Open Access

Apatinib suppresses cell growth and metastasis and promotes antitumor activity of temozolomide in glioma

  • Authors:
    • Chao Wang
    • Man Jiang
    • Helei Hou
    • Qiang Lin
    • Zhiyong Yan
    • Xiaochun Zhang
  • View Affiliations

  • Published online on: August 23, 2018     https://doi.org/10.3892/ol.2018.9355
  • Pages: 5607-5614
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Apatinib, a small‑molecule multi‑targeted tyrosine kinase inhibitor, is widely used to treat various types of solid tumors. In the present study, it was investigated whether apatinib has therapeutic potential for glioma. Cell Counting Kit‑8 and colony formation assays were utilized to determine the cell viability of p53‑ and EGFR‑mutated U251MG glioma cells, and wild‑type U‑87MG ATCC glioma cells. Furthermore, apoptosis, and the invasion and migration abilities of glioma cells were investigated by flow cytometry, invasion assays and wound‑healing assays. The potential of the combination of apatinib with temozolomide (TMZ) for glioma therapy was also investigated. The results demonstrate that apatinib significantly inhibited cell proliferation and colony formation through promoting cell apoptosis in p53‑ and EGFR‑mutated and wild‑type glioma cells. Cell invasion and migration abilities were notably decreased following treatment with apatinib. Overall, the present study indicates a synergistic antitumor effect of apatinib and TMZ in glioma, and presents a basis for the use of apatinib in glioma treatment.
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November-2018
Volume 16 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang C, Jiang M, Hou H, Lin Q, Yan Z and Zhang X: Apatinib suppresses cell growth and metastasis and promotes antitumor activity of temozolomide in glioma. Oncol Lett 16: 5607-5614, 2018
APA
Wang, C., Jiang, M., Hou, H., Lin, Q., Yan, Z., & Zhang, X. (2018). Apatinib suppresses cell growth and metastasis and promotes antitumor activity of temozolomide in glioma. Oncology Letters, 16, 5607-5614. https://doi.org/10.3892/ol.2018.9355
MLA
Wang, C., Jiang, M., Hou, H., Lin, Q., Yan, Z., Zhang, X."Apatinib suppresses cell growth and metastasis and promotes antitumor activity of temozolomide in glioma". Oncology Letters 16.5 (2018): 5607-5614.
Chicago
Wang, C., Jiang, M., Hou, H., Lin, Q., Yan, Z., Zhang, X."Apatinib suppresses cell growth and metastasis and promotes antitumor activity of temozolomide in glioma". Oncology Letters 16, no. 5 (2018): 5607-5614. https://doi.org/10.3892/ol.2018.9355