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Article Open Access

Upregulation of stem cell markers ALDH1A1 and OCT4 as potential biomarkers for the early detection of cervical carcinoma

  • Authors:
    • Wuniqiemu Tulake
    • Reziwanguli Yuemaier
    • Lei Sheng
    • Mingfang Ru
    • Dilare Lidifu
    • Abulizi Abudula
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China, Department of Clinical Research, People's Hospital of Xinjiang Uighur Autonomous Region, Urumqi, Xinjiang 830001, P.R. China, Key Laboratory of The Chinese Ministry of Education and Xinjiang Uighur Autonomous Region for High‑Incident Diseases in Uighur Ethnic Population, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China, Department of Gynecology, Third Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China
    Copyright: © Tulake et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5525-5534
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    Published online on: September 3, 2018
       https://doi.org/10.3892/ol.2018.9381
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Abstract

Previous studies have reported the upregulation of stem cell biomarkers that are associated with tumorigenesis, in particular with cancer infiltration, recurrence and metastasis. Infection by human papilloma virus (HPV) is the main etiopathological factor of cervical carcinogenesis, but the expression of stem cell markers in cervical carcinoma and HPV infection have yet to be investigated so far. A total of 94 cases of fresh cervical tissues, 116 cases of paraffin‑embedded cervical specimens and 72 cases of peripheral blood samples were collected from Uighur women who were either diagnosed with cervical squamous cell carcinoma (SCC) or cervical intraepithelial neoplasia (CIN) II‑III, or from healthy subjects (negative controls, NC). HPV infection was detected in tissue DNA by polymerase chain reaction (PCR) with a HPV genotyping kit. The mRNA expression levels of aldehyde dehydrogenase 1 family member A1 (ALDH1A1), nanog homeobox (NANOG), POU class 5 homeobox 1 (OCT4), SRY‑box 2 (SOX2) and twist family BHLH transcription factor 1 (Twist1) were determined using reverse transcription‑quantitative PCR (RT‑qPCR). Histological analysis was performed in order to examine the protein expression of ALDH1A1 and OCT4 in paraffin‑embedded tissue specimens by immunohistochemical staining and the plasma levels of those two proteins was measured by ELISA. RT‑qPCR analysis indicated a significant increase in the mRNA expression of ALDH1A1 and OCT4 in CIN II‑III and SCC tissue specimens compared with NC (P<0.05). Although the expression levels of NANOG, SOX2 and Twist1 were significantly higher in SCC compared with NC (P<0.05), no significant difference was revealed in CIN II‑III tissues compared with SCC or NC (P>0.05). Subsequent analysis by immunohistochemistry staining confirmed that the upregulation of ALDH1A1 and OCT4 was also significantly increased in SCC and CIN II‑III compared with controls at the protein level. Notably, ELISA analysis detected significantly higher levels of ALDH1A1 and OCT4 in the peripheral blood (plasma) of patients with SCC compared with healthy subjects. The upregulation of stem cell markers ALDH1A1 and OCT4 in cervical carcinoma and its precursor lesions, in particular in the peripheral blood, indicates that ALDH1A1 and OCT4 may serve as biomarkers for the early detection of cervical carcinoma or for the monitoring of treatment of patients.
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View References

1 

Meacham CE and Morrison SJ: Tumour heterogeneity and cancer cell plasticity. Nature. 501:328–337. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Islam F, Gopalan V, Smith RA and Lam AK: Translational potential of cancer stem cells: A review of the detection of cancer stem cells and their roles in cancer recurrence and cancer treatment. Exp Cell Res. 335:135–147. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Ferenczy A and Franco E: Persistent human papillomavirus infection and cervical neoplasia. Lancet Oncol. 3:11–16. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Tindle RW: Immune evasion in human papillomavirus-associated cervical cancer. Nat Rev Cancer. 2:59–65. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Chhabra R: Cervical cancer stem cells: Opportunities and challenges. J Cancer Res Clin Oncol. 141:1889–1897. 2015. View Article : Google Scholar : PubMed/NCBI

6 

López J, Valdez-Morales FJ, Benitez-Bribiesca L, Cerbón M and Carrancá AG: Normal and cancer stem cells of the human female reproductive system. Reprod Biol Endocrinol. 11:532013. View Article : Google Scholar : PubMed/NCBI

