Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2018 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2018 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Correlation of nm 23 expression with pharyngeal cancer and patient prognoses

Retraction in: /10.3892/ol.2025.15061
  • Authors:
    • Wenzhong Wei
    • Xin Wei
    • Xiao Liang
  • View Affiliations / Copyright

    Affiliations: E.N.T. Department, The Affiliated Hospital of Jining Medical College, Jining, Shandong 272000, P.R. China, Emergency Department, The Affiliated Hospital of Jining Medical College, Jining, Shandong 272000, P.R. China, E.N.T. Department, Qufu City Hospital of Traditional Chinese Medicine, Qufu, Shandong 273100, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5667-5672
    |
    Published online on: August 31, 2018
       https://doi.org/10.3892/ol.2018.9375
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study investigated the expression of non-metastasis 23 (nm 23) in laryngeal cancer tissues and analyzed its correlation with the prognoses of laryngeal cancer patients. A total of 122 laryngeal cancer patients who were admitted to The Affiliated Hospital of Jining Medical College from June 2009 to June 2012, and 30 normal laryngeal mucosal tissues were selected as the control group. Immunohistochemical staining method was used to test the expression of nm 23 in tissues. Quantitative-polymerase chain reaction (q-PCR) and western blotting were conducted to test the expression of nm 23 in tissues at the gene and protein levels, respectively. Moreover, the prognoses of patients were analyzed. The positive expression rate (90.00%) of nm 23 in the normal laryngeal mucosal tissues was markedly higher than that in laryngeal cancer tissues (56.56%) (p<0.05). The expression of nm 23 proteins was correlated with the clinical staging of laryngeal cancer and the metastasis of lymph nodes (p<0.05). The expression of both nm 23 genes and proteins in the laryngeal cancer tissues were significantly lower than those in the normal laryngeal mucosal tissues (p<0.05). The survival rate of the positive nm 23 expression was substantially higher than that of the negative expression with a statistically significant difference (p<0.01). In conclusion, the expression of nm 23 proteins plays an important role in the development and metastasis of laryngeal cancer and may be taken as one of the indicators to evaluate the prognoses of such patients.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Zheng Z, Tian R and Wang P: Roles of KAI1 and nm23 in lymphangiogenesis and lymph metastasis of laryngeal squamous cell carcinoma. World J Surg Oncol. 15:2112017. View Article : Google Scholar : PubMed/NCBI

2 

Lovato A, Marioni G, Manzato E, Staffieri C, Giacomelli L, Ralli G, Staffieri A and Blandamura S: Elderly patients at higher risk of laryngeal carcinoma recurrence could be identified by a panel of two biomarkers (nm23-H1 and CD105) and pN+ status. Eur Arch Otorhinolaryngol. 272:3417–3424. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Lionello M, Blandamura S, Lovato A, Franchella S, Giacomelli L, Ottaviano G, Stellini E, Staffieri A and Marioni G: A high nuclear nm23-H1 expression is associated with a better prognosis in elderly patients with laryngeal carcinoma. Acta Otolaryngol. 133:874–880. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Du P, Xu B, Zhang D, Shao Y, Zheng X, Li X, Xiong Y, Wu C and Jiang J: Hierarchical investigating the predictive value of p53, COX2, EGFR, nm23 in the post-operative patients with colorectal carcinoma. Oncotarget. 8:954–966. 2017.PubMed/NCBI

5 

Perisa MM, Sarcevic B, Troselj KG, Grsic K, Sitic S and Seiwerth S: Expression of nm23-H1 and COX-2 in thyroid papillary carcinoma and microcarcinoma. Oncol Lett. 13:3547–3555. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Geng QQ, Li Y, Tang CH, Li EX, Wu YY and Zhang GJ: Expression and clinical significance of vascular endothelial growth factor-C and nm23-H1 in stage II and III colorectal carcinomas. Zhonghua Zhong Liu Za Zhi. 35:439–444. 2013.(In Chinese). PubMed/NCBI

7 

Radović S, Dorić M, Hukić A, Babić M, Kuskunović S and Spahović N: Immunohistochemical expression and significance of NM23 suppressor protein in primary gastric adenocarcinoma. Bosn J Basic Med Sci. 13:72–77. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Lionello M, Blandamura S, Agostini M, Staffieri C, Lovato A, Tealdo G, Favaretto N, Giacomelli L, Loreggian L, Staffieri A, et al: A prognostic role for Nm23-H1 in laryngeal carcinoma treated with postoperative radiotherapy: An introductory investigation. Eur Arch Otorhinolaryngol. 270:197–203. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Bozdogan O, Vargel I, Cavusoglu T, Karabulut AA, Karahan G, Sayar N, Atasoy P and Yulug IG: Metastasis suppressor proteins in cutaneous squamous cell carcinoma. Pathol Res Pract. 212:608–615. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Yuan C, Xu XH, Xu L, Sun M, Ni LH, Liu Y, Ran F, Wang XL, Chen Z, Zhang K, et al: Low expression of nm23-H1 associates with poor survival of nasopharyngeal carcinoma patients: A prisma-compliant meta-analysis. Medicine (Baltimore). 96:e71532017. View Article : Google Scholar : PubMed/NCBI

