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Article Open Access

Preoperative platelet‑lymphocyte ratio is an independent prognostic factor in ampullary carcinoma following pancreaticoduodenectomy

  • Authors:
    • Wenqin Wang
    • Wei Liu
    • Ning Zhang
    • Xiaodong He
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100730, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4879-4888
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    Published online on: August 8, 2018
       https://doi.org/10.3892/ol.2018.9285
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Abstract

The objective of the present study was to evaluate whether preoperative platelet‑lymphocyte ratio (PLR) and neutrophil‑lymphocyte ratio (NLR) could predict the prognosis for curative resected ampullary carcinoma. A total of 94 patients were retrospectively included over a 6‑year period in which consecutive cases underwent pancreaticoduodenectomy for ampullary malignancy. Preoperative blood results were available in the 94 cases of resected ampullary carcinoma. Preoperative PLR and NLR cut‑off values of 226.8 and 2.58 were determined to represent the optimal cut‑off values in the cases for survival analysis. PLR remained a significant independent predictor of survival in multivariate analysis (Cox, P<0.001) in addition to tumor differentiation (P<0.001), nodal status (P<0.001) and stage (P<0.001). While NLR failed to serve as a prognostic factor in univariate (P=0.0637) and multivariate (P=0.164) survival analysis. Furthermore, the nodal involvement rate was higher in high PLR group (74.2 vs. 19.05%, P<0.001). Preoperative PLR and NLR merit further evaluation as a prognostic index in curative resected ampullary carcinoma. Additionally, it is a candidate predictor for the lymph node metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Wang W, Liu W, Zhang N and He X: Preoperative platelet‑lymphocyte ratio is an independent prognostic factor in ampullary carcinoma following pancreaticoduodenectomy. Oncol Lett 16: 4879-4888, 2018.
APA
Wang, W., Liu, W., Zhang, N., & He, X. (2018). Preoperative platelet‑lymphocyte ratio is an independent prognostic factor in ampullary carcinoma following pancreaticoduodenectomy. Oncology Letters, 16, 4879-4888. https://doi.org/10.3892/ol.2018.9285
MLA
Wang, W., Liu, W., Zhang, N., He, X."Preoperative platelet‑lymphocyte ratio is an independent prognostic factor in ampullary carcinoma following pancreaticoduodenectomy". Oncology Letters 16.4 (2018): 4879-4888.
Chicago
Wang, W., Liu, W., Zhang, N., He, X."Preoperative platelet‑lymphocyte ratio is an independent prognostic factor in ampullary carcinoma following pancreaticoduodenectomy". Oncology Letters 16, no. 4 (2018): 4879-4888. https://doi.org/10.3892/ol.2018.9285
Copy and paste a formatted citation
x
Spandidos Publications style
Wang W, Liu W, Zhang N and He X: Preoperative platelet‑lymphocyte ratio is an independent prognostic factor in ampullary carcinoma following pancreaticoduodenectomy. Oncol Lett 16: 4879-4888, 2018.
APA
Wang, W., Liu, W., Zhang, N., & He, X. (2018). Preoperative platelet‑lymphocyte ratio is an independent prognostic factor in ampullary carcinoma following pancreaticoduodenectomy. Oncology Letters, 16, 4879-4888. https://doi.org/10.3892/ol.2018.9285
MLA
Wang, W., Liu, W., Zhang, N., He, X."Preoperative platelet‑lymphocyte ratio is an independent prognostic factor in ampullary carcinoma following pancreaticoduodenectomy". Oncology Letters 16.4 (2018): 4879-4888.
Chicago
Wang, W., Liu, W., Zhang, N., He, X."Preoperative platelet‑lymphocyte ratio is an independent prognostic factor in ampullary carcinoma following pancreaticoduodenectomy". Oncology Letters 16, no. 4 (2018): 4879-4888. https://doi.org/10.3892/ol.2018.9285
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