Open Access

Leptin and its receptor in glucose metabolism of T‑cell lymphoma

  • Authors:
    • Tian‑Jie Han
    • Hong‑Zhi Xu
    • Jun‑Shan Li
    • Ling‑Yun Geng
    • Xin‑Yu Li
    • Xiang‑Xiang Zhou
    • Xin Wang
  • View Affiliations

  • Published online on: August 23, 2018     https://doi.org/10.3892/ol.2018.9356
  • Pages: 5838-5846
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

T‑cell lymphoma (TCL) is a group of heterogeneous disorders with a poor response to conventional treatment. In order to identify novel therapeutic targets, the present study investigated the effect of leptin and its receptor on glucose metabolism in TCL. The expression of the leptin receptor (ObR), and glucose transporter (Glut)1 and 4 was detected in TCL and reactive lymphoid hyperplasia (RLH) tissues by immunohistochemical analysis. A higher level of ObR expression was observed in the TCL tissues than in the RLH tissues (58.3 vs. 22.2%; P=0.012), and ObR overexpression was associated with high expression of Glut1 (P=0.007). In vitro analysis using the human TCL MOLT‑3 cell line demonstrated that leptin stimulated cell glucose uptake via promoting recruitment and expression of Glut1, effects which were abolished by ObR‑specific small interfering RNA (siRNA). Additionally, MOLT‑3 cell viability was also increased following leptin treatment. ObR‑specific siRNA abolished these responses. In conclusion, these results suggested that leptin serves a critical role in TCL glucose uptake via the ObR.
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November-2018
Volume 16 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Han TJ, Xu HZ, Li JS, Geng LY, Li XY, Zhou XX and Wang X: Leptin and its receptor in glucose metabolism of T‑cell lymphoma. Oncol Lett 16: 5838-5846, 2018
APA
Han, T., Xu, H., Li, J., Geng, L., Li, X., Zhou, X., & Wang, X. (2018). Leptin and its receptor in glucose metabolism of T‑cell lymphoma. Oncology Letters, 16, 5838-5846. https://doi.org/10.3892/ol.2018.9356
MLA
Han, T., Xu, H., Li, J., Geng, L., Li, X., Zhou, X., Wang, X."Leptin and its receptor in glucose metabolism of T‑cell lymphoma". Oncology Letters 16.5 (2018): 5838-5846.
Chicago
Han, T., Xu, H., Li, J., Geng, L., Li, X., Zhou, X., Wang, X."Leptin and its receptor in glucose metabolism of T‑cell lymphoma". Oncology Letters 16, no. 5 (2018): 5838-5846. https://doi.org/10.3892/ol.2018.9356