Open Access

Correlation of nm 23 expression with pharyngeal cancer and patient prognoses

  • Authors:
    • Wenzhong Wei
    • Xin Wei
    • Xiao Liang
  • View Affiliations

  • Published online on: August 31, 2018     https://doi.org/10.3892/ol.2018.9375
  • Pages: 5667-5672
  • Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study investigated the expression of non-metastasis 23 (nm 23) in laryngeal cancer tissues and analyzed its correlation with the prognoses of laryngeal cancer patients. A total of 122 laryngeal cancer patients who were admitted to The Affiliated Hospital of Jining Medical College from June 2009 to June 2012, and 30 normal laryngeal mucosal tissues were selected as the control group. Immunohistochemical staining method was used to test the expression of nm 23 in tissues. Quantitative-polymerase chain reaction (q-PCR) and western blotting were conducted to test the expression of nm 23 in tissues at the gene and protein levels, respectively. Moreover, the prognoses of patients were analyzed. The positive expression rate (90.00%) of nm 23 in the normal laryngeal mucosal tissues was markedly higher than that in laryngeal cancer tissues (56.56%) (p<0.05). The expression of nm 23 proteins was correlated with the clinical staging of laryngeal cancer and the metastasis of lymph nodes (p<0.05). The expression of both nm 23 genes and proteins in the laryngeal cancer tissues were significantly lower than those in the normal laryngeal mucosal tissues (p<0.05). The survival rate of the positive nm 23 expression was substantially higher than that of the negative expression with a statistically significant difference (p<0.01). In conclusion, the expression of nm 23 proteins plays an important role in the development and metastasis of laryngeal cancer and may be taken as one of the indicators to evaluate the prognoses of such patients.
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November-2018
Volume 16 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wei W, Wei X and Liang X: Correlation of nm 23 expression with pharyngeal cancer and patient prognoses. Oncol Lett 16: 5667-5672, 2018
APA
Wei, W., Wei, X., & Liang, X. (2018). Correlation of nm 23 expression with pharyngeal cancer and patient prognoses. Oncology Letters, 16, 5667-5672. https://doi.org/10.3892/ol.2018.9375
MLA
Wei, W., Wei, X., Liang, X."Correlation of nm 23 expression with pharyngeal cancer and patient prognoses". Oncology Letters 16.5 (2018): 5667-5672.
Chicago
Wei, W., Wei, X., Liang, X."Correlation of nm 23 expression with pharyngeal cancer and patient prognoses". Oncology Letters 16, no. 5 (2018): 5667-5672. https://doi.org/10.3892/ol.2018.9375