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Adjuvant transarterial chemoembolization to improve the prognosis of hepatocellular carcinoma following curative resection

  • Authors:
    • Xuejun Kuang
    • Jiazhou Ye
    • Zhibo Xie
    • Tao Bai
    • Jie Chen
    • Wenfeng Gong
    • Lunan Qi
    • Jianhong Zhong
    • Liang Ma
    • Ningfu Peng
    • Bangde Xiang
    • Feixiang Wu
    • Guobin Wu
    • Haihong Ye
    • Changmiao Wang
    • Lunqun Li
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The Affiliated Hospital of Xiangnan University, Chenzhou, Hunan 423000, P.R. China, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Minzu Hospital of Guangxi Medical University, Nanning, Guangxi 530001, P.R. China, Department of General Surgery, The First Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
    Copyright: © Kuang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4937-4944
    |
    Published online on: August 1, 2018
       https://doi.org/10.3892/ol.2018.9244
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Abstract

The present study aimed to investigate the prognostic factors for recurrence of hepatocellular carcinoma (HCC) following curative resection, and evaluate the efficacy of postoperative adjuvant transarterial chemoembolization (TACE) in improving prognosis. A total of 166 patients who underwent curative resection followed by adjuvant TACE, and 190 patients who underwent curative resection alone were studied retrospectively. Univariate and multivariate analyses were performed to investigate the risk factors of recurrence. Separated based on risk factors, subgroup studies were conducted and the association between TACE and recurrence rates was examined. Postoperative overall survival rates were determined using the Kaplan‑Meier method and differences between the two therapeutic strategies were identified through log‑rank analysis. Computerized tomography (CT)/magnetic resonance imaging (MRI) images were used to evaluate the function of postoperative adjuvant TACE for enhancing the efficacy of CT/MRI in detecting recurrence. The results of the univariate and multivariate analyses revealed that tumor capsule invasion, vascular invasion, and multiple nodules were risk factors of early recurrence. For patients with these risk factors, recurrence rates were markedly decreased at 6 and 12 months, but not at 18 and 24 months, if TACE was added to curative resection. The hepatitis B virus (HBV) was a risk factor for late recurrence. Postoperative TACE was not effective in reducing the recurrence rate in patients with HBV. Survival increased following curative resection with TACE compared with curative resection alone. Furthermore, adjuvant TACE enhanced the efficacy of CT/MRI in detecting recurrence. Postoperative adjuvant TACE may improve the prognosis of HCC following curative resection.
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1 

Qin A, Zhu J, Liu X, Zeng D, Gu M and Lv C: MicroRNA-1271 inhibits cellular proliferation of hepatocellular carcinoma. Oncol Lett. 14:67832017.PubMed/NCBI

2 

Hasegawa K, Kokudo N, Makuuchi M, Izumi N, Ichida T, Kudo M, Ku Y, Sakamoto M, Nakashima O, Matsui O and Matsuyama Y: Comparison of resection and ablation for hepatocellular carcinoma: A cohort study based on a Japanese nationwide survey. J Hepatol. 58:724–729. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Arnaoutakis DJ, Mavros MN, Shen F, Alexandrescu S, Firoozmand A, Popescu I, Weiss M, Wolfgang CL, Choti MA and Pawlik TM: Recurrence patterns and prognostic factors in patients with hepatocellular carcinoma in noncirrhotic liver: A multiinstitutional analysis. Ann Surg Oncol. 21:147–154. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Jiang JH, Guo Z, Lu HF, Wang XB, Yang HJ, Yang FQ, Bao SY, Zhong JH, Li LQ, Yang RR and Xiang BD: Adjuvant transarterial chemoembolization after curative resection of hepatocellular carcinoma: Propensity score analysis. World J Gastroenterol. 21:4627–4634. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Zhong JH and Li LQ: Postoperative adjuvant transarterial chemoembolization for participants with hepatocellular carcinoma: A meta-analysis. Hepatol Res. 40:943–953. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Lu X, Zhao H, Yang H, Mao Y, Sang X, Miao R, Xu Y, Du S, Xu H, Chi T, et al: A prospective clinical study on early recurrence of hepatocellular carcinoma after hepatectomy. J Surg Oncol. 100:488–493. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Chen X, Zhang B, Yin X, Ren Z, Qiu S and Zhou J: Lipiodolized transarterial chemoembolization in hepatocellular carcinoma patients after curative resection. J Cancer Res Clin Oncol. 139:773–781. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Ono T, Yamanoi A, El Assal Nazmy O, Kohno H and Nagasue N: Adjuvant chemotherapy after resection of hepatocellular carcinoma causes deterioration of long-term prognosis in cirrhotic patients: Metaanalysis of three randomized controlled trials. Cancer. 91:2378–2385. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Peng JW, Lin GN and Jiang XM: Hepatitis B virus reactivation in hepatocellular carcinoma patients underg oing transcatheterarterial chemoembolization therapy. Asia Pac J Clin Onco. 8:356–361. 2012. View Article : Google Scholar

