Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Plasma ω‑3 and ω‑6 fatty acids in thyroid diseases

  • Authors:
    • Xiang Li
    • Hui Li
    • Jing Zhao
    • Qi Dai
    • Chaoran Huang
    • Langping Jin
    • Fan Yang
    • Fuxue Chen
    • Ouchen Wang
    • Ying Gao
  • View Affiliations / Copyright

    Affiliations: School of Life Sciences, Shanghai University, Shanghai 200444, P.R. China, Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, P.R. China, Chinese Academy of Sciences Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P.R. China, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China, Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
  • Pages: 5433-5440
    |
    Published online on: August 9, 2018
       https://doi.org/10.3892/ol.2018.9288
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The incidences of nodular goiter (NG), thyroid adenoma (TA), and thyroid cancer (TC) are increasing rapidly; however, the etiologies of these diseases remain unclear. The present study aimed to evaluate the differences in plasma fatty acids among these three thyroid diseases to facilitate etiological research. Four ω‑3 and seven ω‑6 polyunsaturated fatty acids were measured from 97 TC, 14 TA and 11 NG patient plasma samples with gas chromatography‑flame ionization detector. Fatty acids levels were expressed as the percentage of each fatty acid out of the total fatty acids evaluated. The present study identified that the level of 22:6n‑3 [median, interquartile range (IQR)] was significantly increased in TA (5.2%, 4.3‑6.4%) compared with NG (3.6%, 3.1‑4.6%) and TC patients (4.2%, 3.2‑4.8%). Though not statistically significant, the levels of 20:5n‑3 and 22:5n‑3 demonstrated a similar pattern. The level of 22:4n‑6 expressed (median, IQR) was significantly increased in NG patients (0.21%, 0.18‑0.26%) compared with TA (0.16%, 0.15‑0.18%) and TC (0.17%, 0.14‑0.22%) patients. Furthermore the fatty acids 18:3n‑6, 20:2n‑6, 20:3n‑6, 20:4:6, and 22:5n‑6 demonstrated a similar but statistically insignificant pattern. This suggests that different fatty acids exhibit various etiological roles in NG, TA and TC and warrant further study.
View Figures

Figure 1

View References

1 

Davies L, Ouellette M, Hunter M and Welch HG: The increasing incidence of small thyroid cancers: Where are the cases coming from? Laryngoscope. 120:2446–2451. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Schneider DF and Chen H: New developments in the diagnosis and treatment of thyroid cancer. CA Cancer J Clin. 63:374–394. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Burman KD and Wartofsky L: Clinical Practice. Thyroid nodules. N Engl J Med. 373:2347–2356. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Hedinger C, Williams ED and Sobin LH: The WHO histological classification of thyroid tumors: A commentary on the second edition. Cancer. 63:908–911. 1989. View Article : Google Scholar : PubMed/NCBI

7 

La Vecchia C, Malvezzi M, Bosetti C, Garavello W, Bertuccio P, Levi F and Negri E: Thyroid cancer mortality and incidence: A global overview. Int J Cancer. 136:2187–2195. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Xing M: Molecular pathogenesis and mechanisms of thyroid cancer. Nat Rev Cancer. 13:184–199. 2013. View Article : Google Scholar : PubMed/NCBI

9 

American Thyroid Association Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, ; Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, et al: Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 19:1167–1214. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Crippa S, Mazzucchelli L, Cibas ES and Ali SZ: The Bethesda System for reporting thyroid fine-needle aspiration specimens. Am J Clin Pathol. 134:343–345. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Zablotska LB, Nadyrov EA, Polyanskaya ON, McConnell RJ, O'Kane P, Lubin J, Hatch M, Little MP, Brenner AV, Veyalkin IV, et al: Risk of thyroid follicular adenoma among children and adolescents in Belarus exposed to iodine-131 after the Chornobyl accident. Am J Epidemiol. 182:781–790. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Dutta-Roy AK: Cellular uptake of long-chain fatty acids: Role of membrane-associated fatty-acid-binding/transport proteins. Cell Mol Life Sci. 57:1360–1372. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Nickerson JG, Alkhateeb H, Benton CR, Lally J, Nickerson J, Han XX, Wilson MH, Jain SS, Snook LA, Glatz JF, et al: Greater transport efficiencies of the membrane fatty acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1 and differential effects on fatty acid esterification and oxidation in rat skeletal muscle. J Biol Chem. 284:16522–16530. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Santos CR and Schulze A: Lipid metabolism in cancer. FEBS J. 279:2610–2623. 2012. View Article : Google Scholar : PubMed/NCBI

