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Expression of TRPM8 in human reactive lymphoid tissues and mature B‑cell neoplasms

  • Authors:
    • Akinori Hirai
    • Naing Ye Aung
    • Rintaro Ohe
    • Akiko Nishida
    • Tomoya Kato
    • Hongxue Meng
    • Kenichi Ishizawa
    • Junichi Fujii
    • Mitsunori Yamakawa
  • View Affiliations / Copyright

    Affiliations: Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Yamagata 990‑9585, Japan, Division of Pathology, Nihonkai General Hospital, Sakata, Yamagata 998‑8501, Japan, Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Yamagata 990‑9585, Japan, Department of Biochemistry and Molecular Biology, Yamagata University Faculty of Medicine, Yamagata, Yamagata 990‑9585, Japan
    Copyright: © Hirai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5930-5938
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    Published online on: September 3, 2018
       https://doi.org/10.3892/ol.2018.9386
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Abstract

Transient receptor potential melastatin 8 (TRPM8) is a member of the transient receptor potential superfamily of Ca2+ channels. The aim of the present study was to clarify TRPM8 expression in reactive lymphoid tissues and mature B‑cell neoplasms. Reactive and neoplastic lymphoid tissues were used to evaluate TRPM8 expression by immunohistochemistry and reverse transcription‑polymerase chain reaction (RT‑PCR). TRPM8+ cells were frequently detected in the follicular light zone and marginal zone of reactive lymphoid tissues. Double immunostaining revealed that TRPM8+ cells co‑expressed cluster of differentiation (CD) 38, CD79a, CD138, interferon regulatory factor 4/melanoma associated antigen (mutated) 1, B cell CLL/lymphoma 6 and transmembrane activator and CAML interactor. TRPM8+ neoplastic cells were frequently detected in plasma cell myeloma. The positive band of TRPM8 mRNA was confirmed by RT‑PCR in cases of myeloma. The present study is, to the best of our knowledge, the first to demonstrate the expression of TRPM8 in reactive lymphoid tissues and mature B‑cell neoplasms, revealing that TRPM8 is frequently expressed in pre‑plasmablasts, plasmablasts, plasma cells and mature B‑cell lymphomas that are likely to differentiate into plasma cells.
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Copy and paste a formatted citation
Spandidos Publications style
Hirai A, Aung NY, Ohe R, Nishida A, Kato T, Meng H, Ishizawa K, Fujii J and Yamakawa M: Expression of TRPM8 in human reactive lymphoid tissues and mature B‑cell neoplasms. Oncol Lett 16: 5930-5938, 2018.
APA
Hirai, A., Aung, N.Y., Ohe, R., Nishida, A., Kato, T., Meng, H. ... Yamakawa, M. (2018). Expression of TRPM8 in human reactive lymphoid tissues and mature B‑cell neoplasms. Oncology Letters, 16, 5930-5938. https://doi.org/10.3892/ol.2018.9386
MLA
Hirai, A., Aung, N. Y., Ohe, R., Nishida, A., Kato, T., Meng, H., Ishizawa, K., Fujii, J., Yamakawa, M."Expression of TRPM8 in human reactive lymphoid tissues and mature B‑cell neoplasms". Oncology Letters 16.5 (2018): 5930-5938.
Chicago
Hirai, A., Aung, N. Y., Ohe, R., Nishida, A., Kato, T., Meng, H., Ishizawa, K., Fujii, J., Yamakawa, M."Expression of TRPM8 in human reactive lymphoid tissues and mature B‑cell neoplasms". Oncology Letters 16, no. 5 (2018): 5930-5938. https://doi.org/10.3892/ol.2018.9386
Copy and paste a formatted citation
x
Spandidos Publications style
Hirai A, Aung NY, Ohe R, Nishida A, Kato T, Meng H, Ishizawa K, Fujii J and Yamakawa M: Expression of TRPM8 in human reactive lymphoid tissues and mature B‑cell neoplasms. Oncol Lett 16: 5930-5938, 2018.
APA
Hirai, A., Aung, N.Y., Ohe, R., Nishida, A., Kato, T., Meng, H. ... Yamakawa, M. (2018). Expression of TRPM8 in human reactive lymphoid tissues and mature B‑cell neoplasms. Oncology Letters, 16, 5930-5938. https://doi.org/10.3892/ol.2018.9386
MLA
Hirai, A., Aung, N. Y., Ohe, R., Nishida, A., Kato, T., Meng, H., Ishizawa, K., Fujii, J., Yamakawa, M."Expression of TRPM8 in human reactive lymphoid tissues and mature B‑cell neoplasms". Oncology Letters 16.5 (2018): 5930-5938.
Chicago
Hirai, A., Aung, N. Y., Ohe, R., Nishida, A., Kato, T., Meng, H., Ishizawa, K., Fujii, J., Yamakawa, M."Expression of TRPM8 in human reactive lymphoid tissues and mature B‑cell neoplasms". Oncology Letters 16, no. 5 (2018): 5930-5938. https://doi.org/10.3892/ol.2018.9386
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