Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2018 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2018 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

A dosimetric study on radiation‑induced hypothyroidism following intensity‑modulated radiotherapy in patients with nasopharyngeal carcinoma

  • Authors:
    • Yumei Xu
    • Zhiying Shao
    • Tianyou Tang
    • Guihong Liu
    • Yuanhu Yao
    • Jianshe Wang
    • Longzhen Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221006, P.R. China, Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221006, P.R. China
  • Pages: 6126-6132
    |
    Published online on: August 20, 2018
       https://doi.org/10.3892/ol.2018.9332
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The objective of the present study was to investigate the association between thyroid gland‑dosimetric parameters and hypothyroidism induced by intensity‑modulated radiotherapy in patients with nasopharyngeal carcinoma (NPC). A total of 52 patients with NPC treated in the Department of Radiation Oncology of The Affiliated Hospital of Xuzhou Medical University, from May 2008 to December 2016 were retrospectively enrolled in the present study and divided into two groups based on thyroid function: The euthyroid and hypothyroid groups. The association between hypothyroidism and clinical or dosimetric parameters were analyzed. Females had a significantly increased probability of suffering from radiation‑induced hypothyroidism (RIHT), compared with males (P=0.010). The occurrence of RIHT was significantly negatively associated with thyroid volume prior to radiotherapy (P=0.048). Furthermore, the mean dose (Dmean) and V50 in the hypothyroidism group were significantly increased, compared with the euthyroidism group (P=0.017 and P=0.023, respectively). During the treatment optimization period, dose constraints associated with the thyroid gland demonstrated a significantly protective effect on thyroid function compared with the unconstrained group (P=0.034). According to the receiver operating characteristic curves, the threshold value was 5,160 cGy for Dmean and 54.5% for V50. The 3‑year cumulative incidence of RIHT was 67.8% when the Dmean value was >5,160 cGy and 44.6% when the Dmean was <5,160 cGy (log rank test, P=0.036). Furthermore, the 3‑year cumulative incidence was 66.1% when the V50 was >54.5%, and 29.9% when the V50 was <54.5% (log rank test, P=0.025). In conclusion, RIHT is associated with radiation dose, particularly with Dmean and V50 of the thyroid gland. Dose constraints associated with the thyroid gland significantly reduced the incidence of hypothyroidism compared with the unconstrained group.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Yi HM, Yi H, Zhu JF, Xiao T, Lu SS, Guan YJ and Xiao ZQ: A five-variable signature predicts radioresistance and prognosis in nasopharyngeal carcinoma patients receiving radical radiotherapy. Tumour Biol. 37:2941–2949. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Boomsma MJ, Bijl HP and Langendijk JA: Radiation-induced hypothyroidism in head and neck cancer patients: A systematic review. Radiother Oncol. 99:1–5. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Vanderpump MP and Tunbridge WM: Epidemiology and prevention of clinical and subclinical hypothyroidism. Thyroid. 12:839–847. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL and Trotti A: AJCC cancer staging manual. 7th. Springer-Verlag; New York, NY: 2010

5 

Tian YM, Xiao WW, Bai L, Liu XW, Zhao C, Lu TX and Han F: Impact of primary tumor volume and location on the prognosis of patients with locally recurrent nasopharyngeal carcinoma. Chin J Cancer. 34:247–253. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Duntas LH and Brenta G: The effect of thyroid disorders on lipid levels and metabolism. Med Clin North Am. 96:269–281. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Laulund AS, Nybo M, Brix TH, Abrahamsen B, Jørgensen HL and Hegedüs L: Duration of thyroid dysfunction correlates with all-cause mortality. The OPENTHYRO register cohort. PLoS One. 9:e1104372014. View Article : Google Scholar : PubMed/NCBI

8 

Amin MB, Edge S, Greene F, Byrd DR, Brookland RK, Washington MK, Gershenwald JE, Compton CC, Hess KR, Sullivan DC, et al: AJCC Cancer Staging Manual. Eigth edition. Springer-Verlag; New York, NY: 2017, View Article : Google Scholar

9 

Zohar Y, Tovim RB, Laurian N and Laurian L: Thyroid function following radiation and surgical therapy in head and neck malignancy. Head Neck Surg. 6:948–952. 1984. View Article : Google Scholar : PubMed/NCBI

