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Article

Expression of vasohibin‑1 and ‑2 predicts poor prognosis among patients with squamous cell carcinoma of the esophagus

  • Authors:
    • Yamato Ninomiya
    • Soji Ozawa
    • Junya Oguma
    • Akihito Kazuno
    • Miho Nitta
    • Hiroshi Kajiwara
    • Yasufumi Sato
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259‑1193, Japan, Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa 259‑1143, Japan, Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi 980‑9575, Japan
  • Pages: 5265-5274
    |
    Published online on: August 1, 2018
       https://doi.org/10.3892/ol.2018.9249
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Abstract

Vasohibin (VASH) ‑1 and ‑2 are novel angiogenic regulators. The aim of the present study was to assess the prognostic values of VASH1 expression and VASH2 expression in esophageal squamous cell carcinoma (ESCC). A total of 209 patients with ESCC were investigated. Resected tumor specimens were immunostained using anti‑CD34 antibody, anti‑VASH1 antibody and anti‑VASH2 antibody. The ratio of the microvessels density and the VASH1 density as the VASH1‑positive ratio were defined and the patients were divided into two groups (a high VASH1 group and a low VASH1 group) according to the average value. The patients were also divided into two groups (a high VASH2 group and a low VASH2 group) according to VASH2 expression upon immunostaining. The clinical outcomes of these two groups were then evaluated. The high VASH1 group contained 106 patients (50.7%). The high VASH2 group contained 48 patients (23.0%). Long‑term survival was significantly poorer in the high VASH1 group compared with that in the low VASH1 group. A slight correlation between VASH1 expression and VASH2 expression was observed. The low VASH1/low VASH2 group had a better prognosis than the other three groups with different combinations of VASH1 and VASH2 expression levels. The present study showed that high VASH1 expression and high VASH2 expression may be novel independent predictors of a poor prognosis in patients with ESCC and that a slight correlation between VASH1 and VASH2 expression existed. The present findings suggest that combined evaluation of VASH1 and VASH2 expression should provide an improved understanding of their clinicopathological features.
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1 

Tachimori Y, Ozawa S, Numasaki H, Fujishiro M, Matsubara H, Oyama T, Shinoda M, Toh Y, Udagawa H and Uno T; Registration Committee for Esophageal Cancer of the Japan Esophageal Society, : Comprehensive registry of esophageal cancer in japan, 2009. Esophagus. 13:110–137. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Ito Y, Miyashiro I, Ito H, Hosono S, Chihara D, Nakata-Yamada K, Nakayama M, Matsuzaka M, Hattori M, Sugiyama H, et al: Long-term survival and conditional survival of cancer patients in Japan using population-based cancer registry data. Cancer Sci. 105:1480–1486. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Ellis LM and Hicklin DJ: VEGF-targeted therapy: Mechanisms of anti-tumor activity. Nat Rev Cancer. 8:579–591. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Shih C, Ozawa S, Ando N, Ueda M and Kitajima M: Vascular endothelial growth factor expression predicts outcome and lymph node metastasis in squamous cell carcinoma of the esophagus. Clin Cancer Res. 6:1161–1168. 2000.PubMed/NCBI

5 

Takeuchi H, Ozawa S, Shih CH, Ando N, Kitagawa Y, Ueda M and Kitajima M: Loss of p16INK4a expression is associated with vascular endothelial growth factor expression in squamous cell carcinoma of the esophagus. Int J Cancer. 109:483–490. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Watanabe K, Hasegawa Y, Yamashita H, Shimizu K, Ding Y, Abe M, Ohta H, Imagawa K, Hojo K, Maki H, et al: Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis. J Clin Invest. 114:898–907. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Sato Y: The vasohibin family: Novel regulators of angiogenesis. Vascul Pharmacol. 56:262–266. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Kimura H, Miyashita H, Suzuki Y, Kobayashi M, Watanabe K, Sonoda H, Ohta H, Fujiwara T, Shimosegawa T and Sato Y: Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis. Blood. 113:4810–4818. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Shimizu K, Watanabe K, Yamashita H, Abe M, Yoshimatsu H, Ohta H, Sonoda H and Sato Y: Gene regulation of a novel angiogenesis inhibitor, vasohibin, in endothelial cells. Biochem Biophys Res Commun. 327:700–706. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Tamaki K, Moriya T, Sato Y, Ishida T, Maruo Y, Yoshinaga K, Ohuchi N and Sasano H: Vasohibin-1 in human breast carcinoma: A potential negative feedback regulator of angiogenesis. Cancer Sci. 100:88–94. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Murakami K, Kasajima A, Kawagishi N, Sekiguchi S, Fujishima F, Watanabe M, Sato Y, Ohuchi N and Sasano H: The prognostic significance of vasohibin 1-associated angiogenesis in patients with hepatocellular carcinoma. Hum Pathol. 45:589–597. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Miyazaki Y, Kosaka T, Mikami S, Kikuchi E, Tanaka N, Maeda T, Ishida M, Miyajima A, Nakagawa K, Okada Y, et al: The prognostic significance of vasohibin-1 expression in patients with upper urinary tract urothelial carcinoma. Clin Cancer Res. 18:4145–4153. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Kosaka T, Miyazaki Y, Miyajima A, Mikami S, Hayashi Y, Tanaka N, Nagata H, Kikuchi E, Nakagawa K, Okada Y, et al: The prognostic significance of vasohibin-1 expression in patients with prostate cancer. Br J Cancer. 108:2123–2129. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Kitajima T, Toiyama Y, Tanaka K, Saigusa S, Kobayashi M, Inoue Y, Mohri Y and Kusunoki M: Vasohibin-1 increases the malignant potential of colorectal cancer and is a biomarker of poor prognosis. Anticancer Res. 34:5321–5329. 2014.PubMed/NCBI

