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Article

Effects of NOTCH1 signaling inhibitor γ‑secretase inhibitor II on growth of cancer stem cells

  • Authors:
    • Xiaodong Ding
    • Changqing Ding
    • Fei Wang
    • Wenshuai Deng
    • Mingming Yu
    • Qinghai Meng
    • Peng Sun
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China, Department of Neurosurgery, The Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, P.R. China, Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China
  • Pages: 6095-6099
    |
    Published online on: September 3, 2018
       https://doi.org/10.3892/ol.2018.9377
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Abstract

The present study aimed to observe the effect of the Notch1 signaling inhibitor γ‑secretase inhibitor II (GSI II) on the growth and differentiation of tumor cells. The tumor cell line U87 was grown in serum‑free media, and cell growth was evaluated using immunofluorescence. Single‑cell wall‑adherent growing conditions were prepared, GSI II was added, and the differentiation and growth of single tumor cells was evaluated. Immunofluorescence demonstrated positive results for the expression of Nestin and cluster of differentiation 133. The cell proliferation rate was reduced following the addition of GSI II (P<0.05). GSI II may significantly inhibit the proliferation and differentiation of U87 tumor stem cells.
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Copy and paste a formatted citation
Spandidos Publications style
Ding X, Ding C, Wang F, Deng W, Yu M, Meng Q and Sun P: Effects of NOTCH1 signaling inhibitor γ‑secretase inhibitor II on growth of cancer stem cells. Oncol Lett 16: 6095-6099, 2018.
APA
Ding, X., Ding, C., Wang, F., Deng, W., Yu, M., Meng, Q., & Sun, P. (2018). Effects of NOTCH1 signaling inhibitor γ‑secretase inhibitor II on growth of cancer stem cells. Oncology Letters, 16, 6095-6099. https://doi.org/10.3892/ol.2018.9377
MLA
Ding, X., Ding, C., Wang, F., Deng, W., Yu, M., Meng, Q., Sun, P."Effects of NOTCH1 signaling inhibitor γ‑secretase inhibitor II on growth of cancer stem cells". Oncology Letters 16.5 (2018): 6095-6099.
Chicago
Ding, X., Ding, C., Wang, F., Deng, W., Yu, M., Meng, Q., Sun, P."Effects of NOTCH1 signaling inhibitor γ‑secretase inhibitor II on growth of cancer stem cells". Oncology Letters 16, no. 5 (2018): 6095-6099. https://doi.org/10.3892/ol.2018.9377
Copy and paste a formatted citation
x
Spandidos Publications style
Ding X, Ding C, Wang F, Deng W, Yu M, Meng Q and Sun P: Effects of NOTCH1 signaling inhibitor γ‑secretase inhibitor II on growth of cancer stem cells. Oncol Lett 16: 6095-6099, 2018.
APA
Ding, X., Ding, C., Wang, F., Deng, W., Yu, M., Meng, Q., & Sun, P. (2018). Effects of NOTCH1 signaling inhibitor γ‑secretase inhibitor II on growth of cancer stem cells. Oncology Letters, 16, 6095-6099. https://doi.org/10.3892/ol.2018.9377
MLA
Ding, X., Ding, C., Wang, F., Deng, W., Yu, M., Meng, Q., Sun, P."Effects of NOTCH1 signaling inhibitor γ‑secretase inhibitor II on growth of cancer stem cells". Oncology Letters 16.5 (2018): 6095-6099.
Chicago
Ding, X., Ding, C., Wang, F., Deng, W., Yu, M., Meng, Q., Sun, P."Effects of NOTCH1 signaling inhibitor γ‑secretase inhibitor II on growth of cancer stem cells". Oncology Letters 16, no. 5 (2018): 6095-6099. https://doi.org/10.3892/ol.2018.9377
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