Open Access

Gastric cancer initially presenting as bone metastasis: Two case reports and a literature review

  • Authors:
    • Daisuke Gomi
    • Toshirou Fukushima
    • Takashi Kobayashi
    • Nodoka Sekiguchi
    • Akiyuki Sakamoto
    • Keiko Mamiya
    • Tomonobu Koizumi
  • View Affiliations

  • Published online on: September 4, 2018     https://doi.org/10.3892/ol.2018.9393
  • Pages: 5863-5867
  • Copyright: © Gomi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer frequently spreads to the regional lymph nodes, liver and lungs following surgery or late in the clinical course. However, an initial clinical presentation of bone metastasis in gastric cancer patients is relatively rare. The current study presents two cases of gastric cancer diffusely metastasized to the spinal vertebrae and with a single metastasis to the trapezium, respectively. The initial presentations were an increased alkaline phosphatase level without any symptoms associated with bone metastasis in the first case and a swelling in the right carpometacarpal joint of the thumb in the second case. These clinical manifestations are also extremely rare in gastric cancer with bone metastasis. The study emphasizes that a diagnosis of gastric cancer should be considered in patients with increased alkaline phosphatase without clinical symptoms or with a single bone metastasis.
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November-2018
Volume 16 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Gomi D, Fukushima T, Kobayashi T, Sekiguchi N, Sakamoto A, Mamiya K and Koizumi T: Gastric cancer initially presenting as bone metastasis: Two case reports and a literature review. Oncol Lett 16: 5863-5867, 2018
APA
Gomi, D., Fukushima, T., Kobayashi, T., Sekiguchi, N., Sakamoto, A., Mamiya, K., & Koizumi, T. (2018). Gastric cancer initially presenting as bone metastasis: Two case reports and a literature review. Oncology Letters, 16, 5863-5867. https://doi.org/10.3892/ol.2018.9393
MLA
Gomi, D., Fukushima, T., Kobayashi, T., Sekiguchi, N., Sakamoto, A., Mamiya, K., Koizumi, T."Gastric cancer initially presenting as bone metastasis: Two case reports and a literature review". Oncology Letters 16.5 (2018): 5863-5867.
Chicago
Gomi, D., Fukushima, T., Kobayashi, T., Sekiguchi, N., Sakamoto, A., Mamiya, K., Koizumi, T."Gastric cancer initially presenting as bone metastasis: Two case reports and a literature review". Oncology Letters 16, no. 5 (2018): 5863-5867. https://doi.org/10.3892/ol.2018.9393