15 

Zhang T, Yu TT, Zhang DM, Hou XM, Liu XJ, Zhao D and Shan L: Vasohibin-1 expression detected by immunohistochemistry correlates with prognosis in non-small cell lung cancer. Med Oncol. 31:9632014. View Article : Google Scholar : PubMed/NCBI

16 

Mikami S, Oya M, Kosaka T, Mizuno R, Miyazaki Y, Sato Y and Okada Y: Increased vasohibin-1 expression is associated with metastasis and poor prognosis of renal cell carcinoma patients. Lab Invest. 13:854–862. 2017. View Article : Google Scholar

17 

Torii C, Hida Y, Shindoh M, Akiyama K, Ohga N, Maishi N, Ohiro Y, Ono M, Totsuka Y, Kitagawa Y, et al: Vasohibin-1 as a novel prognostic factor for head and neck squamous cell carcinoma. Anticancer Res. 37:1219–1225. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Kim JC, Kim KT, Park JT, Kim HJ, Sato Y and Kim HS: Expression of vasohibin-2 in pancreatic ductal adenocarcinoma promotes tumor progression and is associated with a poor clinical outcome. Hepatogastroenterology. 62:251–256. 2015.PubMed/NCBI

19 

Japan Esophageal Society, . Japanese classification of esophageal cancer, 11th edition: Part I. Esophagus. 14:1–36. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Japan Esophageal Society, . Japanese classification of esophageal cancer, 11th edition: Part II and III. Esophagus. 14:37–65. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Koyanagi T, Suzuki Y, Komori K, Saga Y, Matsubara S, Fujiwara H and Sato Y: Targeting human vasohibin-2 by a neutralizing monoclonal antibody for anti-cancer treatment. Cancer Sci. 108:512–519. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Yoshinaga K, Ito K, Moriya T, Nagase S, Takano T, Niikura H, Sasano H, Yaegashi and Sato Y: Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas. Cancer Sci. 102:446–451. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Weidner N, Semple JP, Welch WR and Folkman J: Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med. 324:1–8. 1991. View Article : Google Scholar : PubMed/NCBI

