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Article

Expression levels of the long noncoding RNA steroid receptor activator promote cell proliferation and invasion and predict patient prognosis in human cervical cancer

  • Authors:
    • Hee Jung Kim
    • Lee Kyung Kim
    • San‑Hui Lee
    • Sun Ae Park
    • Kyung Jin Eoh
    • Young Tae Kim
  • View Affiliations / Copyright

    Affiliations: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea
  • Pages: 5410-5418
    |
    Published online on: August 3, 2018
       https://doi.org/10.3892/ol.2018.9265
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Abstract

Long noncoding RNAs (lncRNAs) are involved in developmental processes and diseases and function as critical regulators of a number of different cancer types. Previous research has revealed that lncRNAs affect cervical cancer development. Steroid receptor activator (SRA), an lncRNA, serves as a critical regulator of gynecologic cancer. However, the association between SRA expression and cervical cancer remains unclear. In the present study, the SRA expression levels in patients with cervical cancer were examined and the association between SRA expression and clinicopathological factors was determined. SRA expression was observed in cervical cancer tissues (n=100) and corresponding normal tissues (n=22) using reverse transcription‑quantitative polymerase chain reaction, and its associations with clinical parameters and prognosis were analyzed. SRA expression was significantly greater in tissues from patients with cervical cancer compared with in control patients (P<0.001). Multivariate analysis revealed that high SRA expression was an independent prognostic factor of overall survival (hazard ratio=3.714, P=0.031). The present study additionally investigated the biofunctional consequences of SRA overexpression in vitro using Cell Counting kit‑8, wound healing migration and Matrigel invasion assays. The results demonstrated that SRA overexpression enhanced cell proliferation, migration and invasion in vitro. Furthermore, SRA overexpression induced the epithelial‑mesenchymal transition (EMT). Therefore, SRA may promote tumor aggressiveness through the upregulation of EMT‑associated genes. These results indicated that SRA may represent a novel biomarker for predicting recurrence and prognosis and serve as a promising therapeutic target in cervical cancer.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Yang W, Hong L, Xu X, Wang Q, Huang J and Jiang L: LncRNA GAS5 suppresses the tumorigenesis of cervical cancer by downregulating miR-196a and miR-205. Tumour Biol. 39:10104283177113152017. View Article : Google Scholar : PubMed/NCBI

3 

Dryden-Peterson S, Bvochora-Nsingo M, Suneja G, Efstathiou JA, Grover S, Chiyapo S, Ramogola-Masire D, Kebabonye-Pusoentsi M, Clayman R, Mapes AC, et al: HIV infection and survival among women with cervical cancer. J Clin Oncol. 34:3749–3757. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Chuang LT, Feldman S, Nakisige C, Temin S and Berek JS: Management and care of women with invasive cervical cancer. J Clin Oncol. 34:3354–3355. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Perez DS, Hoage TR, Pritchett JR, Ducharme-Smith AL, Halling ML, Ganapathiraju SC, Streng PS and Smith DI: Long, abundantly expressed non-coding transcripts are altered in cancer. Hum Mol Genet. 17:642–655. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Mattick JS: The functional genomics of noncoding RNA. Science. 309:1527–1528. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Guttman M, Donaghey J, Carey BW, Garber M, Grenier JK, Munson G, Young G, Lucas AB, Ach R, Bruhn L, et al: lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature. 477:295–300. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E and Chang HY: Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell. 129:1311–1323. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Ponting CP, Oliver PL and Reik W: Evolution and functions of long noncoding RNAs. Cell. 136:629–641. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Hung T, Wang Y, Lin MF, Koegel AK, Kotake Y, Grant GD, Horlings HM, Shah N, Umbricht C, Wang P, et al: Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet. 43:621–629. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Lanz RB, McKenna NJ, Onate SA, Albrecht U, Wong J, Tsai SY, Tsai MJ and O'Malley BW: A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. Cell. 97:17–27. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Ling H, Vincent K, Pichler M, Fodde R, Berindan-Neagoe I, Slack FJ and Calin GA: Junk DNA and the long non-coding RNA twist in cancer genetics. Oncogene. 34:5003–5011. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Leygue E: Steroid receptor RNA activator (SRA1): Unusual bifaceted gene products with suspected relevance to breast cancer. Nucl Recept Signal. 5:e0062007.PubMed/NCBI

14 

Colley SM and Leedman PJ: Steroid receptor RNA activator-A nuclear receptor coregulator with multiple partners: Insights and challenges. Biochimie. 93:1966–1972. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Eoh KJ, Paek J, Kim SW, Kim HJ, Lee HY, Lee SK and Kim YT: Long non-coding RNA, steroid receptor RNA activator (SRA), induces tumor proliferation and invasion through the NOTCH pathway in cervical cancer cell lines. Oncol Rep. 38:3481–3488. 2017.PubMed/NCBI

