Role of nutritional support for postoperative recovery of respiratory function in patients with primary lung cancer

Yang,Jinhong; Zhang,Qianqian; Wang,Xiaoli

doi:10.3892/ol.2018.9348

Role of nutritional support for postoperative recovery of respiratory function in patients with primary lung cancer

Authors:
- Jinhong Yang
- Qianqian Zhang
- Xiaoli Wang
View Affiliations

Affiliations: Department of Medical Oncology, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China, Department of Radiotherapy, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China
Published online on: August 22, 2018 https://doi.org/10.3892/ol.2018.9348
Pages: 5978-5982
Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

This study explored the role of nutritional support for postoperative recovery of respiratory function in patients with primary lung cancer. Clinical data of 182 patients with primary lung cancer who were admitted to Weifang People's Hospital from January 2013 to December 2015 and underwent lung cancer surgery, were collected and retrospectively analyzed. According to the postoperative diet plan, patients were divided into two groups: General diet group (n=80) and nutrition therapy group (n=102). Patients in the general diet group were given a general diet without any nutritional instruction, whereas the patients in the nutrition therapy group were given an enteral nutritional supplement in addition to a general diet. The changes of nutritional indices, recovery status of respiratory function and incidence of adverse events for patients in the two groups were observed, and the data were analyzed statistically. At day 14 after the therapy started, the body mass index, mid-arm circumference and triceps skinfold of patients in the nutrition therapy group were significantly better than those in the general diet group (P<0.05). More significant improvements in levels of hemoglobin, serum albumin and prealbumin were observed in the nutrition therapy group, and the differences in comparison with levels in the general diet group were statistically significant (P<0.05). The respiratory function was more significantly improved for patients in the nutrition therapy group as well, compared to patients in the general diet group (P<0.05). At the end of 1-year follow-up, incidences of malnutrition, lung infection and mortality in the nutrition therapy group were lower than that of the general diet group (P<0.05). The positive impact of appropriate nutritional support on recovery of postoperative respiratory function improved overall outcomes of patients with lung cancer and reduced mortality as well. The nutrition therapy is worth further clinical study.

