Effects of NOTCH1 signaling inhibitor γ‑secretase inhibitor II on growth of cancer stem cells

  • Authors:
    • Xiaodong Ding
    • Changqing Ding
    • Fei Wang
    • Wenshuai Deng
    • Mingming Yu
    • Qinghai Meng
    • Peng Sun
  • View Affiliations

  • Published online on: September 3, 2018     https://doi.org/10.3892/ol.2018.9377
  • Pages: 6095-6099
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study aimed to observe the effect of the Notch1 signaling inhibitor γ‑secretase inhibitor II (GSI II) on the growth and differentiation of tumor cells. The tumor cell line U87 was grown in serum‑free media, and cell growth was evaluated using immunofluorescence. Single‑cell wall‑adherent growing conditions were prepared, GSI II was added, and the differentiation and growth of single tumor cells was evaluated. Immunofluorescence demonstrated positive results for the expression of Nestin and cluster of differentiation 133. The cell proliferation rate was reduced following the addition of GSI II (P<0.05). GSI II may significantly inhibit the proliferation and differentiation of U87 tumor stem cells.
View Figures
View References

Related Articles

Journal Cover

November-2018
Volume 16 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ding X, Ding C, Wang F, Deng W, Yu M, Meng Q and Sun P: Effects of NOTCH1 signaling inhibitor γ‑secretase inhibitor II on growth of cancer stem cells. Oncol Lett 16: 6095-6099, 2018
APA
Ding, X., Ding, C., Wang, F., Deng, W., Yu, M., Meng, Q., & Sun, P. (2018). Effects of NOTCH1 signaling inhibitor γ‑secretase inhibitor II on growth of cancer stem cells. Oncology Letters, 16, 6095-6099. https://doi.org/10.3892/ol.2018.9377
MLA
Ding, X., Ding, C., Wang, F., Deng, W., Yu, M., Meng, Q., Sun, P."Effects of NOTCH1 signaling inhibitor γ‑secretase inhibitor II on growth of cancer stem cells". Oncology Letters 16.5 (2018): 6095-6099.
Chicago
Ding, X., Ding, C., Wang, F., Deng, W., Yu, M., Meng, Q., Sun, P."Effects of NOTCH1 signaling inhibitor γ‑secretase inhibitor II on growth of cancer stem cells". Oncology Letters 16, no. 5 (2018): 6095-6099. https://doi.org/10.3892/ol.2018.9377