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Prognostic impact of programmed cell death ligand 1 expression on long‑term oncologic outcomes in colorectal cancer

  • Authors:
    • Sung Uk Bae
    • Woon Kyung Jeong
    • Seong Kyu Baek
    • Nam Kyu Kim
    • Ilseon Hwang
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 41931, Republic of Korea, Division of Colorectal Surgery, Department of Surgery, Colorectal Cancer Clinic, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea, Department of Pathology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 41931, Republic of Korea
    Copyright: © Bae et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5214-5222
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    Published online on: August 3, 2018
       https://doi.org/10.3892/ol.2018.9264
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Abstract

The present study evaluated the association between programmed cell death ligand‑1 (PD‑L1) expression and long‑term oncologic outcomes in colorectal cancer (CRC). PD‑L1 expression was evaluated using immunohistochemistry in 175 patients who underwent surgical resection for CRC between September 1999 and August 2004. Patients were grouped according to PD‑L1 expression, with 82 (46.9%) and 93 (53.1%) in the low and high PD‑L1 expression groups, respectively. The overall survival (OS) and disease‑free survival (DFS) rates were significantly better in the high expression group compared with in the low expression group (OS: 48.2 vs. 32.9%, P=0.047; DFS: 43.3 vs. 32.9%, P=0.021). According to the Tumor‑Node‑Metastasis stage subgroups, the OS rates in the low and high expression groups, respectively, were 66.7 and 60.0% in stage I (P=0.715), 51.8 and 46.7% in stage II (P=0.789), 19.6 and 51.1% in stage III (P=0.011) and 9.1 and 0% in stage IV (P=0.005). The DFS rates in the low and high expression groups, respectively, were 66.7 and 60.0% in stage I (P=0.715), 51.8 and 46.7% in stage II (P=0.857), 19.6 and 38.3% in stage III (P=0.006) and 9.1 and 0% in stage IV (P=0.700). The systemic recurrence rate was significantly higher in the low expression group compared with in the high expression group (42.7 vs. 12.9%, respectively, P=0.030). Low PD‑L1 expression was significantly associated with tumor relapse and poor prognosis in stage III CRC.
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1 

Shin A, Kim KZ, Jung KW, Park S, Won YJ, Kim J, Kim DY and Oh JH: Increasing trend of colorectal cancer incidence in Korea, 1999–2009. Cancer Res Treat. 44:219–226. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global patterns and trends in colorectal cancer incidence and mortality. Gut. 66:683–691. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Colussi D, Brandi G, Bazzoli F and Ricciardiello L: Molecular pathways involved in colorectal cancer: Implications for disease behavior and prevention. Int J Mol Sci. 14:16365–16385. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Di Caro G, Marchesi F, Laghi L and Grizzi F: Immune cells: Plastic players along colorectal cancer progression. J Cell Mol Med. 17:1088–1095. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Ogino S, Galon J, Fuchs CS and Dranoff G: Cancer immunology-analysis of host and tumor factors for personalized medicine. Nat Rev Clin Oncol. 8:711–719. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Zaanan A, Fléjou JF, Emile JF, Des GG, Cuilliere-Dartigues P, Malka D, Lecaille C, Validire P, Louvet C, Rougier P, et al: Defective mismatch repair status as a prognostic biomarker of disease-free survival in stage III colon cancer patients treated with adjuvant FOLFOX chemotherapy. Clin Cancer Res. 17:7470–7478. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Sinicrope FA, Shi Q, Smyrk TC, Thibodeau SN, Dienstmann R, Guinney J, Bot BM, Tejpar S, Delorenzi M, Goldberg RM, et al: Molecular markers identify subtypes of stage III colon cancer associated with patient outcomes. Gastroenterology. 148:88–99. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Galon J, Mlecnik B, Bindea G, Angell HK, Berger A, Lagorce C, Lugli A, Zlobec I, Hartmann A, Bifulco C, et al: Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours. J Pathol. 232:199–209. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Mlecnik B, Bindea G, Angell HK, Maby P, Angelova M, Tougeron D, Church SE, Lafontaine L, Fischer M, Fredriksen T, et al: Integrative analyses of colorectal cancer show immunoscore is a stronger predictor of patient survival than microsatellite instability. Immunity. 44:698–711. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Topalian SL, Drake CG and Pardoll DM: Immune checkpoint blockade: A common denominator approach to cancer therapy. Cancer Cell. 27:450–461. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Ostrand-Rosenberg S, Horn LA and Haile ST: The programmed death-1 immune-suppressive pathway: Barrier to antitumor immunity. J Immunol. 193:3835–3841. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Rooney MS, Shukla SA, Wu CJ, Getz G and Hacohen N: Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell. 160:48–61. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Hirano F, Kaneko K, Tamura H, Dong H, Wang S, Ichikawa M, Rietz C, Flies DB, Lau JS, Zhu G, et al: Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res. 65:1089–1096. 2005.PubMed/NCBI

