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miR‑199b‑5p inhibits triple negative breast cancer cell proliferation, migration and invasion by targeting DDR1

  • Authors:
    • Anhao Wu
    • Yan Chen
    • Yang Liu
    • Yafang Lai
    • Dequan Liu
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery Ward I, The Third Affiliated Hospital, Kunming Medical University, Tumor Hospital of Yunnan Kunming Province, Kunming, Yunnan 650100, P.R. China, Cancer Institute, Third Affiliated Hospital, Kunming Medical University, Tumor Hospital of Yunnan Kunming Province, Kunming, Yunnan 650100, P.R. China, Public Health, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4889-4896
    |
    Published online on: August 2, 2018
       https://doi.org/10.3892/ol.2018.9255
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Abstract

Triple negative breast cancer (TNBC) has received increasing attention from oncologists worldwide due to its poor prognosis and paucity of targeted therapies. MicroRNAs (miRs) are a group of small non‑coding RNAs that are responsible for the post‑transcriptional regulation of various target genes. The present study demonstrated that the expression of miR‑199b‑5p in breast cancer tissue was significantly reduced compared with that in normal breast tissues by reverse transcription‑quantitative polymerase chain reaction. In addition, western blot analysis and luciferase reporter assays revealed that miR‑199b‑5p in TNBC cells inhibited discoidin domain receptor tyrosine kinase 1 expression by directly targeting its 3'‑untranslated region. Furthermore, miR‑199b‑5p markedly suppressed the proliferation and invasion of TNBC cells, as demonstrated by using wound‑healing, migration, invasion and proliferation assays. Collectively, these results indicate that miR‑199b‑5p may be a novel alternative therapeutic target for TNBC.
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Copy and paste a formatted citation
Spandidos Publications style
Wu A, Chen Y, Liu Y, Lai Y and Liu D: miR‑199b‑5p inhibits triple negative breast cancer cell proliferation, migration and invasion by targeting DDR1. Oncol Lett 16: 4889-4896, 2018.
APA
Wu, A., Chen, Y., Liu, Y., Lai, Y., & Liu, D. (2018). miR‑199b‑5p inhibits triple negative breast cancer cell proliferation, migration and invasion by targeting DDR1. Oncology Letters, 16, 4889-4896. https://doi.org/10.3892/ol.2018.9255
MLA
Wu, A., Chen, Y., Liu, Y., Lai, Y., Liu, D."miR‑199b‑5p inhibits triple negative breast cancer cell proliferation, migration and invasion by targeting DDR1". Oncology Letters 16.4 (2018): 4889-4896.
Chicago
Wu, A., Chen, Y., Liu, Y., Lai, Y., Liu, D."miR‑199b‑5p inhibits triple negative breast cancer cell proliferation, migration and invasion by targeting DDR1". Oncology Letters 16, no. 4 (2018): 4889-4896. https://doi.org/10.3892/ol.2018.9255
Copy and paste a formatted citation
x
Spandidos Publications style
Wu A, Chen Y, Liu Y, Lai Y and Liu D: miR‑199b‑5p inhibits triple negative breast cancer cell proliferation, migration and invasion by targeting DDR1. Oncol Lett 16: 4889-4896, 2018.
APA
Wu, A., Chen, Y., Liu, Y., Lai, Y., & Liu, D. (2018). miR‑199b‑5p inhibits triple negative breast cancer cell proliferation, migration and invasion by targeting DDR1. Oncology Letters, 16, 4889-4896. https://doi.org/10.3892/ol.2018.9255
MLA
Wu, A., Chen, Y., Liu, Y., Lai, Y., Liu, D."miR‑199b‑5p inhibits triple negative breast cancer cell proliferation, migration and invasion by targeting DDR1". Oncology Letters 16.4 (2018): 4889-4896.
Chicago
Wu, A., Chen, Y., Liu, Y., Lai, Y., Liu, D."miR‑199b‑5p inhibits triple negative breast cancer cell proliferation, migration and invasion by targeting DDR1". Oncology Letters 16, no. 4 (2018): 4889-4896. https://doi.org/10.3892/ol.2018.9255
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