15 

de Souza RJ, Mente A, Maroleanu A, Cozma AI, Ha V, Kishibe T, Uleryk E, Budylowski P, Schünemann H, Beyene J and Anand SS: Intake of saturated and trans unsaturated fatty acids and risk of all-cause mortality, cardiovascular disease, and type 2 diabetes: Systematic review and meta-analysis of observational studies. BMJ. 351:h39782015. View Article : Google Scholar : PubMed/NCBI

16 

Lagrou A, Dierick W, Christophe A and Verdonk G: Lipid composition of normal and hypertrophic bovine thyroids. Lipids. 9:870–875. 1974. View Article : Google Scholar : PubMed/NCBI

17 

Butte NF, Puyau MR, Vohra FA, Adolph AL, Mehta NR and Zakeri I: Body size, body composition, and metabolic profile explain higher energy expenditure in overweight children. J Nutr. 137:2660–2667. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Berg JP, Glattre E, Haldorsen T, Høstmark AT, Bay IG, Johansen AF and Jellum E: Longchain serum fatty acids and risk of thyroid cancer: A population-based case-control study in Norway. Cancer Causes Control. 5:433–439. 1994. View Article : Google Scholar : PubMed/NCBI

19 

Zhang Y, Qiu L, He C, Wang Y, Liu Y, Zhang D and Li Z: Serum unsaturated free fatty acids: A potential biomarker panel for differentiating benign thyroid diseases from thyroid cancer. J Cancer. 6:1276–1281. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Yao Z, Yin P, Su D, Peng Z, Zhou L, Ma L, Guo W, Ma L, Xu G, Shi J and Jiao B: Serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter. Mol Biosyst. 7:2608–2614. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Kim KM, Jung BH, Lho DS, Chung WY, Paeng KJ and Chung BC: Alteration of urinary profiles of endogenous steroids and polyunsaturated fatty acids in thyroid cancer. Cancer Lett. 202:173–179. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Leng J, Guan Q, Sun T, Wu Y, Cao Y and Guo Y: Application of isotope-based carboxy group derivatization in LC-MS/MS analysis of tissue free-fatty acids for thyroid carcinoma. J Pharm Biomed Anal. 84:256–262. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Guo S, Wang Y, Zhou D and Li Z: Significantly increased monounsaturated lipids relative to polyunsaturated lipids in six types of cancer microenvironment are observed by mass spectrometry imaging. Sci Rep. 4:59592014. View Article : Google Scholar : PubMed/NCBI

24 

Chinese Society of Endocrinology, Chinese Medical Association, . China Thyroid Disease Diagnosis and Treatment Guidelines. Zhonghua Nei Ke Za Zhi. 47:867–868. 2008.(In Chinese).

25 

Davies L and Welch HG: Current thyroid cancer trends in the United States. JAMA Otolaryngol Head Neck Surg. 140:317–322. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Hoang JK, Nguyen XV and Davies L: Overdiagnosis of thyroid cancer: Answers to five key questions. Acad Radiol. 22:1024–1029. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Kolonel LN, Hankin JH, Wilkens LR, Fukunaga FH and Hinds MW: An epidemiologic study of thyroid cancer in Hawaii. Cancer Causes Control. 1:223–234. 1990. View Article : Google Scholar : PubMed/NCBI

28 

Glattre E, Haldorsen T, Berg JP, Stensvold I and Solvoll K: Norwegian case-control study testing the hypothesis that seafood increases the risk of thyroid cancer. Cancer Causes Control. 4:11–16. 1993. View Article : Google Scholar : PubMed/NCBI

29 

Horn-Ross PL, Morris JS, Lee M, West DW, Whittemore AS, McDougall IR, Nowels K, Stewart SL, Spate VL, Shiau AC and Krone MR: Iodine and thyroid cancer risk among women in a multiethnic population: the Bay Area Thyroid Cancer Study. Cancer Epidemiol Biomarkers Prev. 10:979–985. 2001.PubMed/NCBI

30 

Wang Yilong: Study of Wenzhou food culture. Zhejiang Ocean University; 2014, (In Chinese).