14 

Konishi J, Yamazaki K, Azuma M, Kinoshita I, Dosaka-Akita H and Nishimura M: B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. Clin Cancer Res. 10:5094–5100. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Ohigashi Y, Sho M, Yamada Y, Tsurui Y, Hamada K, Ikeda N, Mizuno T, Yoriki R, Kashizuka H, Yane K, et al: Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer. Clin Cancer Res. 11:2947–2953. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Thompson RH, Gillett MD, Cheville JC, Lohse CM, Dong H, Webster WS, Krejci KG, Lobo JR, Sengupta S, Chen L, et al: Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target. Proc Natl Acad Sci USA. 101:17174–17179. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Hamanishi J, Mandai M, Iwasaki M, Okazaki T, Tanaka Y, Yamaguchi K, Higuchi T, Yagi H, Takakura K, Minato N, et al: Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci USA. 104:3360–3365. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, Lu S, Kemberling H, Wilt C, Luber BS, et al: Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science. 357:409–413. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Sabatier R, Finetti P, Mamessier E, Adelaide J, Chaffanet M, Ali HR, Viens P, Caldas C, Birnbaum D and Bertucci F: Prognostic and predictive value of PDL1 expression in breast cancer. Oncotarget. 6:5449–5464. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Hino R, Kabashima K, Kato Y, Yagi H, Nakamura M, Honjo T, Okazaki T and Tokura Y: Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma. Cancer. 116:1757–1766. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Wu P, Wu D, Li L, Chai Y and Huang J: PD-L1 and survival in solid tumors: A meta-analysis. PLoS One. 10:e01314032015. View Article : Google Scholar : PubMed/NCBI

22 

Zhu Z, Jin Z, Zhang M, Tang Y, Yang G, Yuan X, Yao J and Sun D: Prognostic value of programmed death-ligand 1 in sarcoma: A meta-analysis. Oncotarget. 8:59570–59580. 2017.PubMed/NCBI

