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miR‑339‑5p inhibits lung adenocarcinoma invasion and migration by directly targeting BCL6

  • Authors:
    • Peng Li
    • Huaqing Liu
    • Yanmeng Li
    • Yan Wang
    • Lin Zhao
    • Hui Wang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China, The Third Department of Neurology, Zhangqiu People's Hospital, Jinan, Shandong 250200, P.R. China, Department of Laboratory Medicine, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China, Department of Public Health, Zhangqiu People's Hospital, Jinan, Shandong 250200, P.R. China, The Second Department of Respiratory Medicine, People's Hospital of Linyi, Linyi, Shandong 276003, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5785-5790
    |
    Published online on: August 31, 2018
       https://doi.org/10.3892/ol.2018.9376
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Abstract

Lung adenocarcinoma (LA) is a common non‑small cell lung cancer, but effective biomarkers to diagnose early LA are still lacking. Increasing evidence has indicated that the dysregulation of microRNAs (miRNAs) play crucial roles in LA progression. miR‑339‑5p has been recently confirmed to exert crucial functions in various cancers. Nevertheless, molecular mechanisms and effects of miR‑339‑5p on LA development still remain vague. In the present research, miR‑339‑5p expression was downregulated in human LA tissues. miR‑339‑5p overexpression in LA cells could remarkably suppress the LA cell invasion and migration. In addition, further studies indicated that miR‑339‑5p overexpression downregulated both the B‑cell lymphoma 6 (BCL6) mRNA and protein expressions by targeting the BCL6 3'‑UTR directly. Moreover, BCL6 knockdown could partially lessen the function of miR‑339‑5p in LA invasion and migration. In conclusion, the present data identified miR‑339‑5p as a novel LA suppressor which exerted its functions partly by negatively regulating BCL6.
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Copy and paste a formatted citation
Spandidos Publications style
Li P, Liu H, Li Y, Wang Y, Zhao L and Wang H: miR‑339‑5p inhibits lung adenocarcinoma invasion and migration by directly targeting BCL6. Oncol Lett 16: 5785-5790, 2018.
APA
Li, P., Liu, H., Li, Y., Wang, Y., Zhao, L., & Wang, H. (2018). miR‑339‑5p inhibits lung adenocarcinoma invasion and migration by directly targeting BCL6. Oncology Letters, 16, 5785-5790. https://doi.org/10.3892/ol.2018.9376
MLA
Li, P., Liu, H., Li, Y., Wang, Y., Zhao, L., Wang, H."miR‑339‑5p inhibits lung adenocarcinoma invasion and migration by directly targeting BCL6". Oncology Letters 16.5 (2018): 5785-5790.
Chicago
Li, P., Liu, H., Li, Y., Wang, Y., Zhao, L., Wang, H."miR‑339‑5p inhibits lung adenocarcinoma invasion and migration by directly targeting BCL6". Oncology Letters 16, no. 5 (2018): 5785-5790. https://doi.org/10.3892/ol.2018.9376
Copy and paste a formatted citation
x
Spandidos Publications style
Li P, Liu H, Li Y, Wang Y, Zhao L and Wang H: miR‑339‑5p inhibits lung adenocarcinoma invasion and migration by directly targeting BCL6. Oncol Lett 16: 5785-5790, 2018.
APA
Li, P., Liu, H., Li, Y., Wang, Y., Zhao, L., & Wang, H. (2018). miR‑339‑5p inhibits lung adenocarcinoma invasion and migration by directly targeting BCL6. Oncology Letters, 16, 5785-5790. https://doi.org/10.3892/ol.2018.9376
MLA
Li, P., Liu, H., Li, Y., Wang, Y., Zhao, L., Wang, H."miR‑339‑5p inhibits lung adenocarcinoma invasion and migration by directly targeting BCL6". Oncology Letters 16.5 (2018): 5785-5790.
Chicago
Li, P., Liu, H., Li, Y., Wang, Y., Zhao, L., Wang, H."miR‑339‑5p inhibits lung adenocarcinoma invasion and migration by directly targeting BCL6". Oncology Letters 16, no. 5 (2018): 5785-5790. https://doi.org/10.3892/ol.2018.9376
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