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Poly(ADP‑ribose) polymerase‑3 overexpression is associated with poor prognosis in patients with breast cancer following chemotherapy

  • Authors:
    • Zhiguo Song
    • Yong Wang
    • Qinghuan Xia
    • Zhaojin Yu
    • Lin Zhao
    • Huizhe Wu
    • Mingli Sun
    • Zhangguo Chai
    • Ping Hou
    • Xiaoqiang Geng
    • Wensi Liu
    • Minjie Wei
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning 110122, P.R. China, Department of General Practice, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Deparment of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning 110122, P.R. China, Outpatient Department, Shenyang Artillery Academy, Shenyang, Liaoning 110867, P.R. China, Liaoning Blood Center, Shenyang, Liaoning 110044, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5621-5630
    |
    Published online on: September 5, 2018
       https://doi.org/10.3892/ol.2018.9398
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Abstract

Double strand breaks induced by genotoxic agents, if inappropriately repaired, will cause cell death or induce cancer. Poly(ADP‑ribose) polymerase‑3 (PARP‑3) serves a role in double strand break repair, and may be involved in tumorigenesis. To the best of our knowledge, the role of PARP‑3 in breast cancer has not yet been examined. In the present study, the expression of PARP‑3 was investigated in 493 breast cancer samples and 54 tumor‑adjacent control samples using tissue‑microarray‑based immunohistochemistry. PARP‑3 expression was higher in breast cancer samples compared with control samples. PARP‑3 overexpression was significantly associated with histological grade II‑III (P=0.012). In addition, PARP‑3 overexpression was significantly associated with shorter disease‑free survival (DFS; P=0.027) time and exhibited a tendency toward shorter overall survival (OS; P=0.183) time in patients with breast cancer compared with patients with lower PARP‑3 expression, particularly in BRCA1‑positive patients (P=0.004 for disease‑free survival and P=0.095 for OS). Multivariate Cox regression analysis indicated that PARP‑3 was an independent prognostic factor in patients with breast cancer. Furthermore, it was revealed that PARP‑3 overexpression was associated with shorter survival time in patients with cyclophosphamide/doxorubicin or epirubicin/5‑fluorouracil (CAF/CEF) chemotherapy compared with low PARP‑3 expression, but not in patients with CAF/CEF + docetaxel chemotherapy. The present study suggested that PARP‑3 may be used as a biomarker for predicting the clinical outcome of patients receiving chemotherapy, and targeting PARP‑3 may be a potential therapeutic strategy for the treatment of breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Song Z, Wang Y, Xia Q, Yu Z, Zhao L, Wu H, Sun M, Chai Z, Hou P, Geng X, Geng X, et al: Poly(ADP‑ribose) polymerase‑3 overexpression is associated with poor prognosis in patients with breast cancer following chemotherapy. Oncol Lett 16: 5621-5630, 2018.
APA
Song, Z., Wang, Y., Xia, Q., Yu, Z., Zhao, L., Wu, H. ... Wei, M. (2018). Poly(ADP‑ribose) polymerase‑3 overexpression is associated with poor prognosis in patients with breast cancer following chemotherapy. Oncology Letters, 16, 5621-5630. https://doi.org/10.3892/ol.2018.9398
MLA
Song, Z., Wang, Y., Xia, Q., Yu, Z., Zhao, L., Wu, H., Sun, M., Chai, Z., Hou, P., Geng, X., Liu, W., Wei, M."Poly(ADP‑ribose) polymerase‑3 overexpression is associated with poor prognosis in patients with breast cancer following chemotherapy". Oncology Letters 16.5 (2018): 5621-5630.
Chicago
Song, Z., Wang, Y., Xia, Q., Yu, Z., Zhao, L., Wu, H., Sun, M., Chai, Z., Hou, P., Geng, X., Liu, W., Wei, M."Poly(ADP‑ribose) polymerase‑3 overexpression is associated with poor prognosis in patients with breast cancer following chemotherapy". Oncology Letters 16, no. 5 (2018): 5621-5630. https://doi.org/10.3892/ol.2018.9398
Copy and paste a formatted citation
x
Spandidos Publications style
Song Z, Wang Y, Xia Q, Yu Z, Zhao L, Wu H, Sun M, Chai Z, Hou P, Geng X, Geng X, et al: Poly(ADP‑ribose) polymerase‑3 overexpression is associated with poor prognosis in patients with breast cancer following chemotherapy. Oncol Lett 16: 5621-5630, 2018.
APA
Song, Z., Wang, Y., Xia, Q., Yu, Z., Zhao, L., Wu, H. ... Wei, M. (2018). Poly(ADP‑ribose) polymerase‑3 overexpression is associated with poor prognosis in patients with breast cancer following chemotherapy. Oncology Letters, 16, 5621-5630. https://doi.org/10.3892/ol.2018.9398
MLA
Song, Z., Wang, Y., Xia, Q., Yu, Z., Zhao, L., Wu, H., Sun, M., Chai, Z., Hou, P., Geng, X., Liu, W., Wei, M."Poly(ADP‑ribose) polymerase‑3 overexpression is associated with poor prognosis in patients with breast cancer following chemotherapy". Oncology Letters 16.5 (2018): 5621-5630.
Chicago
Song, Z., Wang, Y., Xia, Q., Yu, Z., Zhao, L., Wu, H., Sun, M., Chai, Z., Hou, P., Geng, X., Liu, W., Wei, M."Poly(ADP‑ribose) polymerase‑3 overexpression is associated with poor prognosis in patients with breast cancer following chemotherapy". Oncology Letters 16, no. 5 (2018): 5621-5630. https://doi.org/10.3892/ol.2018.9398
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