Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Correlation between DCE‑MRI radiomics features and Ki‑67 expression in invasive breast cancer

  • Authors:
    • Ma‑Wen Juan
    • Ji Yu
    • Guo‑Xin Peng
    • Liu‑Jun Jun
    • Sun‑Peng Feng
    • Liu‑Pei Fang
  • View Affiliations / Copyright

    Affiliations: Department of Breast Imaging, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, P.R. China
    Copyright: © Juan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5084-5090
    |
    Published online on: August 6, 2018
       https://doi.org/10.3892/ol.2018.9271
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the association between Ki‑67 expression and radiomics features of dynamic contrast‑enhanced magnetic resonance imaging (DCE‑MRI) in patients with invasive breast cancer. A total of 53 cases with low‑Ki‑67 expression (Ki‑67 proliferation index <14%) and 106 cases with high‑Ki‑67 expression (Ki‑67 proliferation index >14%) were investigated. A systematic approach was applied that focused on the automated segmentation of lesions and extraction of radiomics features. For each lesion 5 morphology, 4 gray‑scale histogram and 6 texture features were obtained, and statistical analyzes were performed to assess the differences in these features between the low‑ and high‑Ki‑67 expressions. One morphology metric (area), 3 gray‑scale histogram indexes (standard deviation, skewness and kurtosis) and 3 texture features (contrast, homogeneity and inverse differential moment) demonstrated a significant difference (P<0.05), with low‑Ki‑67 expression lesions tending to be smaller, clearer and heterogeneous when compared with the high‑Ki‑67 expressed cases. These results may provide a noninvasive means to better understand the proliferation of breast cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Fan L, Strasser-Weippl K, Li JJ, St Louis J, Finkelstein DM, Yu KD, Chen WQ, Shao ZM and Goss PE: Breast cancer in China. Lancet Oncol. 15:e279–e289. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Gerdes J, Li L, Schlueter C, Duchrow M, Wohlenberg C, Gerlach C, Stahmer I, Kloth S, Brandt E and Flad HD: Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67. Am J Pathol. 138:867–873. 1991.PubMed/NCBI

3 

de Azambuja E, Cardoso F, de Castro G Jr, Colozza M, Mano MS, Durbecq V, Sotiriou C, Larsimont D, Piccart-Gebhart MJ and Paesmans M: Ki-67 as prognostic marker in early breast cancer: A meta-analysis of published studies involving 12,155 patients. Br J Cancer. 96:1504–1513. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Colozza M, Azambuja E, Cardoso F, Sotiriou C, Larsimont D and Piccart MJ: Proliferative markers as prognostic and predictive tools in early breast cancer: Where are we now? Ann Oncol. 16:1723–1739. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart-Gebhart M, Thürlimann B and Senn HJ: Panel members: Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Ealy Breast Cancer 2013. Ann Oncol. 24:2206–2223. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Brown JR, DiGiovanna MP, Killelea B, Lannin DR and Rimm DL: Quantitative assessment Ki-67 score for prediction of response to neoadjuvant chemotherapy in breast cancer. Lab Invest. 94:98–106. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Diehn M, Nardini C, Wang DS, McGovern S, Jayaraman M, Liang Y, Aldape K, Cha S and Kuo MD: Identification of noninvasive imaging surrogates for brain tumor gene-expression modules. Proc Natl AcadSci USA. 105:5213–5218. 2008. View Article : Google Scholar

8 

Basu S, Kwee TC, Gatenby R, Saboury B, Torigian DA and Alavi A: Evolving role of molecular imaging with PET in detecting and characterizing heterogeneity of cancer tissue at the primary and metastatic sites, a plausible explanation for failed attempts to cure malignant disorders. Eur J Nucl Med Mol Imaging. 38:987–991. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Rutman AM and Kuo MD: Radiogenomics: Creating a link between molecular diagnostics and diagnostic imaging. Eur J Radiol. 70:232–241. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Yip SS and Aerts HJ: Applications and limitations of radiomics. Phys Med Biol. 61:R150–R166. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Lambin P, Rios-Velazquez E, Leijenaar R, Carvalho S, van Stiphout RG, Granton P, Zegers CM, Gillies R, Boellard R, Dekker A and Aerts HJ: Radiomics: Extracting more information from medical images using advanced feature analysis. Eur J Cancer. 48:441–446. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Kumar V, Gu Y, Basu S, Berglund A, Eschrich SA, Schabath MB, Forster K, Aerts HJ, Dekker A, Fenstermacher D, et al: Radiomics: The process and the challenges. Magn Reson Imaging. 30:1234–1248. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Limkin EJ, Sun R, Dercle L, Zacharaki EI, Robert C, Reuzé S, Schernberg A, Paragios N, Deutsch E and Ferté C: Promises and challenges for the implementation of computational medical imaging (radiomics) in oncology. Ann Oncol. 28:1191–1206. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Nie K, Chen JH, Yu HJ, Chu Y, Nalcioglu O and Su MY: Quantitative analysis of lesion morphology and texture features for diagnostic prediction in breast MRI. Acad Radiol. 15:1513–1525. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Kim SG, Freed M, Leite APK, Zhang J, Seuss C and Moy L: Separation of benign and malignant breast lesions using dynamic contrast enhanced MRI in a biopsy cohort. J Magn Reson Imaging. 45:1385–1393. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Chang RF, Chen HH, Chang YC, Huang CS, Chen JH and Lo CM: Quantification of breast tumor heterogeneity for ER status, HER2 status, and TN molecular subtype evaluation on DCE-MRI. Magn Reson Imaging. 34:809–819. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Fan M, Li H, Wang S, Zheng B, Zhang J and Li L: Radiomic analysis reveals DCE-MRI features for prediction of molecular subtypes of breast cancer. PLoS One. 12:e01716832017. View Article : Google Scholar : PubMed/NCBI