16 

Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, et al: The transcriptional landscape of the mammalian genome. Science. 309:1559–1563. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Hall PA and Russell SH: New perspectives on neoplasia and the RNA world. Hematol Oncol. 23:49–53. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Mercer TR, Dinger ME and Mattick JS: Long non-coding RNAs: Insights into functions. Nat Rev Genet. 10:155–159. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Kim HJ, Lee DW, Yim GW, Nam EJ, Kim S, Kim SW and Kim YT: Long non-coding RNA HOTAIR is associated with human cervical cancer progression. Int J Oncol. 46:521–530. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, et al: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 464:1071–1076. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Schiffman M, Castle PE, Jeronimo J, Rodriguez AC and Wacholder S: Human papillomavirus and cervical cancer. Lancet. 370:890–907. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Lui WO, Pourmand N, Patterson BK and Fire A: Patterns of known and novel small RNAs in human cervical cancer. Cancer Res. 67:6031–6043. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Fatima R, Akhade VS, Pal D and Rao SM: Long noncoding RNAs in development and cancer: Potential biomarkers and therapeutic targets. Mol Cell Ther. 3:52015. View Article : Google Scholar : PubMed/NCBI

24 

Lee MY and Shen MR: Epithelial-mesenchymal transition in cervical carcinoma. Am J Transl Res. 4:1–13. 2012.PubMed/NCBI

25 

Ramis-Conde I, Chaplain MA, Anderson AR and Drasdo D: Multi-scale modelling of cancer cell intravasation: The role of cadherins in metastasis. Phys Biol. 6:0160082009. View Article : Google Scholar : PubMed/NCBI

26 

Calaf GM, Balajee AS, Montalvo-Villagra MT, Leon M, Daniela NM, Alvarez RG, Roy D, Narayan G and Abarca-Quinones J: Vimentin and Notch as biomarkers for breast cancer progression. Oncol Lett. 7:721–727. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Martin TA, Goyal A, Watkins G and Jiang WG: Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer. Ann Surg Oncol. 12:488–496. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Delgado G, Bundy B, Zaino R, Sevin BU, Creasman WT and Major F: Prospective surgical-pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix: A Gynecologic Oncology Group study. Gynecol Oncol. 38:352–357. 1990. View Article : Google Scholar : PubMed/NCBI

29 

Wentz WB and Reagan JW: Survival in cervical cancer with respect to cell type. Cancer. 12:384–388. 1959. View Article : Google Scholar : PubMed/NCBI

30 

Biewenga P, van der Velden J, Mol BW, Stalpers LJ, Schilthuis MS, van der Steeg JW, Burger MP and Buist MR: Prognostic model for survival in patients with early stage cervical cancer. Cancer. 117:768–776. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Kodama J, Seki N, Masahiro S, Kusumoto T, Nakamura K, Hongo A and Hiramatsu Y: Prognostic factors in stage IB-IIB cervical adenocarcinoma patients treated with radical hysterectomy and pelvic lymphadenectomy. J Surg Oncol. 101:413–417. 2010.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim HJ, Kim LK, Lee SH, Park SA, Eoh KJ and Kim YT: Expression levels of the long noncoding RNA steroid receptor activator promote cell proliferation and invasion and predict patient prognosis in human cervical cancer. Oncol Lett 16: 5410-5418, 2018.
APA
Kim, H.J., Kim, L.K., Lee, S., Park, S.A., Eoh, K.J., & Kim, Y.T. (2018). Expression levels of the long noncoding RNA steroid receptor activator promote cell proliferation and invasion and predict patient prognosis in human cervical cancer. Oncology Letters, 16, 5410-5418. https://doi.org/10.3892/ol.2018.9265
MLA
Kim, H. J., Kim, L. K., Lee, S., Park, S. A., Eoh, K. J., Kim, Y. T."Expression levels of the long noncoding RNA steroid receptor activator promote cell proliferation and invasion and predict patient prognosis in human cervical cancer". Oncology Letters 16.4 (2018): 5410-5418.
Chicago
Kim, H. J., Kim, L. K., Lee, S., Park, S. A., Eoh, K. J., Kim, Y. T."Expression levels of the long noncoding RNA steroid receptor activator promote cell proliferation and invasion and predict patient prognosis in human cervical cancer". Oncology Letters 16, no. 4 (2018): 5410-5418. https://doi.org/10.3892/ol.2018.9265
Copy and paste a formatted citation
x
Spandidos Publications style
Kim HJ, Kim LK, Lee SH, Park SA, Eoh KJ and Kim YT: Expression levels of the long noncoding RNA steroid receptor activator promote cell proliferation and invasion and predict patient prognosis in human cervical cancer. Oncol Lett 16: 5410-5418, 2018.
APA
Kim, H.J., Kim, L.K., Lee, S., Park, S.A., Eoh, K.J., & Kim, Y.T. (2018). Expression levels of the long noncoding RNA steroid receptor activator promote cell proliferation and invasion and predict patient prognosis in human cervical cancer. Oncology Letters, 16, 5410-5418. https://doi.org/10.3892/ol.2018.9265
MLA
Kim, H. J., Kim, L. K., Lee, S., Park, S. A., Eoh, K. J., Kim, Y. T."Expression levels of the long noncoding RNA steroid receptor activator promote cell proliferation and invasion and predict patient prognosis in human cervical cancer". Oncology Letters 16.4 (2018): 5410-5418.
Chicago
Kim, H. J., Kim, L. K., Lee, S., Park, S. A., Eoh, K. J., Kim, Y. T."Expression levels of the long noncoding RNA steroid receptor activator promote cell proliferation and invasion and predict patient prognosis in human cervical cancer". Oncology Letters 16, no. 4 (2018): 5410-5418. https://doi.org/10.3892/ol.2018.9265
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