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Photodynamic therapy reduces the inhibitory effect of osteosarcoma cells on dendritic cells by upregulating HSP70

  • Authors:
    • Fan Zhang
    • Yanjie Zhu
    • Guoxin Fan
    • Shuo Hu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5034-5040
    |
    Published online on: August 17, 2018
       https://doi.org/10.3892/ol.2018.9322
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Abstract

Osteosarcoma is the most common primary bone tumor and predominantly affects children and adolescents. The prognosis for patients with osteosarcoma is poor. Therefore, the development of novel treatments for osteosarcoma is required. Photodynamic therapy (PDT) is a disease site‑specific treatment that utilizes a photosensitizing agent along with light to kill cancer cells. This agent only works following activation by certain wavelengths of light. After the agent is absorbed by the cancer cells, light is then applied to the area to be treated. The light causes the drug to react with oxygen, which produces radical and reactive oxygen species that kill the cells. However, the immune reaction that occurs following PDT remains unknown. The present study demonstrated that the necrosis of osteosarcoma cells inhibited the function of dendritic cells. However, treatment of osteosarcoma cells with PDT restored the function of dendritic cells by upregulating heat shock protein 70. Taken together, the results of the present study provided insight into the subsequent molecular reaction following PDT treatment of osteosarcoma at the molecular level.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang F, Zhu Y, Fan G and Hu S: Photodynamic therapy reduces the inhibitory effect of osteosarcoma cells on dendritic cells by upregulating HSP70. Oncol Lett 16: 5034-5040, 2018.
APA
Zhang, F., Zhu, Y., Fan, G., & Hu, S. (2018). Photodynamic therapy reduces the inhibitory effect of osteosarcoma cells on dendritic cells by upregulating HSP70. Oncology Letters, 16, 5034-5040. https://doi.org/10.3892/ol.2018.9322
MLA
Zhang, F., Zhu, Y., Fan, G., Hu, S."Photodynamic therapy reduces the inhibitory effect of osteosarcoma cells on dendritic cells by upregulating HSP70". Oncology Letters 16.4 (2018): 5034-5040.
Chicago
Zhang, F., Zhu, Y., Fan, G., Hu, S."Photodynamic therapy reduces the inhibitory effect of osteosarcoma cells on dendritic cells by upregulating HSP70". Oncology Letters 16, no. 4 (2018): 5034-5040. https://doi.org/10.3892/ol.2018.9322
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang F, Zhu Y, Fan G and Hu S: Photodynamic therapy reduces the inhibitory effect of osteosarcoma cells on dendritic cells by upregulating HSP70. Oncol Lett 16: 5034-5040, 2018.
APA
Zhang, F., Zhu, Y., Fan, G., & Hu, S. (2018). Photodynamic therapy reduces the inhibitory effect of osteosarcoma cells on dendritic cells by upregulating HSP70. Oncology Letters, 16, 5034-5040. https://doi.org/10.3892/ol.2018.9322
MLA
Zhang, F., Zhu, Y., Fan, G., Hu, S."Photodynamic therapy reduces the inhibitory effect of osteosarcoma cells on dendritic cells by upregulating HSP70". Oncology Letters 16.4 (2018): 5034-5040.
Chicago
Zhang, F., Zhu, Y., Fan, G., Hu, S."Photodynamic therapy reduces the inhibitory effect of osteosarcoma cells on dendritic cells by upregulating HSP70". Oncology Letters 16, no. 4 (2018): 5034-5040. https://doi.org/10.3892/ol.2018.9322
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