10 

Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET and Carbone PP: Toxicity and response criteria of the eastern cooperative oncology group. Am J Clin Oncol. 5:649–655. 1982. View Article : Google Scholar : PubMed/NCBI

11 

Lin ZZ, Hsu C, Hu FC, Shao YY, Chang DY, Yang CH, Hong RL, Hsu CH and Cheng AL: Factors impacting prognosis prediction in BCLC stage C and Child-Pugh class A hepatocellular carcinoma patients in prospective clinical trials of systemic therapy. Oncologist. 17:970–977. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Shah SA, Greig PD, Gallinger S, Cattral MS, Dixon E, Kim RD, Taylor BR, Grant DR and Vollmer CM: Factors associated with early recurrence after resection for hepatocellular carcinoma and outcomes. J Am Coll Surg. 202:275–283. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Zhong JH, Ke Y, Gong WF, Xiang BD, Ma L, Ye XP, Peng T, Xie GS and Li LQ: Hepatic resection associated with good survival for selected patients with intermediate and advanced-stage hepatocellular carcinoma. Ann Surg. 260:329–340. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Zhu SL, Zhong JH, Ke Y, Xiao HM, Ma L, Chen J, You XM and Li LQ: Comparative efficacy of postoperative transarterial chemoembolization with or without antiviral therapy for hepatitis B virus-related hepatocellular carcinoma. Tumour Biol. 36:6277–6284. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Li DH and Sun B: Research progress in intrahepatic metastasis and multiple centre carcinogenesis of hepatocellular carcinoma. Int J Surg. 33:28–31. 2006.

16 

Sutcliffe R, Maguire D, Murphy P, Portmann B, Rela M, O'Sullivan G, Mufti G and Heaton N: Detection and clinical significance of bone marrow micrometastases in patients undergoing liver transplantation for hepatocellular carcinoma. Transplantation. 80:88–94. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Ding T, Xu J, Zhang Y, Guo RP, Wu WC, Zhang SD, Qian CN and Zheng L: Endothelium-coated tumor clusters are associated with poor prognosis and micrometastasis of hepatocellular carcinoma after resection. Cancer. 117:4878–4889. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Lee DS and Seong J: Radiotherapeutic options for hepatocellular carcinoma with portal vein tumor thrombosis. Liver Cancer. 3:18–30. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Roayaie S, Frischer JS, Emre SH, Fishbein TM, Sheiner PA, Sung M, Miller CM and Schwartz ME: Long-term results with multimodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinomas larger than 5 centimeters. Ann Surg. 235:533–539. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Cheng HY, Wang X, Chen D, Xu AM and Jia YC: The value and limitation of transcatheter arterial chemoembolization in preventing recurrence of resected hepatocellular carcinoma. World J Gastroenterol. 11:3644–3646. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Ren ZG, Lin ZY, Xia JL, Ye SL, Ma ZC and Ye QH: Postoperative adjuvant arterial chemoembolization improves survival of hepatocellular carcinoma patients with risk factors for residual tumor: A retrospective control study. World J Gastroenterol. 10:2791–2794. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Luo J, Guo RP, Lai EC, Zhang YJ, Lau WY, Chen MS and Shi M: Transarterial chemoembolization for unresectable hepatocellular carcinoma with portal vein tumor thrombosis: A prospective comparative study. Ann Surg Oncol. 18:413–420. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Norton L: Adjuvant breast cancer therapy: Current status and future strategies-growth kinetics and the improved drug therapy of breast cancer. Semin Oncol. 26 1 Suppl 3:S1–S4. 1999.

