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Growth inhibition and chemo‑radiosensitization of esophageal squamous cell carcinoma by survivin‑shRNA lentivirus transfection

  • Authors:
    • Changlin Zhou
    • Lin Zhang
    • Peng Xu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Jining First People's Hospital, Jining, Shandong 272011, P.R. China, Department of Thoracic Surgery, Ji'nan Central Hospital Affiliated to Shandong University, Ji'nan, Shandong 250013, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4813-4820
    |
    Published online on: August 8, 2018
       https://doi.org/10.3892/ol.2018.9280
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Abstract

Esophageal cancer is one of the most common types of cancer worldwide, and it has a poor prognosis. Chemo‑radiotherapy resistance and cancer relapse are among the most difficult issues in its treatment. Identifying the underlying molecular mechanisms is critical for developing novel therapies. Survivin has been previously suggested to be overexpressed in esophageal cancer cells. The present study identified that down‑regulation of survivin sensitized esophageal cancer cells to chemo‑radiotherapy. Consistent with previous studies, the present study indicated that survivin was overexpressed in 4 esophageal squamous carcinoma cell lines. Short hairpin RNA delivered by lentivirus successfully knocked down survivin in these cancer cell lines. Consequently, down‑regulation of survivin impaired their colony‑forming, migratory and invasive capabilities, while the overexpression of survivin in normal human esophagus epithelial cells improved their resistance to cisplatin, paclitaxel and radiation. Survivin knockdown induced apoptosis in esophageal cancer KYSE‑150 and ECA‑109 cell lines when exposed to the aforementioned chemo‑radiotherapy treatments. These results indicate that survivin expression sustains growth in esophageal cancer cells, and confers resistance to chemo‑radiotherapy. Targeted survivin ablation may be a promising strategy against esophageal tumor relapse and chemo‑radioresistance.
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1 

Zhang Y: Epidemiology of esophageal cancer. World J Gastroenterol. 19:5598–5606. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Napier KJ, Scheerer M and Misra S: Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities. World J Gastrointest Oncol. 6:112–120. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Lin Y, Totsuka Y, He Y, Kikuchi S, Qiao Y, Ueda J, Wei W, Inoue M and Tanaka H: Epidemiology of esophageal cancer in Japan and China. J Epidemiol. 23:233–242. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Hiripi E, Jansen L, Gondos A, Hiripi E, Jansen L, Gondos A, Emrich K, Holleczek B, Katalinic A, Luttmann S, et al: Survival of stomach and esophagus cancer patients in Germany in the early 21st century. Acta Oncol. 51:906–914. 2012. View Article : Google Scholar : PubMed/NCBI

5 

van Hagen P, Hulshof MC, van Lanschot JJ, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BP, Richel DJ, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, et al: Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med. 366:2074–2084. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Gebski V, Burmeister B, Smithers BM, Foo K, Zalcberg J and Simes J: Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: A meta-analysis. Lancet Oncol. 8:226–234. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Ando N, Kato H, Igaki H, Shinoda M, Ozawa S, Shimizu H, Nakamura T, Yabusaki H, Aoyama N, Kurita A, et al: A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907). Ann Surg Oncol. 19:68–74. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Sgourakis G, Gockel I, Karaliotas C, Moehler M, Schimanski CC, Schmidberger H and Junginger T: Survival after chemotherapy and/or radiotherapy versus self-expanding metal stent insertion in the setting of inoperable esophageal cancer: A case-control study. BMC Cancer. 12:702012. View Article : Google Scholar : PubMed/NCBI