7 

Herfs M, Yamamoto Y, Laury A, Wang X, Nucci MR, McLaughlin-Drubin ME, Münger K, Feldman S, McKeon FD, Xian W and Crum CP: A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer. Proc Natl Acad Sci USA. 109:10516–10521. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Letian T and Tianyu Z: Cellular receptor binding and entry of human papillomavirus. Virol J. 7:22010. View Article : Google Scholar : PubMed/NCBI

9 

Pyeon D, Pearce SM, Lank SM, Ahlquist P and Lambert PF: Establishment of human papillomavirus infection requires cell cycle progression. PLoS Pathog. 5:e10003182009. View Article : Google Scholar : PubMed/NCBI

10 

Quade BJ, Yang A, Wang Y, Sun D, Park J, Sheets EE, Cviko A, Federschneider JM, Peters R, McKeon FD and Crum CP: Expression of the p53 homologue p63 in early cervical neoplasia. Gynecol Oncol. 80:24–29. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Sell S: On the stem cell origin of cancer. Am J Pathol. 176:2584–2494. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Martens JE, Arends J, Van der Linden PJ, De Boer BA and Helmerhorst TJ: Cytokeratin 17 and p63 are markers of the HPV target cell, the cervical stem cell. Anticancer Res. 24:771–775. 2004.PubMed/NCBI

13 

Mighty KK and Laimins LA: p63 is necessary for the activation of human papillomavirus late viral functions upon epithelial differentiation. J Virol. 85:8863–8869. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Wang Z, Oron E, Nelson B, Razis S and Ivanova N: Distinct lineage specification roles for NANOG, OCT4 and SOX2 in human embryonic stem cells. Cell Stem Cell. 10:440–454. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Hattori N, Imao Y, Nishino K, Hattori N, Ohgane J, Yagi S, Tanaka S and Shiota K: Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells. Genes Cells. 12:387–396. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Ye F, Zhou C, Cheng Q, Shen J and Chen H: Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells. BMC cancer. 8:1082008. View Article : Google Scholar : PubMed/NCBI

17 

Liu D, Zhou P, Zhang L, Wu G, Zheng Y and He F: Differential expression of Oct4 in HPV-positive and HPV-negative cervical cancer cells is not regulated by DNA methyltransferase 3A. Tumour Biol. 32:941–950. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Li SW, Wu XL, Dong CL, Xie XY, Wu JF and Zhang X: The differential expression of OCT4 isoforms in cervical carcinoma. PLoS One. 10:e01180332015. View Article : Google Scholar : PubMed/NCBI

19 

Yao T, Chen Q, Zhang B, Zhou H and Lin Z: The expression of ALDH1 in cervical carcinoma. Med Sci Monit. 17:HY21–HY26. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Rao QX, Yao TT, Zhang BZ, Lin RC, Chen ZL, Zhou H, Wang LJ, Lu HW, Chen Q, Di N and Lin ZQ: Expression and functional role of ALDH1 in cervical carcinoma cells. Asian Pac J Cancer Prev. 13:1325–1331. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Liu SY and Zheng PS: High aldehyde dehydrogenase activity identifies cancer stem cells in human cervical cancer. Oncotarget. 4:2462–2475. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Li J and Zhou BP: Activation of beta-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters. BMC Cancer. 11:492011. View Article : Google Scholar : PubMed/NCBI

23 

Lin J, Liu X and Ding D: Evidence for epithelial-mesenchymal transition in cancer stem-like cells derived from carcinoma cell lines of the cervix uteri. Int J Clin Exp Pathol. 8:847–855. 2015.PubMed/NCBI

24 

Saslow D, Runowicz CD, Solomon D, Moscicki AB, Smith RA, Eyre HJ and Cohen C: American Cancer, Society: American Cancer Society guideline for the early detection of cervical neoplasia and cancer. CA Cancer J Clin. 52:342–362. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Pecorelli S, Benedet JL, Creasman WT and Shepherd JH: FIGO staging of gynecologic cancer. 1994–1997 FIGO Committee on Gynecologic Oncology. International Federation of Gynecology and Obstetrics. Int J Gynaecol Obstet. 65:243–249. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Mason DY: Immunocytochemical analysis of human tissueOxford Textbook of Pathology. Oxford University Press; Oxford: 2. pp. 2275–2284. 1992

