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Article

High expression of S100A12 on intratumoral stroma cells indicates poor prognosis following surgical resection of hepatocellular carcinoma

  • Authors:
    • Hao Cai
    • Bo‑Gen Ye
    • Jian‑Yang Ao
    • Xiao‑Dong Zhu
    • Yuan‑Yuan Zhang
    • Zong‑Tao Chai
    • Cheng‑Hao Wang
    • Hui‑Chuan Sun
  • View Affiliations / Copyright

    Affiliations: Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China
  • Pages: 5398-5404
    |
    Published online on: August 6, 2018
       https://doi.org/10.3892/ol.2018.9270
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Abstract

The S100 protein family is widely involved in the pathological process of various types of cancer. However, the prognostic value of the S100 protein family member S100A12 in hepatocellular carcinoma (HCC) remains unknown. A total of 139 patients undergoing curative surgical resection for HCC from December 2005 to June 2006 were investigated. Immunohistochemistry of S100A12 tissue was performed and expression was classified according to the total positive staining area. Co‑expression of S100A12 with cluster of differentiation (CD)11B, CD15 and CD68 was evaluated using immunofluorescence. Associations between S100A12 expression and preoperative clinicopathological parameters were assessed using a χ2 test or independent sample Student's t‑test. Kaplan‑Meier estimator survival analysis and multivariate Cox's proportional hazard regression model were used to evaluate the prognostic value of S100A12 expression. The expression of S100A12 was restricted exclusively to stroma cells, primarily to myeloid‑derived immune cells, CD15‑positive neutrophils and CD68‑positive macrophages in particular. A total positive staining area of 1,600 µm2 was selected as the threshold between high and low S100A12 expression. There was a statistically significant association between intratumoral S100A12 expression and tumor differentiation (P=0.010). High expression of S100A12 on intratumoral stroma cells was an independent prognostic factor for the overall (P=0.002) and disease‑free survival (P=0.007) rates of HCC following curative surgical resection. No significant association was identified between peritumoral S100A12 expression and HCC prognosis. The results of the present study demonstrated that high expression of S100A12 on intratumoral stroma cells is associated with poor HCC prognosis following curative resection, which may serve as a potential target for an adjuvant therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Cai H, Ye BG, Ao JY, Zhu XD, Zhang YY, Chai ZT, Wang CH and Sun HC: High expression of S100A12 on intratumoral stroma cells indicates poor prognosis following surgical resection of hepatocellular carcinoma. Oncol Lett 16: 5398-5404, 2018.
APA
Cai, H., Ye, B., Ao, J., Zhu, X., Zhang, Y., Chai, Z. ... Sun, H. (2018). High expression of S100A12 on intratumoral stroma cells indicates poor prognosis following surgical resection of hepatocellular carcinoma. Oncology Letters, 16, 5398-5404. https://doi.org/10.3892/ol.2018.9270
MLA
Cai, H., Ye, B., Ao, J., Zhu, X., Zhang, Y., Chai, Z., Wang, C., Sun, H."High expression of S100A12 on intratumoral stroma cells indicates poor prognosis following surgical resection of hepatocellular carcinoma". Oncology Letters 16.4 (2018): 5398-5404.
Chicago
Cai, H., Ye, B., Ao, J., Zhu, X., Zhang, Y., Chai, Z., Wang, C., Sun, H."High expression of S100A12 on intratumoral stroma cells indicates poor prognosis following surgical resection of hepatocellular carcinoma". Oncology Letters 16, no. 4 (2018): 5398-5404. https://doi.org/10.3892/ol.2018.9270
Copy and paste a formatted citation
x
Spandidos Publications style
Cai H, Ye BG, Ao JY, Zhu XD, Zhang YY, Chai ZT, Wang CH and Sun HC: High expression of S100A12 on intratumoral stroma cells indicates poor prognosis following surgical resection of hepatocellular carcinoma. Oncol Lett 16: 5398-5404, 2018.
APA
Cai, H., Ye, B., Ao, J., Zhu, X., Zhang, Y., Chai, Z. ... Sun, H. (2018). High expression of S100A12 on intratumoral stroma cells indicates poor prognosis following surgical resection of hepatocellular carcinoma. Oncology Letters, 16, 5398-5404. https://doi.org/10.3892/ol.2018.9270
MLA
Cai, H., Ye, B., Ao, J., Zhu, X., Zhang, Y., Chai, Z., Wang, C., Sun, H."High expression of S100A12 on intratumoral stroma cells indicates poor prognosis following surgical resection of hepatocellular carcinoma". Oncology Letters 16.4 (2018): 5398-5404.
Chicago
Cai, H., Ye, B., Ao, J., Zhu, X., Zhang, Y., Chai, Z., Wang, C., Sun, H."High expression of S100A12 on intratumoral stroma cells indicates poor prognosis following surgical resection of hepatocellular carcinoma". Oncology Letters 16, no. 4 (2018): 5398-5404. https://doi.org/10.3892/ol.2018.9270
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