scolyer RA, Yang YH, Mann GJ and Wilkins MR: Disturbed protein-protein interaction networks in metastatic melanoma are associated with worse prognosis and increased functional mutation burden. Pigment Cell Melanoma Res. 26:708–722. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Zhang L, Zhang X and Fan S: Meta-analysis of salt-related gene expression profiles identifies common signatures of salt stress responses in Arabidopsis. Plant Syst Evol. 303:757–774. 2017. View Article : Google Scholar

29 

Greenberg P, Cox C, Lebeau MM, Fenaux P, Morel P, Sanz G, Sanz M, Vallespi T, Hamblin T, Oscier D, et al: International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood. 89:2079–2088. 1997.PubMed/NCBI

30 

Bonardi F, Fusetti F, Deelen P, Van Gosliga D, Vellenga E and Schuringa JJ: A proteomics and transcriptomics approach to identify leukemic stem cell (LSC) markers. Mol Cell Proteomics. 12:626–637. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y and Hirai H: Molecular cloning and analysis of the human Tec protein-tyrosine kinase. Leukemia. 8:1663–1672. 1994.PubMed/NCBI

32 

Goncalves AC, Alves R, Baldeiras I, Cortesão E, Carda JP, Branco CC, Oliveiros B, Loureiro L, Pereira A, Costa Nascimento JM, et al: Genetic variants involved in oxidative stress, base excision repair, DNA methylation, and folate metabolism pathways influence myeloid neoplasias susceptibility and prognosis. Mol Carcinog. 56:130–148. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Pei S, Minhajuddin M, Callahan KP, Balys M, Ashton JM, Neering SJ, Lagadinou ED, Corbett C, Ye H, Liesveld JL, et al: Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells. J Biol Chem. 288:33542–33558. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Miraki-Moud F, Ghazaly E, Ariza-Mcnaughton L, Hodby KA, Clear A, Anjos-Afonso F, Liapis K, Grantham M, Sohrabi F, Cavenagh J, et al: Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo. Blood. 125:4060–4068. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Li G, Song Y, Zhang Y, Wang H and Xie J: miR-34b targets HSF1 to suppress cell survival in acute myeloid leukemia. Oncol Res. 24:109–116. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Miwa H, Beran M and Saunders GF: Expression of the Wilms' tumor gene (WT1) in human leukemias. Leukemia. 6:405–409. 1992.PubMed/NCBI