28 

Ping YF and Bian XW: Consice review: Contribution of cancer stem cells to neovascularization. Stem Cells. 29:888–894. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Facompre N, Nakagawa H, Herlyn M and Basu D: Stem-like cells and therapy resistance in squamous cell carcinomas. Adv Pharmacol. 65:235–265. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Patel P and Chen EI: Cancer stem cells, tumor dormancy, and metastasis. Front Endocrinol (Lausanne). 3:1252012.PubMed/NCBI

31 

Andrews TE, Wang D and Harki DA: Cell surface markers of cancer stem cells: Diagnostic macromolecules and targets for drug delivery. Drug Deliv Transl Res. 3:121–142. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Xia P: Surface markers of cancer stem cells in solid tumors. Curr Stem Cell Res Ther. 9:102–111. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Allegra A, Alonci A, Penna G, Innao V, Gerace D, Rotondo F and Musolino C: The cancer stem cell hypothesis: A guide to potential molecular targets. Cancer Invest. 32:470–495. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Sladek NE: Human aldehyde dehydrogenases: Potential pathological, pharmacological, and toxicological impact. J Biochem Mol Toxicol. 17:7–23. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Chute JP, Muramoto GG, Whitesides J, Colvin M, Safi R, Chao NJ and McDonnell DP: Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. Proc Natl Acad Sci USA. 103:11707–11712. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Marcato P, Dean CA, Giacomantonio CA and Lee PW: Aldehyde dehydrogenase: Its role as a cancer stem cell marker comes down to the specific isoform. Cell Cycle. 10:1378–1384. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Tomita H, Tanaka K, Tanaka T and Hara A: Aldehyde dehydrogenase 1A1 in stem cells and cancer. Oncotarget. 7:11018–11032. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Le Magnen C, Bubendorf L, Rentsch CA, Mengus C, Gsponer J, Zellweger T, Rieken M, Thalmann GN, Cecchini MG, Germann M, et al: Characterization and clinical relevance of ALDHbright populations in prostate cancer. Clin Cancer Res. 19:5361–5371. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Kurashige T, Shimamura M, Yasui K, Mitsutake N, Matsuse M, Nakashima M, Minami S, Eguchi S and Nagayama Y: Studies on the expression of aldehyde dehydrogenase in normal and cancerous tissues of thyroids. Horm Metab Res. 47:194–199. 2015.PubMed/NCBI

40 

Wu S, Xue W, Huang X, Yu X, Luo M, Huang Y, Liu Y, Bi Z, Qiu X and Bai S: Distinct prognostic values of ALDH1 isoenzymes in breast cancer. Tumour Biol. 36:2421–2426. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Patel M, Lu L, Zander DS, Sreerama L, Coco D and Moreb JS: ALDH1A1 and ALDH3A1 expression in lung cancers: Correlation with histologic type and potential precursors. Lung Cancer. 59:340–349. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Hou T, Zhang W, Tong C, Kazobinka G, Huang X, Huang Y and Zhang Y: Putative stem cell markers in cervical squamous cell carcinoma are correlated with poor clinical outcome. BMC Cancer. 15:7852015. View Article : Google Scholar : PubMed/NCBI

43 

Yao T, Wu Z, Liu Y, Rao Q and Lin Z: Aldehyde dehydrogenase 1 (ALDH1) positivity correlates with poor prognosis in cervical cancer. J Int Med Res. 42:1038–1042. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Xie Q, Liang J, Rao Q, Xie X, Li R, Liu Y, Zhou H, Han J, Yao T and Lin Z: Aldehyde dehydrogenase 1 expression predicts chemoresistance and poor clinical outcomes in patients with locally advanced cervical cancer treated with neoadjuvant chemotherapy prior to radical hysterectomy. Ann Surg Oncol. 23:163–170. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, Wong E, Orlov YL, Zhang W, Jiang J, et al: Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell. 133:1106–1117. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Kim J, Chu J, Shen X, Wang J and Orkin SH: An extended transcriptional network for pluripotency of embryonic stem cells. Cell. 132:1049–1061. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Zeineddine D, Hammoud AA, Mortada M and Boeuf H: The Oct4 protein: More than a magic stemness marker. Am J Stem Cells. 3:74–82. 2014.PubMed/NCBI