18 

Chou SS, Gombos EC, Chikarmane SA, Giess CS and Jayender J: Computer-aided heterogeneity analysis in breast MR imaging assessment of ductal carcinoma in situ: Correlating histologic grade and receptor status. J Magn Reson Imaging. 46:1748–1759. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Agner SC, Rosen MA, Englander S, Tomaszewski JE, Feldman MD, Zhang P, Mies C, Schnall MD and Madabhushi A: Computerized image analysis for identifying triple-negative breast cancers and differentiating them from other molecular subtypes of breast cancer on dynamic contrast-enhanced MR images: A feasibility study. Radiology. 272:91–99. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Sutton EJ, Dashevsky BZ, Oh JH, Veeraraghavan H, Apte AP, Thakur SB, Morris EA and Deasy JO: Breast cancer molecular subtype classifier that incorporates MRI features. J Magn Reson Imaging. 44:122–129. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Lankton S and Tannenbaum A: Localizing region-based active contours. IEEE Trans Image Process. 17:2029–2039. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Rodenacker K and Bengtsson E: A feature set for cytometry on digitized microscopic images. Anal Cell Pathol. 25:1–36. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Haralick R, Shanmugam K and Dinstein I: Texture parameters for image classification. IEEE Trans SMC. 3:610–621. 1973.

24 

Matsubara N, Mukai H, Masumoto M, Sasaki M, Naito Y, Fujii S and Wada N: Survival outcome and reduction rate of Ki-67 between pre- and post-neoadjuvant chemotherapy in breast cancer patients with non-pCR. Breast Cancer Res Treat. 147:95–102. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Li H, Han X, Liu Y, Liu G and Dong G: Ki67 as a predictor of poor prognosis in patients with triple-negative breast cancer. Oncol Lett. 9:149–152. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Juan MW, Yu J, Peng GX, Jun LJ, Feng SP and Fang LP: Correlation between DCE‑MRI radiomics features and Ki‑67 expression in invasive breast cancer. Oncol Lett 16: 5084-5090, 2018.
APA
Juan, M., Yu, J., Peng, G., Jun, L., Feng, S., & Fang, L. (2018). Correlation between DCE‑MRI radiomics features and Ki‑67 expression in invasive breast cancer. Oncology Letters, 16, 5084-5090. https://doi.org/10.3892/ol.2018.9271
MLA
Juan, M., Yu, J., Peng, G., Jun, L., Feng, S., Fang, L."Correlation between DCE‑MRI radiomics features and Ki‑67 expression in invasive breast cancer". Oncology Letters 16.4 (2018): 5084-5090.
Chicago
Juan, M., Yu, J., Peng, G., Jun, L., Feng, S., Fang, L."Correlation between DCE‑MRI radiomics features and Ki‑67 expression in invasive breast cancer". Oncology Letters 16, no. 4 (2018): 5084-5090. https://doi.org/10.3892/ol.2018.9271
Copy and paste a formatted citation
x
Spandidos Publications style
Juan MW, Yu J, Peng GX, Jun LJ, Feng SP and Fang LP: Correlation between DCE‑MRI radiomics features and Ki‑67 expression in invasive breast cancer. Oncol Lett 16: 5084-5090, 2018.
APA
Juan, M., Yu, J., Peng, G., Jun, L., Feng, S., & Fang, L. (2018). Correlation between DCE‑MRI radiomics features and Ki‑67 expression in invasive breast cancer. Oncology Letters, 16, 5084-5090. https://doi.org/10.3892/ol.2018.9271
MLA
Juan, M., Yu, J., Peng, G., Jun, L., Feng, S., Fang, L."Correlation between DCE‑MRI radiomics features and Ki‑67 expression in invasive breast cancer". Oncology Letters 16.4 (2018): 5084-5090.
Chicago
Juan, M., Yu, J., Peng, G., Jun, L., Feng, S., Fang, L."Correlation between DCE‑MRI radiomics features and Ki‑67 expression in invasive breast cancer". Oncology Letters 16, no. 4 (2018): 5084-5090. https://doi.org/10.3892/ol.2018.9271
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team