9 

Liao Z, Cox JD and Komaki R: Radiochemotherapy of esophageal cancer. J Thorac Oncol. 2:553–568. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Smit JK, Faber H, Niemantsverdriet M, Baanstra M, Bussink J, Hollema H, van Os RP, Plukker JT and Coppes RP: Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markers. Radiother Oncol. 107:434–441. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Hummel R, Sie C, Watson DI, Wang T, Ansar A, Michael MZ, van der Hoek M, Haier J and Hussey DJ: MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines. World J Gastroenterol. 20:14904–14912. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Ferrario A, Rucker N, Wong S, Luna M and Gomer CJ: Survivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response. Cancer Res. 67:4989–4995. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Eckelman BP, Salvesen GS and Scott FL: Human inhibitor of apoptosis proteins: Why XIAP is the black sheep of the family. EMBO Rep. 7:988–994. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Suzuki Y, Nakabayashi Y and Takahashi R: Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc Natl Acad Sci USA. 98:8662–8667. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Rodel F, Sprenger T, Kaina B, Liersch T, Rödel C, Fulda S and Hehlgans S: Survivin as a prognostic/predictive marker and molecular target in cancer therapy. Curr Med Chem. 19:3679–3688. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Mobahat M, Narendran A and Riabowol K: Survivin as a preferential target for cancer therapy. Int J Mol Sci. 15:2494–2516. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Kato J, Kuwabara Y, Mitani M, Shinoda N, Sato A, Toyama T, Mitsui A, Nishiwaki T, Moriyama S, Kudo J and Fujii Y: Expression of survivin in esophageal cancer: Correlation with the prognosis and response to chemotherapy. Int J Cancer. 95:92–95. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Xia H, Chen S, Huang H and Ma H: Survivin over-expression is correlated with a poor prognosis in esophageal cancer patients. Clin Chim Acta. 446:82–85. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Rosato A, Pivetta M, Parenti A, Iaderosa GA, Zoso A, Milan G, Mandruzzato S, Del Bianco P, Ruol A, Zaninotto G and Zanovello P: Survivin in esophageal cancer: An accurate prognostic marker for squamous cell carcinoma but not adenocarcinoma. Int J Cancer. 119:1717–1722. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Wang Y, Zhu H, Quan L, Zhou C, Bai J, Zhang G, Zhan Q and Xu N: Downregulation of survivin by RNAi inhibits the growth of esophageal carcinoma cells. Cancer Biol Ther. 4:974–978. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Zeng W, Li H, Chen Y, Lv H, Liu L, Ran J, Sun X, Bieerkehazhi S, Liu Y, Li X, et al: Survivin activates NF-κB p65 via the IKKβ promoter in esophageal squamous cell carcinoma. Mol Med Rep. 13:1869–1880. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, et al: A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell. 124:1283–1298. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Liang CC, Park AY and Guan JL: In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc. 2:329–333. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Khan Z, Khan AA, Prasad GB, Khan N, Tiwari RP and Bisen PS: Growth inhibition and chemo-radiosensitization of head and neck squamous cell carcinoma (HNSCC) by survivin-siRNA lentivirus. Radiother Oncol. 118:359–368. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Plescia J, Salz W, Xia F, Pennati M, Zaffaroni N, Daidone MG, Meli M, Dohi T, Fortugno P, Nefedova Y, et al: Rational design of shepherdin, a novel anticancer agent. Cancer Cell. 7:457–468. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Minoda M, Kawamoto T, Ueha T, Kamata E, Morishita M, Harada R, Toda M, Onishi Y, Hara H, Kurosaka M and Akisue T: Antitumor effect of YM155, a novel small-molecule survivin suppressant, via mitochondrial apoptosis in human MFH/UPS. Int J Oncol. 47:891–899. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Nakahara T, Kita A, Yamanaka K, Mori M, Amino N, Takeuchi M, Tominaga F, Hatakeyama S, Kinoyama I, Matsuhisa A, et al: YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Res. 67:8014–8021. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Kelly RJ, Thomas A, Rajan A, Chun G, Lopez-Chavez A, Szabo E, Spencer S, Carter CA, Guha U, Khozin S, et al: A phase I/II study of sepantronium bromide (YM155, survivin suppressor) with paclitaxel and carboplatin in patients with advanced non-small-cell lung cancer. Ann Oncol. 24:2601–2606. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Clemens MR, Gladkov OA, Gartner E, Vladimirov V, Crown J, Steinberg J, Jie F and Keating A: Phase II, multicenter, open-label, randomized study of YM155 plus docetaxel as first-line treatment in patients with HER2-negative metastatic breast cancer. Breast Cancer Res Treat. 