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Article

Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate‑derived mercapturic acids

  • Authors:
    • Kamila Cwiklowska
    • Mike‑Andrew Westhoff
    • Simon Freisinger
    • Annika Dwucet
    • Marc‑Eric Halatsch
    • Uwe Knippschild
    • Klaus‑Michael Debatin
    • Reinhold Schirmbeck
    • Lukasz Winiarski
    • Jozef Oleksyszyn
    • Christian Rainer Wirtz
    • Timo Burster
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Surgery Center, Ulm University Medical Center, D‑89081 Ulm, Germany, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, D‑89081 Ulm, Germany, Department of General and Visceral Surgery, Surgery Center, Ulm University Medical Center, D‑89081 Ulm, Germany, Internal Medicine I, Ulm University Medical Center, D‑89081 Ulm, Germany, Faculty of Chemistry, Wroclaw University of Technology, 50‑370 Wroclaw, Poland
  • Pages: 6181-6187
    |
    Published online on: August 21, 2018
       https://doi.org/10.3892/ol.2018.9347
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Abstract

Glioblastoma is the most aggressive tumor of the central nervous system and is manifested by diffuse invasion of glioblastoma stem cells into the healthy tissue, chemoresistance and recurrence. Despite aggressive therapy, consisting of maximal surgical resection, radiotherapy and chemotherapy with temozolomide (Temodal®), life expectancy of patients with glioblastoma is typically less than 15 months. In general, natural isothiocyanates isolated from plants of the Cruciferae family are selectively cytotoxic to tumor cells. It has been demonstrated previously that diisothiocyanate‑derived mercapturic acids are highly cytotoxic to colon cancer cells. In the present study, the application of diisothiocyanate‑derived mercapturic acids led to a decrease in the viability of an established glioblastoma cell line, primary patient‑derived sphere‑cultured stem cell‑enriched cell populations (SCs), and cells differentiated from SCs. Consequently, targeting glioblastoma cells by diisothiocyanate‑derived mercapturic acids is a promising approach to restrict tumor cell growth and may be a novel therapeutic intervention for the treatment of glioblastoma.
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Copy and paste a formatted citation
Spandidos Publications style
Cwiklowska K, Westhoff MA, Freisinger S, Dwucet A, Halatsch ME, Knippschild U, Debatin KM, Schirmbeck R, Winiarski L, Oleksyszyn J, Oleksyszyn J, et al: Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate‑derived mercapturic acids. Oncol Lett 16: 6181-6187, 2018.
APA
Cwiklowska, K., Westhoff, M., Freisinger, S., Dwucet, A., Halatsch, M., Knippschild, U. ... Burster, T. (2018). Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate‑derived mercapturic acids. Oncology Letters, 16, 6181-6187. https://doi.org/10.3892/ol.2018.9347
MLA
Cwiklowska, K., Westhoff, M., Freisinger, S., Dwucet, A., Halatsch, M., Knippschild, U., Debatin, K., Schirmbeck, R., Winiarski, L., Oleksyszyn, J., Wirtz, C. R., Burster, T."Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate‑derived mercapturic acids". Oncology Letters 16.5 (2018): 6181-6187.
Chicago
Cwiklowska, K., Westhoff, M., Freisinger, S., Dwucet, A., Halatsch, M., Knippschild, U., Debatin, K., Schirmbeck, R., Winiarski, L., Oleksyszyn, J., Wirtz, C. R., Burster, T."Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate‑derived mercapturic acids". Oncology Letters 16, no. 5 (2018): 6181-6187. https://doi.org/10.3892/ol.2018.9347
Copy and paste a formatted citation
x
Spandidos Publications style
Cwiklowska K, Westhoff MA, Freisinger S, Dwucet A, Halatsch ME, Knippschild U, Debatin KM, Schirmbeck R, Winiarski L, Oleksyszyn J, Oleksyszyn J, et al: Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate‑derived mercapturic acids. Oncol Lett 16: 6181-6187, 2018.
APA
Cwiklowska, K., Westhoff, M., Freisinger, S., Dwucet, A., Halatsch, M., Knippschild, U. ... Burster, T. (2018). Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate‑derived mercapturic acids. Oncology Letters, 16, 6181-6187. https://doi.org/10.3892/ol.2018.9347
MLA
Cwiklowska, K., Westhoff, M., Freisinger, S., Dwucet, A., Halatsch, M., Knippschild, U., Debatin, K., Schirmbeck, R., Winiarski, L., Oleksyszyn, J., Wirtz, C. R., Burster, T."Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate‑derived mercapturic acids". Oncology Letters 16.5 (2018): 6181-6187.
Chicago
Cwiklowska, K., Westhoff, M., Freisinger, S., Dwucet, A., Halatsch, M., Knippschild, U., Debatin, K., Schirmbeck, R., Winiarski, L., Oleksyszyn, J., Wirtz, C. R., Burster, T."Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate‑derived mercapturic acids". Oncology Letters 16, no. 5 (2018): 6181-6187. https://doi.org/10.3892/ol.2018.9347
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