View Figures

View References

1	Chang S, Buist DS, Reid M, Terry MB and Trentham-Dietz A: The characteristics and training of professionals in cancer prevention and control: A survey of the American Society for Preventive Oncology. Cancer Epidemiol Biomarkers Prev. 13:1094–1098. 2004.PubMed/NCBI
2	Kyle UG, Schneider SM, Pirlich M, Lochs H, Hebuterne X and Pichard C: Does nutritional risk, as assessed by Nutritional Risk Index, increase during hospital stay? A multinational population-based study. Clin Nutr. 24:516–524. 2005. View Article : Google Scholar : PubMed/NCBI
3	Zhang BN, Chen WQ, Zhang X and Qiao YL: China faces a challenge of breast cancer prevention and control. Zhonghua Zhong Liu Za Zhi. 38:798–800. 2016.(In Chinese). PubMed/NCBI
4	Aziz EF, Javed F, Pratap B, Musat D, Nader A, Pulimi S, Alivar CL, Herzog E and Kukin ML: Malnutrition as assessed by nutritional risk index is associated with worse outcome in patients admitted with acute decompensated heart failure: An ACAP-HF data analysis. Heart Int. 6:e22011. View Article : Google Scholar : PubMed/NCBI
5	Khatib O and Aljurf M: Cancer prevention and control in the Eastern Mediterranean region: The need for a public health approach. Hematol Oncol Stem Cell Ther. 1:44–52. 2008. View Article : Google Scholar : PubMed/NCBI
6	Gyula O, András B, Zoltán B, Katalin B, Attila C, Janos F, Maria G, Akos H, Lászlo K, Lászlo K, et al: NEFMI - Nemzeti Erőforrás Minisztérium (Department of Human Resources): Basic principles for the prevention, diagnosis and therapy of lung cancer. Magy Onkol. 56:114–132. 2012.(In Hungarian). PubMed/NCBI
7	Koike T, Yamato Y, Yoshiya K, Shimoyama T and Suzuki R: Intentional limited pulmonary resection for peripheral T1 N0 M0 small-sized lung cancer. J Thorac Cardiovasc Surg. 125:924–928. 2003. View Article : Google Scholar : PubMed/NCBI
8	Escortell SR and Reig GM: Enteral nutrition on the nurtritional status of cancer. Nutr Hosp. 32:1408–1416. 2013.
9	Goeckenjan G, Sitter H, Thomas M, Branscheid D, Flentje M, Griesinger F, Niederle N, Stuschke M, Blum T, Deppermann KM, et al: Prevention, diagnosis, therapy, and follow-up of lung cancer. Pneumologie. 64:1–164. 2010.(In German). View Article : Google Scholar : PubMed/NCBI
10	Yang CL, Ma LX, Sun SY, Cui HX, Li ZL and Cheng Y: Efficiency and adverse effects of the effective therapy applying etoposide + cisplatin and its subsequent maintenance therapy with different durations in patients with small cell lung cancer. Zhonghua Zhong Liu Za Zhi. 38:454–459. 2016.(In Chinese). PubMed/NCBI
11	Stoelben E, Huber RM, Müller RP and Wolf J: Multimodality therapy for lung cancer. Internist (Berl). 51:1348–1357. 2010.(In German). View Article : Google Scholar : PubMed/NCBI
12	Huhmann MB and August DA: Review of American Society for Parenteral and Enteral Nutrition (ASPEN) Clinical guidelines for nutrition support in cancer patients: Nutrition screening and assessment. Nutr Clin Pract. 23:182–188. 2008. View Article : Google Scholar : PubMed/NCBI
13	Zhang X, Zang J, Xu J, Bai C, Qin Y, Liu K, Wu C, Wu M, He Q, Zhang S, et al: Maintenance therapy with continuous or switch strategy in advanced non-small cell lung cancer: A systematic review and meta-analysis. Chest. 140:117–126. 2011. View Article : Google Scholar : PubMed/NCBI
14	Aufaure M and Grigoroiu M: Thoracic surgery for lung cancer. Rev Infirm. 2:19–22. 2012.(In French).
15	Wang X, Pan L, Zhang P, Liu X, Wu G, Wang Y, Liu Y, Li N and Li J: Enteral nutrition improves clinical outcome and shortens hospital stay after cancer surgery. J Invest Surg. 23:309–313. 2010. View Article : Google Scholar : PubMed/NCBI
16	Akashi Y, Hiki N, Nunobe S, Jiang X and Yamaguchi T: Safe management of anastomotic leakage after gastric cancer surgery with enteral nutrition via a nasointestinal tube. Langenbecks Arch Surg. 397:737–744. 2012. View Article : Google Scholar : PubMed/NCBI
17	Aoyama T, Hayashi T, Fujikawa H, Ogata T, Cho H, Wada H, Kitani Y, Yukawa N, Oshima T, Rino Y, et al: Effect of enteral nutrition enriched with eicosapentaenoic acid on body weight loss and compliance with S-1 adjuvant chemotherapy after gastric cancer surgery. Gan To Kagaku Ryoho. 40:2289–2291. 2013.(In Japanese). PubMed/NCBI
18	Mi L, Zhong B, Zhang DL, Zhou YB and Wang DS: Effect of early oral enteral nutrition on clinical outcomes after gastric cancer surgery. Zhonghua Wei Chang Wai Ke Za Zhi. 15:464–467. 2012.(In Chinese). PubMed/NCBI
19	Huang D, Sun Z, Huang J and Shen Z: Early enteral nutrition in combination with parenteral nutrition in elderly patients after surgery due to gastrointestinal cancer. Int J Clin Exp Med. 8:13937–13945. 2015.PubMed/NCBI
20	Romaguera D, Gracia-Lavedan E, Molinuevo A, de Batlle J, Mendez M, Moreno V, Vidal C, Castelló A, Pérez-Gómez B, Martín V, et al: Adherence to nutrition-based cancer prevention guidelines and breast, prostate and colorectal cancer risk in the MCC-Spain case-control study. Int J Cancer. 141:83–93. 2017. View Article : Google Scholar : PubMed/NCBI
21	Nishino M, Jackman DM, Hatabu H, Yeap BY, Cioffredi LA, Yap JT, Jänne PA, Johnson BE and Van den Abbeele AD: New Response Evaluation Criteria in Solid Tumors (RECIST) guidelines for advanced non-small cell lung cancer: Comparison with original RECIST and impact on assessment of tumor response to targeted therapy. AJR Am J Roentgenol. 195:W221–8. 2010. View Article : Google Scholar : PubMed/NCBI
22	Colt HG, Murgu SD, Korst RJ, Slatore CG, Unger M and Quadrelli S: Follow-up and surveillance of the patient with lung cancer after curative-intent therapy: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 143:e437S–e454S. 2013. View Article : Google Scholar : PubMed/NCBI