48 

Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, et al: Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 122:947–956. 2005. View Article : Google Scholar : PubMed/NCBI

49 

Rizzino A: Concise review: The Sox2-Oct4 connection: Critical players in a much larger interdependent network integrated at multiple levels. Stem Cells. 31:1033–1039. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Liedtke S, Stephan M and Kögler G: Oct4 expression revisited: Potential pitfalls for data misinterpretation in stem cell research. Biol Chem. 389:845–850. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Wang YJ and Herlyn M: The emerging roles of Oct4 in tumor-initiating cells. Am J Physiol Cell Physiol. 309:C709–C718. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Wang YD, Cai N, Wu XL, Cao HZ, Xie LL and Zheng PS: OCT4 promotes tumorigenesis and inhibits apoptosis of cervical cancer cells by miR-125b/BAK1 pathway. Cell Death Dis. 4:e7602013. View Article : Google Scholar : PubMed/NCBI

53 

Echelman D and Feldman S: Management of cervical precancers: a global perspective. Hematol Oncol Clin North Am. 26:31–44. 2012. View Article : Google Scholar : PubMed/NCBI

54 

Kim BW, Cho H, Choi CH, Ylaya K, Chung JY, Kim JH and Hewitt SM: Clinical significance of OCT4 and SOX2 protein expression in cervical cancer. BMC Cancer. 15:10152015. View Article : Google Scholar : PubMed/NCBI

55 

Liu D, Zhou P, Zhang L, Zheng Y and He F: HPV16 activates the promoter of Oct4 gene by sequestering HDAC1 from repressor complex to target it to proteasomal degradation. Med Hypotheses. 79:531–534. 2012. View Article : Google Scholar : PubMed/NCBI

56 

Tyagi A, Vishnoi K, Mahata S, Verma G, Srivastava Y, Masaldan S, Roy BG, Bharti AC and Das BC: Cervical cancer stem cells selectively overexpress HPV oncoprotein E6 that controls stemness and self-renewal through upregulation of HES1. Clin Cancer Res. 22:4170–4184. 2016. View Article : Google Scholar : PubMed/NCBI

57 

Yang MH, Imrali A and Heeschen C: Circulating cancer stem cells: The importance to select. Clin Cancer Res. 27:437–449. 2015.

58 

Cao YT, Li JH, Wang YT, Fu YW and Xu J: Serum ALDH1A1 is a tumor marker for the diagnosis of non-small cell lung cancer. Tumori. 100:214–218. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Sladek NE, Kollander R, Sreerama L and Kiang DT: Cellular levels of aldehyde dehydrogenases (ALDH1A1 and ALDH3A1) as predictors of therapeutic responses to cyclophosphamide-based chemotherapy of breast cancer: A retrospective study. Rational individualization of oxazaphosphorine-based cancer chemotherapeutic regimens. Cancer Chemother Pharmacol. 49:309–321. 2002. View Article : Google Scholar : PubMed/NCBI

60 

Chang TS, Wu YC, Chi CC, Su WC, Chang PJ, Lee KF, Tung TH, Wang J, Liu JJ, Tung SY, et al: Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression. Clin Cancer Res. 21:201–210. 2015. View Article : Google Scholar : PubMed/NCBI

61 

Bobryshev YV, Orekhov AN and Chistiakov DA: Vascular stem/progenitor cells: Current status of the problem. Cell Tissue Res. 362:1–7. 2015. View Article : Google Scholar : PubMed/NCBI

62 

Krenning G, Barauna VG, Krieger JE, Harmsen MC and Moonen JR: Endothelial plasticity: Shifting phenotypes through force feedback. Stem Cells Int. 2016:97629592016. View Article : Google Scholar : PubMed/NCBI

63 

Minhajat R, Nilasari D and Bakri S: The role of endothelial progenitor cell in cardiovascular disease risk factors. Acta Med Indones. 47:340–347. 2015.PubMed/NCBI

64 

Gu W, Hong X, Potter C, Qu A and Xu Q: Mesenchymal stem cells and vascular regeneration. Microcirculation. 24:2017.doi: 10.1111/micc.12324. View Article : Google Scholar : PubMed/NCBI

65 

Sherman SE, Kuljanin M, Cooper TT, Putman DM, Lajoie GA and Hess DA: High aldehyde dehydrogenase activity identifies a subset of human mesenchymal stromal cells with vascular regenerative potential. Stem Cells. 35:1542–1553. 2017. View Article : Google Scholar : PubMed/NCBI