31 

Uddin S, Siraj AK, Al-Rasheed M, Ahmed M, Bu R, Myers JN, Al-Nuaim A, Al-Sobhi S, Al-Dayel F, Bavi P, et al: Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers. J Clin Endocrinol Metab. 93:4088–4097. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Calder PC: Polyunsaturated fatty acids, inflammation, and immunity. Lipids. 36:1007–1024. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Hegedus L: Clinical practice. The thyroid nodule. N Engl J Med. 351:1764–1771. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Bjoro T, Holmen J, Kruger O, Midthjell K, Hunstad K, Schreiner T, Sandnes L and Brochmann H: Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase antibodies in a large, unselected population. The Health Study of Nord-Trondelag (HUNT). Eur J Endocrinol. 143:639–647. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Prummel MF and Wiersinga WM: Thyroid peroxidase autoantibodies in euthyroid subjects. Best Pract Res Clin Endocrinol Metab. 19:1–15. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Fiore E and Vitti P: Serum TSH and risk of papillary thyroid cancer in nodular thyroid disease. J Clin Endocrinol Metab. 97:1134–1145. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Xu Y, Zheng X, Qiu Y, Jia W, Wang J and Yin S: Distinct metabolomic profiles of papillary thyroid carcinoma and benign thyroid adenoma. J Proteome Res. 14:3315–3321. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Chen JH, Perry CJ, Tsui YC, Staron MM, Parish IA, Dominguez CX, Rosenberg DW and Kaech SM: Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection. Nat Med. 21:327–334. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Nikiforova MN, Lynch RA, Biddinger PW, Alexander EK, Dorn GW III, Tallini G, Kroll TG and Nikiforov YE: RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: Evidence for distinct molecular pathways in thyroid follicular carcinoma. J Clin Endocrinol Metab. 88:2318–2326. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Fugazzola L, Puxeddu E, Avenia N, Romei C, Cirello V, Cavaliere A, Faviana P, Mannavola D, Moretti S, Rossi S, et al: Correlation between B-RAFV600E mutation and clinico-pathologic parameters in papillary thyroid carcinoma: Data from a multicentric Italian study and review of the literature. Endocr Relat Cancer. 13:455–464. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li X, Li H, Zhao J, Dai Q, Huang C, Jin L, Yang F, Chen F, Wang O, Gao Y, Gao Y, et al: Plasma ω‑3 and ω‑6 fatty acids in thyroid diseases. Oncol Lett 16: 5433-5440, 2018.
APA
Li, X., Li, H., Zhao, J., Dai, Q., Huang, C., Jin, L. ... Gao, Y. (2018). Plasma ω‑3 and ω‑6 fatty acids in thyroid diseases. Oncology Letters, 16, 5433-5440. https://doi.org/10.3892/ol.2018.9288
MLA
Li, X., Li, H., Zhao, J., Dai, Q., Huang, C., Jin, L., Yang, F., Chen, F., Wang, O., Gao, Y."Plasma ω‑3 and ω‑6 fatty acids in thyroid diseases". Oncology Letters 16.4 (2018): 5433-5440.
Chicago
Li, X., Li, H., Zhao, J., Dai, Q., Huang, C., Jin, L., Yang, F., Chen, F., Wang, O., Gao, Y."Plasma ω‑3 and ω‑6 fatty acids in thyroid diseases". Oncology Letters 16, no. 4 (2018): 5433-5440. https://doi.org/10.3892/ol.2018.9288
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Li H, Zhao J, Dai Q, Huang C, Jin L, Yang F, Chen F, Wang O, Gao Y, Gao Y, et al: Plasma ω‑3 and ω‑6 fatty acids in thyroid diseases. Oncol Lett 16: 5433-5440, 2018.
APA
Li, X., Li, H., Zhao, J., Dai, Q., Huang, C., Jin, L. ... Gao, Y. (2018). Plasma ω‑3 and ω‑6 fatty acids in thyroid diseases. Oncology Letters, 16, 5433-5440. https://doi.org/10.3892/ol.2018.9288
MLA
Li, X., Li, H., Zhao, J., Dai, Q., Huang, C., Jin, L., Yang, F., Chen, F., Wang, O., Gao, Y."Plasma ω‑3 and ω‑6 fatty acids in thyroid diseases". Oncology Letters 16.4 (2018): 5433-5440.
Chicago
Li, X., Li, H., Zhao, J., Dai, Q., Huang, C., Jin, L., Yang, F., Chen, F., Wang, O., Gao, Y."Plasma ω‑3 and ω‑6 fatty acids in thyroid diseases". Oncology Letters 16, no. 4 (2018): 5433-5440. https://doi.org/10.3892/ol.2018.9288
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team