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Article

miR‑27a in serum acts as biomarker for prostate cancer detection and promotes cell proliferation by targeting Sprouty2

  • Authors:
    • Weiyin Gao
    • Zhengdong Hong
    • Hongwei Huang
    • Anyi Zhu
    • Shuangquan Lin
    • Cheng Cheng
    • Xiao Zhang
    • Gaode Zou
    • Zimin Shi
  • View Affiliations / Copyright

    Affiliations: Department of Urology Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330001, P.R. China
  • Pages: 5291-5298
    |
    Published online on: August 7, 2018
       https://doi.org/10.3892/ol.2018.9274
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Abstract

Prostate cancer (PCa) exhibits a high incidence among men, but there is no effective and non‑invasive biomarker for the diagnosis of PCa, and the pathogenesis of PCa remains unclear. The present study identified that miR‑27a was significantly overexpressed in the tumor tissues and sera of patients with PCa. In addition, high serum levels of miR‑27a were correlated with poor survival in patients with PCa. Receiver‑operating characteristic curves analysis demonstrated that the serum levels of miR‑27a exhibited a high area under the curve value. Furthermore, miR‑27a mimics or inhibitors significantly promoted or repressed the proliferation of PCa cells, respectively. In addition, it was identified that the expression of Sprouty2 (SPRY2) was inversely correlated with the expression of miR‑27a in PCa tissues. The knockdown or overexpression of SPRY2 promoted or suppressed the proliferation of PCa cells, respectively, and the overexpression of SPRY2 inhibited the increased proliferation and cell cycle distribution of PCa cells mediated by miR‑27a mimics. Taken together, these data indicated that the serum levels of miR‑27a may be a novel and non‑invasive biomarker for the diagnosis and prognosis of patients with PCa, and miR‑27a/SPRY2 may be a therapeutic target for the treatment of PCa.
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Copy and paste a formatted citation
Spandidos Publications style
Gao W, Hong Z, Huang H, Zhu A, Lin S, Cheng C, Zhang X, Zou G and Shi Z: miR‑27a in serum acts as biomarker for prostate cancer detection and promotes cell proliferation by targeting Sprouty2. Oncol Lett 16: 5291-5298, 2018.
APA
Gao, W., Hong, Z., Huang, H., Zhu, A., Lin, S., Cheng, C. ... Shi, Z. (2018). miR‑27a in serum acts as biomarker for prostate cancer detection and promotes cell proliferation by targeting Sprouty2. Oncology Letters, 16, 5291-5298. https://doi.org/10.3892/ol.2018.9274
MLA
Gao, W., Hong, Z., Huang, H., Zhu, A., Lin, S., Cheng, C., Zhang, X., Zou, G., Shi, Z."miR‑27a in serum acts as biomarker for prostate cancer detection and promotes cell proliferation by targeting Sprouty2". Oncology Letters 16.4 (2018): 5291-5298.
Chicago
Gao, W., Hong, Z., Huang, H., Zhu, A., Lin, S., Cheng, C., Zhang, X., Zou, G., Shi, Z."miR‑27a in serum acts as biomarker for prostate cancer detection and promotes cell proliferation by targeting Sprouty2". Oncology Letters 16, no. 4 (2018): 5291-5298. https://doi.org/10.3892/ol.2018.9274
Copy and paste a formatted citation
x
Spandidos Publications style
Gao W, Hong Z, Huang H, Zhu A, Lin S, Cheng C, Zhang X, Zou G and Shi Z: miR‑27a in serum acts as biomarker for prostate cancer detection and promotes cell proliferation by targeting Sprouty2. Oncol Lett 16: 5291-5298, 2018.
APA
Gao, W., Hong, Z., Huang, H., Zhu, A., Lin, S., Cheng, C. ... Shi, Z. (2018). miR‑27a in serum acts as biomarker for prostate cancer detection and promotes cell proliferation by targeting Sprouty2. Oncology Letters, 16, 5291-5298. https://doi.org/10.3892/ol.2018.9274
MLA
Gao, W., Hong, Z., Huang, H., Zhu, A., Lin, S., Cheng, C., Zhang, X., Zou, G., Shi, Z."miR‑27a in serum acts as biomarker for prostate cancer detection and promotes cell proliferation by targeting Sprouty2". Oncology Letters 16.4 (2018): 5291-5298.
Chicago
Gao, W., Hong, Z., Huang, H., Zhu, A., Lin, S., Cheng, C., Zhang, X., Zou, G., Shi, Z."miR‑27a in serum acts as biomarker for prostate cancer detection and promotes cell proliferation by targeting Sprouty2". Oncology Letters 16, no. 4 (2018): 5291-5298. https://doi.org/10.3892/ol.2018.9274
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