37 

Feldhahn N, Arutyunyan A, Stoddart S, Zhang B, Schmidhuber S, Yi SJ, Kim YM, Groffen J and Heisterkamp N: Environment-mediated drug resistance in Bcr/Abl-positive acute lymphoblastic leukemia. Oncoimmunology. 1:618–629. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Boultwood J, Pellagatti A, Watkins F, Campbell LJ, Esoof N, Cross NC, Eagleton H, Littlewood TJ, Fidler C and Wainscoat JS: Low expression of the putative tumour suppressor gene gravin in chronic myeloid leukaemia, myelodysplastic syndromes and acute myeloid leukaemia. Br J Haematol. 126:508–511. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Armengol G, Canellas A, Alvarez Y, Bastida P, Toledo JS, Mdel Pérez-Iribarne M, Camós M, Tuset E, Estella J, Coll MD, et al: Genetic changes including gene copy number alterations and their relation to prognosis in childhood acute myeloid leukemia. Leuk Lymphoma. 51:114–124. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Seedhouse CH, Mills KI, Ahluwalia S, Grundy M, Shang S, Burnett AK, Russell NH and Pallis M: Distinct poor prognostic subgroups of acute myeloid leukaemia, FLT3-ITD and P-glycoprotein-positive, have contrasting levels of FOXO1. Leuk Res. 38:131–137. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Gasparetto M, Pei S, Minhajuddin M, Khan N, Pollyea DA, Myers JR, Ashton JM, Becker MW, Vasiliou V, Humphries KR, et al: Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1. Haematologica. 102:1054–1065. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Barabási AL, Gulbahce N and Loscalzo J: Network medicine: A network-based approach to human disease. Nat Rev Genet. 12:56–68. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Taipale M, Jarosz DF and Lindquist S: HSP90 at the hub of protein homeostasis: Emerging mechanistic insights. Nat Rev Mol Cell Biol. 11:515–528. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Flandrin-Gresta P, Solly F, Aanei CM, Cornillon J, Tavernier E, Nadal N, Morteux F, Guyotat D, Wattel E and Campos L: Heat Shock Protein 90 is overexpressed in high-risk myelodysplastic syndromes and associated with higher expression and activation of focal adhesion kinase. Oncotarget. 3:1158–1168. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Tian WL, He F, Fu X, Lin JT, Tang P, Huang YM, Guo R and Sun L: High expression of heat shock protein 90 alpha and its significance in human acute leukemia cells. Gene. 542:122–128. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Flandrin P, Guyotat D, Duval A, Cornillon J, Tavernier E, Nadal N and Campos L: Significance of heat-shock protein (HSP) 90 expression in acute myeloid leukemia cells. Cell Stress Chaperones. 13:357–364. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Lin S, Li J, Zhou W, Qian W, Wang B and Chen Z: BIIB021, an Hsp90 inhibitor, effectively kills a myelodysplastic syndrome cell line via the activation of caspases and inhibition of PI3K/Akt and NF-κB pathway proteins. Exp Ther Med. 7:1539–1544. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Lazenby M, Hills R, Burnett AK and Zabkiewicz J: The HSP90 inhibitor ganetespib: A potential effective agent for Acute Myeloid Leukemia in combination with cytarabine. Leuk Res. 39:617–624. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, et al: Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature. 416:703–709. 2002. View Article : Google Scholar : PubMed/NCBI

50 

Nakayama KI and Nakayama K: Ubiquitin ligases: Cell-cycle control and cancer. Nat Rev Cancer. 6:369–381. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Ishino R, Minami K, Tanaka S, Nagai M, Matsui K, Hasegawa N, Roeder RG, Asano S and Ito M: FGF7 supports hematopoietic stem and progenitor cells and niche-dependent myeloblastoma cells via autocrine action on bone marrow stromal cells in vitro. Biochem Biophys Res Commun. 440:125–131. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Zhang J and Li Y: Therapeutic uses of FGFs. Semin Cell Dev Biol. 53:144–154. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Hart KC, Robertson SC and Donoghue DJ: Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. Mol Biol Cell. 12:931–942. 2001. View Article : Google Scholar : PubMed/NCBI

54 

Webster MK and Donoghue DJ: Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia. EMBO J. 15:520–527. 1996.PubMed/NCBI

55 

Kang S, Elf S, Dong S, Hitosugi T, Lythgoe K, Guo A, Ruan H, Lonial S, Khoury HJ, Williams IR, et al: Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation. Mol Cell Biol. 29:2105–2117. 2009. View Article : Google Scholar : PubMed/NCBI

56 

Airoldi I, Di Carlo E, Banelli B, Moserle L, Cocco C, Pezzolo A, Sorrentino C, Rossi E, Romani M, Amadori A and Pistoia V: The IL-12Rbeta2 gene functions as a tumor suppressor in human B cell malignancies. J Clin Invest. 113:1651–1659. 2004. View Article : Google Scholar : PubMed/NCBI

57 

Jo SH, Schatz JH, Acquaviva J, Singh H and Ren R: Cooperation between deficiencies of IRF-4 and IRF-8 promotes both myeloid and lymphoid tumorigenesis. Blood. 116:2759–2767. 2010. View Article : Google Scholar : PubMed/NCBI

58 

Mangiavacchi A, Sorci M, Masciarelli S, Larivera S, Legnini I, Iosue I, Bozzoni I, Fazi F and Fatica A: The miR-223 host non-coding transcript linc-223 induces IRF4 expression in acute myeloid leukemia by acting as a competing endogenous RNA. Oncotarget. 7:60155–60168. 2016. View Article : Google Scholar : PubMed/NCBI