24 

Sato Y: Is vasohibin-1 more than angiogenesis inhibition? J Biochem. 149:229–230. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Roviello G, Petrioli R, Marano L, Polom K, Marrelli D, Perrella A and Roviello F: Angiogenesis inhibitors in gastric and gastroesophageal junction cancer. Gastric Cancer. 19:31–41. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Reck M, von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsh V, Leighl N, Mezger J, Archer V, Moore N, et al: Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: Results from a randomised phase III trial (AVAiL). Ann Oncol. 21:1804–1809. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Kabbinavar FF, Hambleton J, Mass RD, Hurwitz Hl, Bergsland E and Sarkar S: Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol. 23:3706–3712. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Nasu T, Maeshima Y, Kinomura M, Hirokoshi-Kawahara K, Tanabe K, Sugiyama H, Sonoda H, Sato Y and Makino H: Vasohibin-1, a negative feedback regulator of angiogenesis, ameliorates renal alterations in a mouse model of diabetic nephropathy. Diabetes. 58:2365–2375. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Hosaka T, Kimura H, Heishi T, Suzuki Y, Miyashita H, Ohta H, Sonoda H, Moriya T, Suzuki S, Kondo T and Sato Y: Vasohibin-1 expression in endothelium of tumor blood vessels regulates angiogenesis. Am J Pathol. 175:430–439. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Ho JW, Poon RT, Sun CK, Xue WC and Fan ST: Clinicopathological and prognostic implications of endoglin (CD105) expression in hepatocellular carcinoma and its adjacent non-tumorous liver. World J Gastroenterol. 11:176–181. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Saito M, Suzuki Y, Yano S, Miyazaki T and Sato Y: Proteolytic inactivation of anti-angiogenic vasohibin-1 by cancer cells. J Biochem. 160:227–232. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Takahashi Y, Koyanagi T, Suzuki Y, Saga Y, Kanomata N, Moriya T, Suzuki M and Sato Y: Vasohibin-2 expressed in human serous ovarian adenocarcinoma accelerates tumor growth by promoting angiogenesis. Mol Cancer Res. 10:1135–1146. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Xue X, Gao W, Sun B, Xu Y, Han B, Wang F, Zhang Y, Sun J, Wei J, Li Z, et al: Vasohibin 2 is transcriptionally activated and promotes angiogenesis in hepatocellular carcinoma. Oncogene. 32:1724–1734. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Tu M, Lu C, Lv N, Wei J, Lu Z, Xi C, Chen J, Guo F, Jiang K, Li Q, et al: Vasohibin 2 promotes human luminal breast cancer angiogenesis in a non-paracrine manner via transcriptional activation of fibroblast growth factor 2. Cancer Lett. 383:272–281. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Norita R, Suzuki Y, Furutani Y, Takahashi K, Yoshimatsu Y, Podyma-Inoue KA, Watabe T and Sato Y: Vasohibin-2 is required for epithelial-mesenchymal transition of ovarian cancer cells by modulating transforming growth factor-β signaling. Cancer Sci. 108:419–426. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Koyanagi T, Saga Y, Takahashi Y, Suzuki Y, Suzuki M and Sato Y: Downregulation of vasohibin-2, a novel angiogenesis regulator, suppresses tumor growth by inhibiting angiogenesis in endometrial cancer cells. Oncol Lett. 5:1058–1062. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ninomiya Y, Ozawa S, Oguma J, Kazuno A, Nitta M, Kajiwara H and Sato Y: Expression of vasohibin‑1 and ‑2 predicts poor prognosis among patients with squamous cell carcinoma of the esophagus. Oncol Lett 16: 5265-5274, 2018.
APA
Ninomiya, Y., Ozawa, S., Oguma, J., Kazuno, A., Nitta, M., Kajiwara, H., & Sato, Y. (2018). Expression of vasohibin‑1 and ‑2 predicts poor prognosis among patients with squamous cell carcinoma of the esophagus. Oncology Letters, 16, 5265-5274. https://doi.org/10.3892/ol.2018.9249
MLA
Ninomiya, Y., Ozawa, S., Oguma, J., Kazuno, A., Nitta, M., Kajiwara, H., Sato, Y."Expression of vasohibin‑1 and ‑2 predicts poor prognosis among patients with squamous cell carcinoma of the esophagus". Oncology Letters 16.4 (2018): 5265-5274.
Chicago
Ninomiya, Y., Ozawa, S., Oguma, J., Kazuno, A., Nitta, M., Kajiwara, H., Sato, Y."Expression of vasohibin‑1 and ‑2 predicts poor prognosis among patients with squamous cell carcinoma of the esophagus". Oncology Letters 16, no. 4 (2018): 5265-5274. https://doi.org/10.3892/ol.2018.9249
Copy and paste a formatted citation
x
Spandidos Publications style
Ninomiya Y, Ozawa S, Oguma J, Kazuno A, Nitta M, Kajiwara H and Sato Y: Expression of vasohibin‑1 and ‑2 predicts poor prognosis among patients with squamous cell carcinoma of the esophagus. Oncol Lett 16: 5265-5274, 2018.
APA
Ninomiya, Y., Ozawa, S., Oguma, J., Kazuno, A., Nitta, M., Kajiwara, H., & Sato, Y. (2018). Expression of vasohibin‑1 and ‑2 predicts poor prognosis among patients with squamous cell carcinoma of the esophagus. Oncology Letters, 16, 5265-5274. https://doi.org/10.3892/ol.2018.9249
MLA
Ninomiya, Y., Ozawa, S., Oguma, J., Kazuno, A., Nitta, M., Kajiwara, H., Sato, Y."Expression of vasohibin‑1 and ‑2 predicts poor prognosis among patients with squamous cell carcinoma of the esophagus". Oncology Letters 16.4 (2018): 5265-5274.
Chicago
Ninomiya, Y., Ozawa, S., Oguma, J., Kazuno, A., Nitta, M., Kajiwara, H., Sato, Y."Expression of vasohibin‑1 and ‑2 predicts poor prognosis among patients with squamous cell carcinoma of the esophagus". Oncology Letters 16, no. 4 (2018): 5265-5274. https://doi.org/10.3892/ol.2018.9249
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