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Interaction of polymorphisms in xeroderma pigmentosum group C with cigarette smoking and pancreatic cancer risk

  • Authors:
    • Xiao‑Hui Liang
    • Dong Yan
    • Jia‑Xing Zhao
    • Wei Ding
    • Xin‑Jian Xu
    • Xi‑Yan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Hypertension, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China, Department of Hepatopancreatobiliary Surgery, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China, Department of Pancreatic Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China, Xinjiang Research Institute of Cancer Prevention and Control, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China
    Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5631-5638
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    Published online on: August 23, 2018
       https://doi.org/10.3892/ol.2018.9350
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Abstract

The aim of the present study was to evaluate the association between xeroderma pigmentosum group C (XPC) polymorphisms and pancreatic cancer (PC) risk. A total of 7 XPC tagging SNPs (tag‑SNPs) were selected from the International HapMap Project Databases (rs2228001A/C, rs2470353G/C, rs2228000C/T, rs3731114C/G, rs3729587G/C, rs2607775C/G and rs3731055G/A) and were genotyped in 205 patients with PC and 230 non‑cancer control subjects using a SNaPshot assay. The C allelic gene frequency of rs2470353 was higher in patients with PC compared with that in the control group (P=0.003). Compared with the GG gene type, PC risk was increased in subjects with GC and GC+CC gene types (P=0.012 and P=0.006, respectively). PC risk increased 3.505‑fold for the subjects who were heavy smokers (tobacco, ≥25 packets/year) with the GC+CC gene type (P=0.008). The G allelic gene frequency of rs2607775 was higher in PC patients compared with that in the control group (P=0.003). Compared with the CC gene type, PC risk increased in subjects with CG and CG+GG gene types (P=0.013 and P=0.005, respectively). Furthermore, PC risk increased 3.950‑fold in subjects who were heavy smokers (tobacco, ≥25 packets/year) with the CG+GG gene type (P=0.001). Haplotype analysis further revealed that the CCC haplotype of rs2228000, rs3731114 and rs3729587 increased PC risk (odds ratio, 1.610; 95% confidence interval, 1.035‑2.481; P=0.034). The present study revealed that XPC gene polymorphisms could increase the risk of PC in the study population, particularly among heavy smokers.
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Copy and paste a formatted citation
Spandidos Publications style
Liang XH, Yan D, Zhao JX, Ding W, Xu XJ and Wang XY: Interaction of polymorphisms in xeroderma pigmentosum group C with cigarette smoking and pancreatic cancer risk. Oncol Lett 16: 5631-5638, 2018.
APA
Liang, X., Yan, D., Zhao, J., Ding, W., Xu, X., & Wang, X. (2018). Interaction of polymorphisms in xeroderma pigmentosum group C with cigarette smoking and pancreatic cancer risk. Oncology Letters, 16, 5631-5638. https://doi.org/10.3892/ol.2018.9350
MLA
Liang, X., Yan, D., Zhao, J., Ding, W., Xu, X., Wang, X."Interaction of polymorphisms in xeroderma pigmentosum group C with cigarette smoking and pancreatic cancer risk". Oncology Letters 16.5 (2018): 5631-5638.
Chicago
Liang, X., Yan, D., Zhao, J., Ding, W., Xu, X., Wang, X."Interaction of polymorphisms in xeroderma pigmentosum group C with cigarette smoking and pancreatic cancer risk". Oncology Letters 16, no. 5 (2018): 5631-5638. https://doi.org/10.3892/ol.2018.9350
Copy and paste a formatted citation
x
Spandidos Publications style
Liang XH, Yan D, Zhao JX, Ding W, Xu XJ and Wang XY: Interaction of polymorphisms in xeroderma pigmentosum group C with cigarette smoking and pancreatic cancer risk. Oncol Lett 16: 5631-5638, 2018.
APA
Liang, X., Yan, D., Zhao, J., Ding, W., Xu, X., & Wang, X. (2018). Interaction of polymorphisms in xeroderma pigmentosum group C with cigarette smoking and pancreatic cancer risk. Oncology Letters, 16, 5631-5638. https://doi.org/10.3892/ol.2018.9350
MLA
Liang, X., Yan, D., Zhao, J., Ding, W., Xu, X., Wang, X."Interaction of polymorphisms in xeroderma pigmentosum group C with cigarette smoking and pancreatic cancer risk". Oncology Letters 16.5 (2018): 5631-5638.
Chicago
Liang, X., Yan, D., Zhao, J., Ding, W., Xu, X., Wang, X."Interaction of polymorphisms in xeroderma pigmentosum group C with cigarette smoking and pancreatic cancer risk". Oncology Letters 16, no. 5 (2018): 5631-5638. https://doi.org/10.3892/ol.2018.9350
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