11 

Wang YF, Chang CJ, Chiu JH, Lin CP, Li WY, Chang SY, Chu PY, Tai SK and Chen YJ: NM23-H1 expression of head and neck squamous cell carcinoma in association with the response to cisplatin treatment. Oncotarget. 5:7392–7405. 2014.PubMed/NCBI

12 

Cubukcu E, Kanat O, Olmez Fatih O, Kabul S, Canhoroz M, Avci N, Deligonul A, Hartavi M, Cubukcu S, Olmez F, et al: Prognostic significance of estrogen receptor, progesterone receptor, HER2/neu, Ki-67, and nm23 expression in patients with invasive breast cancer. J BUON. 18:359–365. 2013.PubMed/NCBI

13 

Marioni G, Ottaviano G, Lionello M, Lora L, Lovato A, Staffieri C, Favaretto N, Giacomelli L, Stellini E, Staffieri A, et al: Nm23-H1 nuclear expression is associated with a more favourable prognosis in laryngeal carcinoma: Univariate and multivariate analysis. Histopathology. 61:1057–1064. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Fang M, Tao Y, Liu Z, Huang H, Lao M, Huang L and Zhu B: Meta-analysis of the relationship between NM23 expression to gastric cancer risk and clinical features. BioMed Res Int. 2017:80471832017. View Article : Google Scholar : PubMed/NCBI

15 

He F, York JP, Burroughs SG, Qin L, Xia J, Chen D, Quigley EM, Webb P, LeSage GD and Xia X: Recruited metastasis suppressor NM23-H2 attenuates expression and activity of peroxisome proliferator-activated receptor δ (PPARδ) in human cholangiocarcinoma. Dig Liver Dis. 47:62–67. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Han W, Zhang C, Cao FY, Cao F, Jiang L and Ding HZ: Prognostic and clinicopathological value of NM23 expression in patients with breast cancer: A systematic review and meta-analysis. Curr Probl Cancer. 41:80–93. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Tong Y, Yung LY and Wong YH: Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis. Cancer Lett. 361:207–217. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Fu JW and Chu XQ: Correlation between non-metastatic protein 23 expression and clinicopathological features of colorectal cancer in Asians. Genet Mol Res. 14:15597–15608. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Shahebrahimi K, Madani SH, Fazaeli AR, Khazaei S, Kanani M and Keshavarz A: Diagnostic value of CD56 and nm23 markers in papillary thyroid carcinoma. Indian J Pathol Microbiol. 56:2–5. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Yang T, Chen BZ, Li DF, Wang HM, Lin XS, Wei HF and Zeng YM: Reduced NM23 protein level correlates with worse clinicopathologic features in colorectal cancers: A meta-analysis of pooled data. Medicine (Baltimore). 95:e25892016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wei W, Wei X and Liang X: Correlation of nm 23 expression with pharyngeal cancer and patient prognoses Retraction in /10.3892/ol.2025.15061. Oncol Lett 16: 5667-5672, 2018.
APA
Wei, W., Wei, X., & Liang, X. (2018). Correlation of nm 23 expression with pharyngeal cancer and patient prognoses Retraction in /10.3892/ol.2025.15061. Oncology Letters, 16, 5667-5672. https://doi.org/10.3892/ol.2018.9375
MLA
Wei, W., Wei, X., Liang, X."Correlation of nm 23 expression with pharyngeal cancer and patient prognoses Retraction in /10.3892/ol.2025.15061". Oncology Letters 16.5 (2018): 5667-5672.
Chicago
Wei, W., Wei, X., Liang, X."Correlation of nm 23 expression with pharyngeal cancer and patient prognoses Retraction in /10.3892/ol.2025.15061". Oncology Letters 16, no. 5 (2018): 5667-5672. https://doi.org/10.3892/ol.2018.9375
Copy and paste a formatted citation
x
Spandidos Publications style
Wei W, Wei X and Liang X: Correlation of nm 23 expression with pharyngeal cancer and patient prognoses Retraction in /10.3892/ol.2025.15061. Oncol Lett 16: 5667-5672, 2018.
APA
Wei, W., Wei, X., & Liang, X. (2018). Correlation of nm 23 expression with pharyngeal cancer and patient prognoses Retraction in /10.3892/ol.2025.15061. Oncology Letters, 16, 5667-5672. https://doi.org/10.3892/ol.2018.9375
MLA
Wei, W., Wei, X., Liang, X."Correlation of nm 23 expression with pharyngeal cancer and patient prognoses Retraction in /10.3892/ol.2025.15061". Oncology Letters 16.5 (2018): 5667-5672.
Chicago
Wei, W., Wei, X., Liang, X."Correlation of nm 23 expression with pharyngeal cancer and patient prognoses Retraction in /10.3892/ol.2025.15061". Oncology Letters 16, no. 5 (2018): 5667-5672. https://doi.org/10.3892/ol.2018.9375
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team