23 

Droeser RA, Hirt C, Viehl CT, Frey DM, Nebiker C, Huber X, Zlobec I, Eppenberger-Castori S, Tzankov A, Rosso R, et al: Clinical impact of programmed cell death ligand 1 expression in colorectal cancer. Eur J Cancer. 49:2233–2242. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Lee LH, Cavalcanti MS, Segal NH, Hechtman JF, Weiser MR, Smith JJ, Garcia-Aguilar J, Sadot E, Ntiamoah P, Markowitz AJ, et al: Patterns and prognostic relevance of PD-1 and PD-L1 expression in colorectal carcinoma. Mod Pathol. 29:1433–1442. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Saigusa S, Toiyama Y, Tanaka K, Inoue Y, Mori K, Ide S, Imaoka H, Kawamura M, Mohri Y and Kusunoki M: Implication of programmed cell death ligand 1 expression in tumor recurrence and prognosis in rectal cancer with neoadjuvant chemoradiotherapy. Int J Clin Oncol. 21:946–952. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Dunne PD, McArt DG, O'Reilly PG, Coleman HG, Allen WL, Loughrey M, Van Schaeybroeck S, McDade S, Salto-Tellez M, Longley DB, et al: Immune-derived PD-L1 gene expression defines a subgroup of stage II/III colorectal cancer patients with favorable prognosis who may be harmed by adjuvant chemotherapy. Cancer Immunol Res. 4:582–591. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Koganemaru S, Inoshita N, Miura Y, Miyama Y, Fukui Y, Ozaki Y, Tomizawa K, Hanaoka Y, Toda S, Suyama K, et al: Prognostic value of programmed death-ligand 1 expression in patients with stage III colorectal cancer. Cancer Sci. 108:853–858. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Shen JK, Cote GM, Choy E, Yang P, Harmon D, Schwab J, Nielsen GP, Chebib I, Ferrone S, Wang X, et al: Programmed cell death ligand 1 expression in osteosarcoma. Cancer Immunol Res. 2:690–698. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Curiel TJ, Wei S, Dong H, Alvarez X, Cheng P, Mottram P, Krzysiek R, Knutson KL, Daniel B, Zimmermann MC, et al: Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nature Med. 9:562–567. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Song M, Chen D, Lu B, Wang C, Zhang J, Huang L, Wang X, Timmons CL, Hu J, Liu B, et al: PTEN loss increases PD-L1 protein expression and affects the correlation between PD-L1 expression and clinical parameters in colorectal cancer. PLoS One. 8:e658212013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Bae SU, Jeong WK, Baek SK, Kim NK and Hwang I: Prognostic impact of programmed cell death ligand 1 expression on long‑term oncologic outcomes in colorectal cancer. Oncol Lett 16: 5214-5222, 2018.
APA
Bae, S.U., Jeong, W.K., Baek, S.K., Kim, N.K., & Hwang, I. (2018). Prognostic impact of programmed cell death ligand 1 expression on long‑term oncologic outcomes in colorectal cancer. Oncology Letters, 16, 5214-5222. https://doi.org/10.3892/ol.2018.9264
MLA
Bae, S. U., Jeong, W. K., Baek, S. K., Kim, N. K., Hwang, I."Prognostic impact of programmed cell death ligand 1 expression on long‑term oncologic outcomes in colorectal cancer". Oncology Letters 16.4 (2018): 5214-5222.
Chicago
Bae, S. U., Jeong, W. K., Baek, S. K., Kim, N. K., Hwang, I."Prognostic impact of programmed cell death ligand 1 expression on long‑term oncologic outcomes in colorectal cancer". Oncology Letters 16, no. 4 (2018): 5214-5222. https://doi.org/10.3892/ol.2018.9264
Copy and paste a formatted citation
x
Spandidos Publications style
Bae SU, Jeong WK, Baek SK, Kim NK and Hwang I: Prognostic impact of programmed cell death ligand 1 expression on long‑term oncologic outcomes in colorectal cancer. Oncol Lett 16: 5214-5222, 2018.
APA
Bae, S.U., Jeong, W.K., Baek, S.K., Kim, N.K., & Hwang, I. (2018). Prognostic impact of programmed cell death ligand 1 expression on long‑term oncologic outcomes in colorectal cancer. Oncology Letters, 16, 5214-5222. https://doi.org/10.3892/ol.2018.9264
MLA
Bae, S. U., Jeong, W. K., Baek, S. K., Kim, N. K., Hwang, I."Prognostic impact of programmed cell death ligand 1 expression on long‑term oncologic outcomes in colorectal cancer". Oncology Letters 16.4 (2018): 5214-5222.
Chicago
Bae, S. U., Jeong, W. K., Baek, S. K., Kim, N. K., Hwang, I."Prognostic impact of programmed cell death ligand 1 expression on long‑term oncologic outcomes in colorectal cancer". Oncology Letters 16, no. 4 (2018): 5214-5222. https://doi.org/10.3892/ol.2018.9264
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