Expression levels of the long noncoding RNA steroid receptor activator promote cell proliferation and invasion and predict patient prognosis in human cervical cancer

  • Authors:
    • Hee Jung Kim
    • Lee Kyung Kim
    • San‑Hui Lee
    • Sun Ae Park
    • Kyung Jin Eoh
    • Young Tae Kim
  • View Affiliations

  • Published online on: August 3, 2018     https://doi.org/10.3892/ol.2018.9265
  • Pages: 5410-5418
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Abstract

Long noncoding RNAs (lncRNAs) are involved in developmental processes and diseases and function as critical regulators of a number of different cancer types. Previous research has revealed that lncRNAs affect cervical cancer development. Steroid receptor activator (SRA), an lncRNA, serves as a critical regulator of gynecologic cancer. However, the association between SRA expression and cervical cancer remains unclear. In the present study, the SRA expression levels in patients with cervical cancer were examined and the association between SRA expression and clinicopathological factors was determined. SRA expression was observed in cervical cancer tissues (n=100) and corresponding normal tissues (n=22) using reverse transcription‑quantitative polymerase chain reaction, and its associations with clinical parameters and prognosis were analyzed. SRA expression was significantly greater in tissues from patients with cervical cancer compared with in control patients (P<0.001). Multivariate analysis revealed that high SRA expression was an independent prognostic factor of overall survival (hazard ratio=3.714, P=0.031). The present study additionally investigated the biofunctional consequences of SRA overexpression in vitro using Cell Counting kit‑8, wound healing migration and Matrigel invasion assays. The results demonstrated that SRA overexpression enhanced cell proliferation, migration and invasion in vitro. Furthermore, SRA overexpression induced the epithelial‑mesenchymal transition (EMT). Therefore, SRA may promote tumor aggressiveness through the upregulation of EMT‑associated genes. These results indicated that SRA may represent a novel biomarker for predicting recurrence and prognosis and serve as a promising therapeutic target in cervical cancer.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Kim HJ, Kim LK, Lee SH, Park SA, Eoh KJ and Kim YT: Expression levels of the long noncoding RNA steroid receptor activator promote cell proliferation and invasion and predict patient prognosis in human cervical cancer. Oncol Lett 16: 5410-5418, 2018
APA
Kim, H.J., Kim, L.K., Lee, S., Park, S.A., Eoh, K.J., & Kim, Y.T. (2018). Expression levels of the long noncoding RNA steroid receptor activator promote cell proliferation and invasion and predict patient prognosis in human cervical cancer. Oncology Letters, 16, 5410-5418. https://doi.org/10.3892/ol.2018.9265
MLA
Kim, H. J., Kim, L. K., Lee, S., Park, S. A., Eoh, K. J., Kim, Y. T."Expression levels of the long noncoding RNA steroid receptor activator promote cell proliferation and invasion and predict patient prognosis in human cervical cancer". Oncology Letters 16.4 (2018): 5410-5418.
Chicago
Kim, H. J., Kim, L. K., Lee, S., Park, S. A., Eoh, K. J., Kim, Y. T."Expression levels of the long noncoding RNA steroid receptor activator promote cell proliferation and invasion and predict patient prognosis in human cervical cancer". Oncology Letters 16, no. 4 (2018): 5410-5418. https://doi.org/10.3892/ol.2018.9265