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Leptin and its receptor in glucose metabolism of T‑cell lymphoma

  • Authors:
    • Tian‑Jie Han
    • Hong‑Zhi Xu
    • Jun‑Shan Li
    • Ling‑Yun Geng
    • Xin‑Yu Li
    • Xiang‑Xiang Zhou
    • Xin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, P.R. China, Department of Gastroenterology, Tai'an City Central Hospital, Tai'an, Shandong 271000, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5838-5846
    |
    Published online on: August 23, 2018
       https://doi.org/10.3892/ol.2018.9356
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Abstract

T‑cell lymphoma (TCL) is a group of heterogeneous disorders with a poor response to conventional treatment. In order to identify novel therapeutic targets, the present study investigated the effect of leptin and its receptor on glucose metabolism in TCL. The expression of the leptin receptor (ObR), and glucose transporter (Glut)1 and 4 was detected in TCL and reactive lymphoid hyperplasia (RLH) tissues by immunohistochemical analysis. A higher level of ObR expression was observed in the TCL tissues than in the RLH tissues (58.3 vs. 22.2%; P=0.012), and ObR overexpression was associated with high expression of Glut1 (P=0.007). In vitro analysis using the human TCL MOLT‑3 cell line demonstrated that leptin stimulated cell glucose uptake via promoting recruitment and expression of Glut1, effects which were abolished by ObR‑specific small interfering RNA (siRNA). Additionally, MOLT‑3 cell viability was also increased following leptin treatment. ObR‑specific siRNA abolished these responses. In conclusion, these results suggested that leptin serves a critical role in TCL glucose uptake via the ObR.
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Copy and paste a formatted citation
Spandidos Publications style
Han TJ, Xu HZ, Li JS, Geng LY, Li XY, Zhou XX and Wang X: Leptin and its receptor in glucose metabolism of T‑cell lymphoma. Oncol Lett 16: 5838-5846, 2018.
APA
Han, T., Xu, H., Li, J., Geng, L., Li, X., Zhou, X., & Wang, X. (2018). Leptin and its receptor in glucose metabolism of T‑cell lymphoma. Oncology Letters, 16, 5838-5846. https://doi.org/10.3892/ol.2018.9356
MLA
Han, T., Xu, H., Li, J., Geng, L., Li, X., Zhou, X., Wang, X."Leptin and its receptor in glucose metabolism of T‑cell lymphoma". Oncology Letters 16.5 (2018): 5838-5846.
Chicago
Han, T., Xu, H., Li, J., Geng, L., Li, X., Zhou, X., Wang, X."Leptin and its receptor in glucose metabolism of T‑cell lymphoma". Oncology Letters 16, no. 5 (2018): 5838-5846. https://doi.org/10.3892/ol.2018.9356
Copy and paste a formatted citation
x
Spandidos Publications style
Han TJ, Xu HZ, Li JS, Geng LY, Li XY, Zhou XX and Wang X: Leptin and its receptor in glucose metabolism of T‑cell lymphoma. Oncol Lett 16: 5838-5846, 2018.
APA
Han, T., Xu, H., Li, J., Geng, L., Li, X., Zhou, X., & Wang, X. (2018). Leptin and its receptor in glucose metabolism of T‑cell lymphoma. Oncology Letters, 16, 5838-5846. https://doi.org/10.3892/ol.2018.9356
MLA
Han, T., Xu, H., Li, J., Geng, L., Li, X., Zhou, X., Wang, X."Leptin and its receptor in glucose metabolism of T‑cell lymphoma". Oncology Letters 16.5 (2018): 5838-5846.
Chicago
Han, T., Xu, H., Li, J., Geng, L., Li, X., Zhou, X., Wang, X."Leptin and its receptor in glucose metabolism of T‑cell lymphoma". Oncology Letters 16, no. 5 (2018): 5838-5846. https://doi.org/10.3892/ol.2018.9356
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