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Article

EPA significantly improves anti‑EGFR targeted therapy by regulating miR‑378 expression in colorectal cancer

  • Authors:
    • Wen‑Hui Weng
    • Wai‑Hung Leung
    • Yeu Jye Pang
    • Li‑Wei Kuo
    • Hsi‑Hsien Hsu
  • View Affiliations / Copyright

    Affiliations: Department of Chemical Engineering and Biotechnology, Graduate Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology, Taipei 10608, Taiwan, R.O.C., Department of Internal Medicine, Queen Elizabeth The Queen Mother Hospital, Margate CT9 4AN, UK, Division of Colorectal Surgery, Department of Surgery, Mackay Memorial Hospital, Taipei 10491, Taiwan, R.O.C.
  • Pages: 6188-6194
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    Published online on: September 5, 2018
       https://doi.org/10.3892/ol.2018.9408
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Abstract

It is known that colorectal cancer (CRC) cells containing mutations of the genes KRAS and BRAF are predominate mechanisms causing resistance to epidermal growth factor receptor (EGFR) inhibitors, and commonly exhibit a lower expression of microRNA‑378 (miR‑378) when compared with the wild type. In the present study, the aim was to determine the possible mechanism which associates miR‑378 with the mitogen‑activated protein kinase pathway, and to determine the efficiency of eicosapentaenoic acid ethyl ester (EPA) in its ability to restore sensitivity towards cetuximab, an EGFR inhibitor. The results demonstrated that a combined treatment of 40 µM EPA with 0.2 µM cetuximab can significantly suppress the cell growth in KRAS‑mutant and control wild‑type cells. Furthermore, the higher phosphorylated protein level of extracellular‑signal‑regulated kinase 1/2 was notable in KRAS EPA‑treated cells (P=0.006‑0.047) and resulted in significantly increased cell death; however, inconsistent results were indicated in EPA‑treated BRAF‑mutant cells, compared with the original cells (without treatment). KRAS‑mutant and wild‑type Caco‑2 cells treated with EPA exhibited increased cetuximab response rates, but these response rates were reduced in the BRAF‑mutant cells. In conclusion, upregulation of miR‑378 induced by EPA may result in the significant restoration of sensitivity to cetuximab in the KRAS‑mutant cells. The present data will contribute to a notable potential therapeutic solution for future clinical CRC treatments.
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View References

1 

Lièvre A, Bachet JP, Le Corre D, Boige V, Landi B, Emile JF, Côté JF, Tomasic G, Penna C, Ducreux M, et al: KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 66:3992–3995. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Bokemeyer C, Bondarenko I, Makhson A, Hartmann JT, Aparicio J, de Braud F, Donea S, Ludwig H, Schuch G, Stroh C, et al: Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol. 27:663–671. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Van Cutsem E, Köhne CH, Hitre E, Zaluski J, Chien Chang CR, Makhson A, D'Haens G, Pintér T, Lim R, Bodoky G, et al: Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. NEJM. 360:1408–1417. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Tol J, Nagtegaal ID and Punt CJ: BRAF mutation in metastatic colorectal cancer. NEJM. 361:98–99. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Di Nicolantonio F, Martini M, Molinari F, Sartore-Bianchi A, Arena S, Saletti P, De Dosso S, Mazzucchelli L, Frattini M, Siena S and Bardelli A: Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol. 26:5705–5712. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Baldus SE, Schaefer KL, Engers R, Hartleb D, Stoecklein NH and Gabbert HE: Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases. Clin Cancer Res. 16:790–799. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Di Fiore F, Blanchard F, Charbonnier F, Le Pessot F, Lamy A, Galais MP, Bastit L, Killian A, Sesboüé R, Tuech JJ, et al: Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy. Br J Cancer. 96:1166–1169. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Frattini M, Saletti P, Romagnani E, Martin V, Molinari F, Ghisletta M, Camponovo A, Etienne LL, Cavalli F and Mazzucchelli L: PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br J Cancer. 97:1139–1145. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, Juan T, Sikorski R, Suggs S, Radinsky R, et al: Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol. 26:1626–1634. 2008. View Article : Google Scholar : PubMed/NCBI

10 

De Roock W, Piessevaux H, De Schutter J, Janssens M, De Hertogh G, Personeni N, Biesmans B, Van Laethem JL, Peeters M, Humblet Y, et al: KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann Oncol. 19:508–515. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Van Cutsem E, Köhne CH, Láng I, Folprecht G, Nowacki MP, Cascinu S, Shchepotin I, Maurel J, Cunningham D, Tejpar S, et al: Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol. 29:2011–2019. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Watzinger F, Mayr B, Haring E and Lion T: High sequence similarity within ras exons 1 and 2 in different mammalian species and phylogenetic divergence of the ras gene family. Mamm Genome. 9:214–219. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Andreyev HJ, Ross PJ, Cunningham D and Clarke PA: Antisense treatment directed against mutated Ki-ras in human colorectal adenocarcinoma. Gut. 48:230–237. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Bazan V, Migliavacca M, Zanna I, Tubiolo C, Grassi N, Latteri MA, La Farina M, Albanese I, Dardanoni G, Salerno S, et al: Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype. Ann Oncol. 13:1438–1446. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, Zanon C, Moroni M, Veronese S, Siena S and Bardelli A: Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res. 67:2643–2648. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Esteller M, Gonzalez S, Risques RA, Marcuello E, Mangues R, Germà JR, Herman JG, Capellà G and Peinado MA: K-ras and p16 aberrations confer poor prognosis in human colorectal cancer. J Clin Oncol. 19:299–304. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Roskoski R Jr: RAF protein-serine/threonine kinases: Structure and regulation. Biochem Biophys Res Commun. 399:313–317. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Pakneshan S, Salajegheh A, Smith RA and Lam AK: Clinicopathological relevance of BRAF mutations in human cancer. Pathology. 45:346–356. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Deng G, Bell I, Crawley S, Gum J, Terdiman JP, Allen BA, Truta B, Sleisenger MH and Kim YS: BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. Clin Cancer Res. 10:191–195. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Callari M, Dugo M, Musella V, Marchesi E, Chiorino G, Grand MM, Pierotti MA, Daidone MG, Canevari S and De Cecco L: Comparison of microarray platforms for measuring differential microRNA expression in paired normal/cancer colon tissues. PLoS One. 7:e451052012. View Article : Google Scholar : PubMed/NCBI