59 

Otto N, Manukjan G, Göhring G, Hofmann W, Scherer R, Luna JC, Lehmann U, Ganser A, Welte K, Schlegelberger B and Steinemann D: ICSBP promoter methylation in myelodysplastic syndromes and acute myeloid leukaemia. Leukemia. 25:1202–1207. 2011. View Article : Google Scholar : PubMed/NCBI

60 

Pogosova-Agadjanyan EL, Kopecky KJ, Ostronoff F, Appelbaum FR, Godwin J, Lee H, List AF, May JJ, Oehler VG, Petersdorf S, et al: The prognostic significance of IRF8 transcripts in adult patients with acute myeloid leukemia. PLoS One. 8:e708122013. View Article : Google Scholar : PubMed/NCBI

61 

Xu L, Gu ZH, Li Y, Zhang JL, Chang CK, Pan CM, Shi JY, Shen Y, Chen B, Wang YY, et al: Genomic landscape of CD34+ hematopoietic cells in myelodysplastic syndrome and gene mutation profiles as prognostic markers. Proc Natl Acad Sci USA. 111:8589–8594. 2014. View Article : Google Scholar : PubMed/NCBI

62 

Cancer Genome Atlas Research Network, . Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson A, Hoadley K, Triche TJ Jr, Laird PW, et al: Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med. 368:2059–2074. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Zhao L, Wei X, Guo Q, Zhu X, Wei R, Yin X, Zhang Y, Wang B, Li X, Li X, et al: Integrated bioinformatic analysis of microarray data reveals shared gene signature between MDS and AML. Oncol Lett 16: 5147-5159, 2018.
APA
Zhang, Z., Zhao, L., Wei, X., Guo, Q., Zhu, X., Wei, R. ... Li, X. (2018). Integrated bioinformatic analysis of microarray data reveals shared gene signature between MDS and AML. Oncology Letters, 16, 5147-5159. https://doi.org/10.3892/ol.2018.9237
MLA
Zhang, Z., Zhao, L., Wei, X., Guo, Q., Zhu, X., Wei, R., Yin, X., Zhang, Y., Wang, B., Li, X."Integrated bioinformatic analysis of microarray data reveals shared gene signature between MDS and AML". Oncology Letters 16.4 (2018): 5147-5159.
Chicago
Zhang, Z., Zhao, L., Wei, X., Guo, Q., Zhu, X., Wei, R., Yin, X., Zhang, Y., Wang, B., Li, X."Integrated bioinformatic analysis of microarray data reveals shared gene signature between MDS and AML". Oncology Letters 16, no. 4 (2018): 5147-5159. https://doi.org/10.3892/ol.2018.9237
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Zhao L, Wei X, Guo Q, Zhu X, Wei R, Yin X, Zhang Y, Wang B, Li X, Li X, et al: Integrated bioinformatic analysis of microarray data reveals shared gene signature between MDS and AML. Oncol Lett 16: 5147-5159, 2018.
APA
Zhang, Z., Zhao, L., Wei, X., Guo, Q., Zhu, X., Wei, R. ... Li, X. (2018). Integrated bioinformatic analysis of microarray data reveals shared gene signature between MDS and AML. Oncology Letters, 16, 5147-5159. https://doi.org/10.3892/ol.2018.9237
MLA
Zhang, Z., Zhao, L., Wei, X., Guo, Q., Zhu, X., Wei, R., Yin, X., Zhang, Y., Wang, B., Li, X."Integrated bioinformatic analysis of microarray data reveals shared gene signature between MDS and AML". Oncology Letters 16.4 (2018): 5147-5159.
Chicago
Zhang, Z., Zhao, L., Wei, X., Guo, Q., Zhu, X., Wei, R., Yin, X., Zhang, Y., Wang, B., Li, X."Integrated bioinformatic analysis of microarray data reveals shared gene signature between MDS and AML". Oncology Letters 16, no. 4 (2018): 5147-5159. https://doi.org/10.3892/ol.2018.9237
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