10 

Hancock SL, Cox RS and McDougall IR: Thyroid disease after treatment of Hodgkin'S disease. N Engl J Med. 325:599–605. 1991. View Article : Google Scholar : PubMed/NCBI

11 

Peng YL, Chen L, Shen GZ, Li YN, Yao JJ, Xiao WW, Yang L, Zhou S, Li JX, Cheng WQ, et al: Interobserver variations in the delineation of target volumes and organs at risk and their impact on dose distribution in intensity-modulated radiation therapy for nasopharyngeal carcinoma. Oral Oncol. 82:1–7. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Mercado G, Adelstein DJ, Saxton JP, Secic M, Larto MA and Lavertu P: Hypothyroidism: A frequent event after radiotherapy and after radiotherapy with chemotherapy for patients with head and neck carcinoma. Cancer. 92:2892–2897. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Tell R, Lundell G, Nilsson B, Sjödin H, Lewin F and Lewensohn R: Long-term incidence of hypothyroidism after radiotherapy in patients with head-and-neck cancer. Int J Radiat Oncol Biol Phys. 60:395–400. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M and Pacelli R: Development of multivariate NTCP models for radiation-induced hypothyroidism: A comparative analysis. Radiat Oncol. 7:2242012. View Article : Google Scholar : PubMed/NCBI

15 

Feen Rønjom M: Radiation-induced hypothyroidism after treatment of head and neck cancer. Dan Med J. 63:2016.

16 

Lin Z, Wu VW, Lin J, Feng H and Chen L: A longitudinal study on the radiation-induced thyroid gland changes after external beam radiotherapy of nasopharyngeal carcinoma. Thyroid. 21:19–23. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Tell R, Sjödin H, Lundell G, Lewin F and Lewensohn R: Hypothyroidism after external radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys. 39:303–308. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Diaz R, Jaboin JJ, Morales-Paliza M, Koehler E, Phillips JG, Stinson S, Gilbert J, Chung CH, Murphy BA, Yarbrough WG, et al: Hypothyroidism as a consequence of intensity-modulated radiotherapy with concurrent taxane-based chemotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 77:468–476. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Colevas AD, Read R, Thornhill J, Adak S, Tishler R, Busse P, Li Y and Posner M: Hypothyroidism incidence after multimodality treatment for stage III and IV squamous cell carcinomas of the head and neck. Int J Radiat Oncol Biol Phys. 51:599–604. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Wu YH, Wang HM, Chen HH, Lin CY, Chen EY, Fan KH, Huang SF, Chen IH, Liao CT, Cheng AJ and Chang JT: Hypothyroidism after radiotherapy for nasopharyngeal cancer patients. Int J Radiat Oncol Biol Phys. 76:1133–1139. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Murthy V, Narang K, Ghosh-Laskar S, Gupta T, Budrukkar A and Agrawal JP: Hypothyroidism after 3-dimensional conformal radiotherapy and intensity-modulated radiotherapy for head and neck cancers: Prospective data from 2 randomized controlled trials. Head Neck. 36:1573–1580. 2014. View Article : Google Scholar : PubMed/NCBI

22 

August M, Wang J, Plante D and Wang CC: Complications associated with therapeutic neck radiation. J Oral Maxillofac Surg. 54:1409–1416. 1996. View Article : Google Scholar : PubMed/NCBI

23 

Grande C: Hypothyroidism following radiotherapy for head and neck cancer: Multivariate analysis of risk factors. Radiother Oncol. 25:31–36. 1992. View Article : Google Scholar : PubMed/NCBI