149:171–179. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Ma WH, Liu YC, Xue ML, Zheng Z and Ge YL: Downregulation of survivin expression exerts antitumoral effects on mouse breast cancer cells in vitro and in vivo. Oncol Lett. 11:159–167. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Wang H and Ye YF: Effect of survivin siRNA on biological behaviour of breast cancer MCF7 cells. Asian Pac J Trop Med. 8:225–228. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Kogo R, How C, Chaudary N, Bruce J, Shi W, Hill RP, Zahedi P, Yip KW and Liu FF: The microRNA-218~Survivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer. Oncotarget. 6:1090–1100. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Wang J, Li Z, Lin Z, Zhao B, Wang Y, Peng R, Wang M, Lu C, Shi G and Shen Y: 17-DMCHAG, a new geldanamycin derivative, inhibits prostate cancer cells through Hsp90 inhibition and survivin downregulation. Cancer Lett. 362:83–96. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Carew JS, Espitia CM, Zhao W, Mita MM, Mita AC and Nawrocki ST: Targeting survivin inhibits renal cell carcinoma progression and enhances the activity of temsirolimus. Mol Cancer Ther. 14:1404–1413. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Tsubaki M, Takeda T, Ogawa N, Sakamoto K, Shimaoka H, Fujita A, Itoh T, Imano M, Ishizaka T, Satou T and Nishida S: Overexpression of survivin via activation of ERK1/2, Akt, and NF-κB plays a central role in vincristine resistance in multiple myeloma cells. Leuk Res. 39:445–452. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Shen X, Zheng JY, Shi H, Zhang Z and Wang WZ: Survivin knockdown enhances gastric cancer cell sensitivity to radiation and chemotherapy in vitro and in nude mice. Am J Med Sci. 344:52–58. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Morrison DJ, Hogan LE, Condos G, Bhatla T, Germino N, Moskowitz NP, Lee L, Bhojwani D, Horton TM, Belitskaya-Levy I, et al: Endogenous knockdown of survivin improves chemotherapeutic response in ALL models. Leukemia. 26:271–279. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Kunze D, Erdmann K, Froehner M, Wirth MP and Fuessel S: Enhanced inhibition of bladder cancer cell growth by simultaneous knockdown of antiapoptotic Bcl-xL and survivin in combination with chemotherapy. Int J Mol Sci. 14:12297–12312. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Cui M, Au JL, Wientjes MG, O'Donnell MA, Loughlin KR and Lu Z: Intravenous siRNA silencing of survivin enhances activity of mitomycin C in human bladder RT4 ×enografts. J Urol. 194:230–237. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Faversani A, Vaira V, Moro GP, Tosi D, Lopergolo A, Schultz DC, Rivadeneira D, Altieri DC and Bosari S: Survivin family proteins as novel molecular determinants of doxorubicin resistance in organotypic human breast tumors. Breast Cancer Res. 16:R552014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou C, Zhang L and Xu P: Growth inhibition and chemo‑radiosensitization of esophageal squamous cell carcinoma by survivin‑shRNA lentivirus transfection. Oncol Lett 16: 4813-4820, 2018.
APA
Zhou, C., Zhang, L., & Xu, P. (2018). Growth inhibition and chemo‑radiosensitization of esophageal squamous cell carcinoma by survivin‑shRNA lentivirus transfection. Oncology Letters, 16, 4813-4820. https://doi.org/10.3892/ol.2018.9280
MLA
Zhou, C., Zhang, L., Xu, P."Growth inhibition and chemo‑radiosensitization of esophageal squamous cell carcinoma by survivin‑shRNA lentivirus transfection". Oncology Letters 16.4 (2018): 4813-4820.
Chicago
Zhou, C., Zhang, L., Xu, P."Growth inhibition and chemo‑radiosensitization of esophageal squamous cell carcinoma by survivin‑shRNA lentivirus transfection". Oncology Letters 16, no. 4 (2018): 4813-4820. https://doi.org/10.3892/ol.2018.9280
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou C, Zhang L and Xu P: Growth inhibition and chemo‑radiosensitization of esophageal squamous cell carcinoma by survivin‑shRNA lentivirus transfection. Oncol Lett 16: 4813-4820, 2018.
APA
Zhou, C., Zhang, L., & Xu, P. (2018). Growth inhibition and chemo‑radiosensitization of esophageal squamous cell carcinoma by survivin‑shRNA lentivirus transfection. Oncology Letters, 16, 4813-4820. https://doi.org/10.3892/ol.2018.9280
MLA
Zhou, C., Zhang, L., Xu, P."Growth inhibition and chemo‑radiosensitization of esophageal squamous cell carcinoma by survivin‑shRNA lentivirus transfection". Oncology Letters 16.4 (2018): 4813-4820.
Chicago
Zhou, C., Zhang, L., Xu, P."Growth inhibition and chemo‑radiosensitization of esophageal squamous cell carcinoma by survivin‑shRNA lentivirus transfection". Oncology Letters 16, no. 4 (2018): 4813-4820. https://doi.org/10.3892/ol.2018.9280
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