66 

Constantinescu S: Stemness, fusion and renewal of hematopoietic and embryonic stem cells. J Cell Mol Med. 7:103–112. 2003. View Article : Google Scholar : PubMed/NCBI

67 

Hattori N, Imao Y, Nishino K, Hattori N, Ohgane J, Yagi S, Tanaka S and Shiota K: Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells. Genes Cells. 12:387–396. 2007. View Article : Google Scholar : PubMed/NCBI

68 

Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A and Weinberg RA: An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet. 40:499–507. 2008. View Article : Google Scholar : PubMed/NCBI

69 

Suzuke L, Peng YH, Zhou K, et al: The analysis of pathogenetic tendency of cervical cancer in various ethnic women in Xinjiang. J Xinjiang Med Univ. 29:569–571. 2006.(In Chinese).

70 

Abudoukadeer A, Niyazi M, Aikula A, Kamilijian M, Sulaiman X, Mutailipu A and Abudula A: Association of EBV and HPV co-infection with the development of cervical cancer in ethnic Uyghur women. Eur J Gynaecol Oncol. 36:546–550. 2015.PubMed/NCBI

71 

Zhang GQ, LIU KJ, Lai XJ, et al: Distribution of malignant tumor patients in hospital from 1989 to 2002 in the Affiliated Tumor Hospital of Xinjiang Medical University. J Xinjiang Med Univ. 26:393–395. 2003.(In Chinese).

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Copy and paste a formatted citation
Spandidos Publications style
Tulake W, Yuemaier R, Sheng L, Ru M, Lidifu D and Abudula A: Upregulation of stem cell markers ALDH1A1 and OCT4 as potential biomarkers for the early detection of cervical carcinoma. Oncol Lett 16: 5525-5534, 2018.
APA
Tulake, W., Yuemaier, R., Sheng, L., Ru, M., Lidifu, D., & Abudula, A. (2018). Upregulation of stem cell markers ALDH1A1 and OCT4 as potential biomarkers for the early detection of cervical carcinoma. Oncology Letters, 16, 5525-5534. https://doi.org/10.3892/ol.2018.9381
MLA
Tulake, W., Yuemaier, R., Sheng, L., Ru, M., Lidifu, D., Abudula, A."Upregulation of stem cell markers ALDH1A1 and OCT4 as potential biomarkers for the early detection of cervical carcinoma". Oncology Letters 16.5 (2018): 5525-5534.
Chicago
Tulake, W., Yuemaier, R., Sheng, L., Ru, M., Lidifu, D., Abudula, A."Upregulation of stem cell markers ALDH1A1 and OCT4 as potential biomarkers for the early detection of cervical carcinoma". Oncology Letters 16, no. 5 (2018): 5525-5534. https://doi.org/10.3892/ol.2018.9381
Copy and paste a formatted citation
x
Spandidos Publications style
Tulake W, Yuemaier R, Sheng L, Ru M, Lidifu D and Abudula A: Upregulation of stem cell markers ALDH1A1 and OCT4 as potential biomarkers for the early detection of cervical carcinoma. Oncol Lett 16: 5525-5534, 2018.
APA
Tulake, W., Yuemaier, R., Sheng, L., Ru, M., Lidifu, D., & Abudula, A. (2018). Upregulation of stem cell markers ALDH1A1 and OCT4 as potential biomarkers for the early detection of cervical carcinoma. Oncology Letters, 16, 5525-5534. https://doi.org/10.3892/ol.2018.9381
MLA
Tulake, W., Yuemaier, R., Sheng, L., Ru, M., Lidifu, D., Abudula, A."Upregulation of stem cell markers ALDH1A1 and OCT4 as potential biomarkers for the early detection of cervical carcinoma". Oncology Letters 16.5 (2018): 5525-5534.
Chicago
Tulake, W., Yuemaier, R., Sheng, L., Ru, M., Lidifu, D., Abudula, A."Upregulation of stem cell markers ALDH1A1 and OCT4 as potential biomarkers for the early detection of cervical carcinoma". Oncology Letters 16, no. 5 (2018): 5525-5534. https://doi.org/10.3892/ol.2018.9381
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