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Article Open Access

MicroRNA‑217 functions as a tumor suppressor in cervical cancer cells through targeting Rho‑associated protein kinase 1

Retraction in: /10.3892/ol.2024.14657
  • Authors:
    • Jing Dong
    • Maoxiu Wang
    • Donghua Ni
    • Lixin Zhang
    • Wen Wang
    • Xiujuan Cui
    • Shijie Fu
    • Shujuan Yao
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Jining Medical University Affiliated Tengzhou Central People's Hospital, Tengzhou, Shandong 277500, P.R. China, Deparment of Clinical Medicine, Anhui Medical University, Meishan Road, Hefei, Anhui 230032, P.R. China
    Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5535-5542
    |
    Published online on: August 20, 2018
       https://doi.org/10.3892/ol.2018.9335
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Abstract

The abnormal expression of microRNAs (miRNAs/miRs) has been widely reported in various tumor types. miR‑217 was demonstrated to be aberrantly expressed in a number of tumors, including pancreatic adenocarcinoma and osteosarcoma; however, its specific expression pattern has never been investigated in cervical cancer cells. Compared with normal control, the level of Rho‑associated protein kinase 1 (ROCK1) expression was markedly increased in cervical cancer tissues and cells compared with that in non‑cancerous tissues and cells. The expression of miR‑217 was significantly reduced in cervical cancer tissues and cell lines. Overexpression of miR‑217 could suppress colony formation and the cell invasion capacity of SiHa and HeLa cells. Flow cytometry indicated that miR‑217 significantly increased cell apoptosis in SiHa and HeLa cells. Dual‑luciferase reporter assays demonstrated that ROCK1 was a target gene of miR‑217. In addition, overexpression of ROCK1 also led to an increased invasion capacity in SiHa cells, even when miR‑217 was inhibited, indicating that the anti‑invasive effects of miR‑217 were mediated through ROCK1. In summary, the results of the present study indicated that miR‑217 functions as a tumor suppressor in cervical cancer cells, primarily by targeting ROCK1.
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Copy and paste a formatted citation
Spandidos Publications style
Dong J, Wang M, Ni D, Zhang L, Wang W, Cui X, Fu S and Yao S: MicroRNA‑217 functions as a tumor suppressor in cervical cancer cells through targeting Rho‑associated protein kinase 1 Retraction in /10.3892/ol.2024.14657. Oncol Lett 16: 5535-5542, 2018.
APA
Dong, J., Wang, M., Ni, D., Zhang, L., Wang, W., Cui, X. ... Yao, S. (2018). MicroRNA‑217 functions as a tumor suppressor in cervical cancer cells through targeting Rho‑associated protein kinase 1 Retraction in /10.3892/ol.2024.14657. Oncology Letters, 16, 5535-5542. https://doi.org/10.3892/ol.2018.9335
MLA
Dong, J., Wang, M., Ni, D., Zhang, L., Wang, W., Cui, X., Fu, S., Yao, S."MicroRNA‑217 functions as a tumor suppressor in cervical cancer cells through targeting Rho‑associated protein kinase 1 Retraction in /10.3892/ol.2024.14657". Oncology Letters 16.5 (2018): 5535-5542.
Chicago
Dong, J., Wang, M., Ni, D., Zhang, L., Wang, W., Cui, X., Fu, S., Yao, S."MicroRNA‑217 functions as a tumor suppressor in cervical cancer cells through targeting Rho‑associated protein kinase 1 Retraction in /10.3892/ol.2024.14657". Oncology Letters 16, no. 5 (2018): 5535-5542. https://doi.org/10.3892/ol.2018.9335
Copy and paste a formatted citation
x
Spandidos Publications style
Dong J, Wang M, Ni D, Zhang L, Wang W, Cui X, Fu S and Yao S: MicroRNA‑217 functions as a tumor suppressor in cervical cancer cells through targeting Rho‑associated protein kinase 1 Retraction in /10.3892/ol.2024.14657. Oncol Lett 16: 5535-5542, 2018.
APA
Dong, J., Wang, M., Ni, D., Zhang, L., Wang, W., Cui, X. ... Yao, S. (2018). MicroRNA‑217 functions as a tumor suppressor in cervical cancer cells through targeting Rho‑associated protein kinase 1 Retraction in /10.3892/ol.2024.14657. Oncology Letters, 16, 5535-5542. https://doi.org/10.3892/ol.2018.9335
MLA
Dong, J., Wang, M., Ni, D., Zhang, L., Wang, W., Cui, X., Fu, S., Yao, S."MicroRNA‑217 functions as a tumor suppressor in cervical cancer cells through targeting Rho‑associated protein kinase 1 Retraction in /10.3892/ol.2024.14657". Oncology Letters 16.5 (2018): 5535-5542.
Chicago
Dong, J., Wang, M., Ni, D., Zhang, L., Wang, W., Cui, X., Fu, S., Yao, S."MicroRNA‑217 functions as a tumor suppressor in cervical cancer cells through targeting Rho‑associated protein kinase 1 Retraction in /10.3892/ol.2024.14657". Oncology Letters 16, no. 5 (2018): 5535-5542. https://doi.org/10.3892/ol.2018.9335
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