24 

Cella L, Conson M, Caterino M, De Rosa N, Liuzzi R, Picardi M, Grimaldi F, Solla R, Farella A, Salvatore M and Pacelli R: Thyroid V30 predicts radiation-induced hypothyroidism in patients treated with sequential chemo-radiotherapy for Hodgkin's lymphoma. Int J Radiat Oncol Biol Phys. 82:1802–1808. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Kim MY, Yu T and Wu HG: Dose-volumetric parameters for predicting hypothyroidism after radiotherapy for head and neck cancer. Jpn J Clin Oncol. 44:331–337. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Sachdev S, Refaat T, Bacchus ID, Sathiaseelan V and Mittal BB: Thyroid V50 highly predictive of hypothyroidism in head-and-neck cancer patients treated with intensity-modulated radiotherapy (IMRT). Am J Clin Oncol. 40:413–417. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Boomsma MJ, Bijl HP, Christianen ME, Beetz I, Chouvalova O, Steenbakkers RJ, van der Laan BF, Wolffenbuttel BH, Oosting SF, Schilstra C and Langendijk JA: A prospective cohort study on radiation-induced hypothyroidism: Development of an NTCP model. Int J Radiat Oncol Biol Phys. 84:e351–e363. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Akgun Z, Atasoy BM, Ozen Z, Yavuz D, Gulluoglu B, Sengoz M and Abacioglu U: V30 as a predictor for radiation-induced hypothyroidism: A dosimetric analysis in patients who received radiotherapy to the neck. Radiat Oncol. 9:1042014. View Article : Google Scholar : PubMed/NCBI

29 

Fujiwara M, Kamikonya N, Odawara S, Suzuki H, Niwa Y, Takada Y, Doi H, Terada T, Uwa N, Sagawa K and Hirota S: The threshold of hypothyroidism after radiation therapy for head and neck cancer: A retrospective analysis of 116 cases. J Radiat Res. 56:577–582. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Huang S, Wang X, Hu C and Ying H: Hypothalamic-pituitary-thyroid dysfunction induced by intensity-modulated radiotherapy (IMRT) for adult patients with nasopharyngeal carcinoma. Med Oncol. 30:7102013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu Y, Shao Z, Tang T, Liu G, Yao Y, Wang J and Zhang L: A dosimetric study on radiation‑induced hypothyroidism following intensity‑modulated radiotherapy in patients with nasopharyngeal carcinoma. Oncol Lett 16: 6126-6132, 2018.
APA
Xu, Y., Shao, Z., Tang, T., Liu, G., Yao, Y., Wang, J., & Zhang, L. (2018). A dosimetric study on radiation‑induced hypothyroidism following intensity‑modulated radiotherapy in patients with nasopharyngeal carcinoma. Oncology Letters, 16, 6126-6132. https://doi.org/10.3892/ol.2018.9332
MLA
Xu, Y., Shao, Z., Tang, T., Liu, G., Yao, Y., Wang, J., Zhang, L."A dosimetric study on radiation‑induced hypothyroidism following intensity‑modulated radiotherapy in patients with nasopharyngeal carcinoma". Oncology Letters 16.5 (2018): 6126-6132.
Chicago
Xu, Y., Shao, Z., Tang, T., Liu, G., Yao, Y., Wang, J., Zhang, L."A dosimetric study on radiation‑induced hypothyroidism following intensity‑modulated radiotherapy in patients with nasopharyngeal carcinoma". Oncology Letters 16, no. 5 (2018): 6126-6132. https://doi.org/10.3892/ol.2018.9332
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Y, Shao Z, Tang T, Liu G, Yao Y, Wang J and Zhang L: A dosimetric study on radiation‑induced hypothyroidism following intensity‑modulated radiotherapy in patients with nasopharyngeal carcinoma. Oncol Lett 16: 6126-6132, 2018.
APA
Xu, Y., Shao, Z., Tang, T., Liu, G., Yao, Y., Wang, J., & Zhang, L. (2018). A dosimetric study on radiation‑induced hypothyroidism following intensity‑modulated radiotherapy in patients with nasopharyngeal carcinoma. Oncology Letters, 16, 6126-6132. https://doi.org/10.3892/ol.2018.9332
MLA
Xu, Y., Shao, Z., Tang, T., Liu, G., Yao, Y., Wang, J., Zhang, L."A dosimetric study on radiation‑induced hypothyroidism following intensity‑modulated radiotherapy in patients with nasopharyngeal carcinoma". Oncology Letters 16.5 (2018): 6126-6132.
Chicago
Xu, Y., Shao, Z., Tang, T., Liu, G., Yao, Y., Wang, J., Zhang, L."A dosimetric study on radiation‑induced hypothyroidism following intensity‑modulated radiotherapy in patients with nasopharyngeal carcinoma". Oncology Letters 16, no. 5 (2018): 6126-6132. https://doi.org/10.3892/ol.2018.9332
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team