24 

Dai D, Xu W, Liu J, Zhu L, Zhu X and Ma X: Safety and efficacy of a peripheral intravenous bolus of Licartin for the treatment of advanced hepatocellular carcinoma. Exp Ther Med. 6:1417–1422. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Tanaka K, Shimada H, Togo S, Takahashi T, Endo I and Sekido H: Use of transcatheter arterial infusion of anticancer agents with lipiodol to prevent recurrence of hepatocellular carcinoma after hepatic resection. Hepatogastroenterology. 46:1083–1088. 1999.PubMed/NCBI

26 

Izumi R, Shimizu K and Miyazaki I: Postoperative adjuvant locoregional chemotherapy in patients with hepatocellular carcinoma. Hepatogastroenterology. 43:1415–1420. 1996.PubMed/NCBI

27 

Yamanaka J, Yamanaka N, Nakasho K, Tanaka T, Ando T, Yasui C, Kuroda N, Takata M, Maeda S, Matsushita K, et al: Clinicopathologic analysis of stage II–III hepatocellular carcinoma showing early massive recurrence after liver resection. J Gastroenterol Hepatol. 15:1192–1198. 2000. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kuang X, Ye J, Xie Z, Bai T, Chen J, Gong W, Qi L, Zhong J, Ma L, Peng N, Peng N, et al: Adjuvant transarterial chemoembolization to improve the prognosis of hepatocellular carcinoma following curative resection. Oncol Lett 16: 4937-4944, 2018.
APA
Kuang, X., Ye, J., Xie, Z., Bai, T., Chen, J., Gong, W. ... Li, L. (2018). Adjuvant transarterial chemoembolization to improve the prognosis of hepatocellular carcinoma following curative resection. Oncology Letters, 16, 4937-4944. https://doi.org/10.3892/ol.2018.9244
MLA
Kuang, X., Ye, J., Xie, Z., Bai, T., Chen, J., Gong, W., Qi, L., Zhong, J., Ma, L., Peng, N., Xiang, B., Wu, F., Wu, G., Ye, H., Wang, C., Li, L."Adjuvant transarterial chemoembolization to improve the prognosis of hepatocellular carcinoma following curative resection". Oncology Letters 16.4 (2018): 4937-4944.
Chicago
Kuang, X., Ye, J., Xie, Z., Bai, T., Chen, J., Gong, W., Qi, L., Zhong, J., Ma, L., Peng, N., Xiang, B., Wu, F., Wu, G., Ye, H., Wang, C., Li, L."Adjuvant transarterial chemoembolization to improve the prognosis of hepatocellular carcinoma following curative resection". Oncology Letters 16, no. 4 (2018): 4937-4944. https://doi.org/10.3892/ol.2018.9244
Copy and paste a formatted citation
x
Spandidos Publications style
Kuang X, Ye J, Xie Z, Bai T, Chen J, Gong W, Qi L, Zhong J, Ma L, Peng N, Peng N, et al: Adjuvant transarterial chemoembolization to improve the prognosis of hepatocellular carcinoma following curative resection. Oncol Lett 16: 4937-4944, 2018.
APA
Kuang, X., Ye, J., Xie, Z., Bai, T., Chen, J., Gong, W. ... Li, L. (2018). Adjuvant transarterial chemoembolization to improve the prognosis of hepatocellular carcinoma following curative resection. Oncology Letters, 16, 4937-4944. https://doi.org/10.3892/ol.2018.9244
MLA
Kuang, X., Ye, J., Xie, Z., Bai, T., Chen, J., Gong, W., Qi, L., Zhong, J., Ma, L., Peng, N., Xiang, B., Wu, F., Wu, G., Ye, H., Wang, C., Li, L."Adjuvant transarterial chemoembolization to improve the prognosis of hepatocellular carcinoma following curative resection". Oncology Letters 16.4 (2018): 4937-4944.
Chicago
Kuang, X., Ye, J., Xie, Z., Bai, T., Chen, J., Gong, W., Qi, L., Zhong, J., Ma, L., Peng, N., Xiang, B., Wu, F., Wu, G., Ye, H., Wang, C., Li, L."Adjuvant transarterial chemoembolization to improve the prognosis of hepatocellular carcinoma following curative resection". Oncology Letters 16, no. 4 (2018): 4937-4944. https://doi.org/10.3892/ol.2018.9244
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