21 

Faltejskova P, Svoboda M, Srutova K, Mlcochova J, Besse A, Nekvindova J, Radova L, Fabian P, Slaba K, Kiss I, et al: Identification and functional screening of microRNAs highly deregulated in colorectal cancer. J Cell Mol Med. 16:2655–2666. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Mosakhani N, Sarhadi VK, Borze I, Karjalainen-Lindsberg ML, Sundström J, Ristamäki R, Osterlund P and Knuutila S: MicroRNA profiling differentiates colorectal cancer according to KRAS status. Genes Chromosomes Cancer. 51:1–9. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Wang YX, Zhang XY, Zhang BF, Yang CQ, Chen XM and Gao HJ: Initial study of microRNA expression profiles of colonic cancer without lymph node metastasis. J Dig Dis. 11:50–54. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Ganesan J, Ramanujam D, Sassi Y, Ahles A, Jentzsch C, Werfel S, Leierseder S, Loyer X, Giacca M, Zentilin L, et al: MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors. Circulation. 127:2097–2106. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Weng WH, Leung WH, Pang YJ and Hsu HH: Lauric acid can improve the sensitization of cetuximab in KRA/BRAF mutated colorectal cancer cells by retrivable microRNA-378 expression. Oncol Rep. 35:107–116. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Feng M, Li Z, Aau M, Wong CH, Yang X and Yu Q: Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation. Oncogene. 30:2242–2251. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Carrer M, Liu N, Grueter CE, Williams AH, Frisard MI, Hulver MW, Bassel-Duby R and Olson EN: Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*. Proc Natl Acad Sci USA. 109:15330–15335. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Chambers KT, Chen Z, Crawford PA, Fu X, Burgess SC, Lai L, Leone TC, Kelly DP and Finck BN: Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding. PLoS One. 7:e526452012. View Article : Google Scholar : PubMed/NCBI

29 

Gerin I, Bommer GT, McCoin CS, Sousa KM, Krishnan V and MacDougald OA: Roles for miRNA-378/378* in adipocyte gene expression and lipogenesis. Am J Physiol Endocrinol Metab. 299:E198–E206. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC and Patti ME: Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: Potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem. 282:15439–15450. 2007. View Article : Google Scholar : PubMed/NCBI

31 

EFSA: Scientific option on the tolerable upper intake level of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (EPA). European Food Safety Authority Journal. 10:28152012.

32 

Ijzerman RG, Stehouwer CD, Serné EH, Voordouw JJ, Smulders YM, Delemarre-van de Waal HA and van Weissenbruch MM: Incorporation of the fasting free fatty acid concentration into quantitative insulin sensitivity check index improves its association with insulin sensitivity in adults, but not in children. Eur J Endocrinol. 160:59–64. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Mensink RP, Zock PL, Kester AD and Katan MB: Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: A meta-analysis of 60 controlled trials. Am J Clin Nutr. 77:1146–1155. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Giros A, Grzybowski M, Sohn VR, Pons E, Fernandez-Morales J, Xicola RM, Sethi P, Grzybowski J, Goel A, Boland CR, Gassull MA, Llor X, et al: Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids Docosahexaenoic and Eicosapentaenoic. Cancer Prev Res (Phila). 2:732–742. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Fukui M, Kang KS, Okada K and Zhu BT: EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: Role of ROS accumulation, caspase-8 activation, and autophagy induction. J Cell Biochem. 114:192–203. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Nikolakopoulou Z, Nteliopoulos G, Michael-Titus AT and Parkinson EK: Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2. Carcinogenesis. 34:2716–2725. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Ding N, Sun X, Wang T, Huang L, Wen J and Zhou Y: miR-378a-3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10. Int J Mol Med. 42:381–391. 2018.PubMed/NCBI

38 

Bai B, Liu H and Laiho M: Small RNA expression and deep sequencing analyses of the nucleolus reveal the presence of nucleolus-associated microRNAs. FEBS Open Bio. 4:441–449. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Livak KJ and Schmittgen TD.: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

40 

Yang L, Su T, Lv D, Xie F, Liu W, Cao J, Sheikh IA, Qin X, Li L and Chen L: ERK1/2 mediates lung adenocarcinoma cell proliferation and autophagy induced by apelin-13. Acta Biochmm Biophys Sin (Shanghai). 46:100–111. 2014. View Article : Google Scholar

41 

Randhawa H, Kibble K, Zeng H, Moyer MP and Reindl KM: Activation of ERK signaling and induction of colon cancer cell death by piperlongumine. Toxicol In Vitro. 27:1626–1633. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Liu Y, Yang Y, Ye YC, Shi QF, Chai K, Tashiro S, Onodera S and Ikejima T: Activation of ERK-p53 and ERK-mediated phosphorylation of Bcl-2 are involved in autophagic cell death induced by the c-Met inhibitor SU11274 in human lung cancer A549 cells. J Pharmacol Sci. 118:423–432. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Singh S, Upadhyay AK, Ajay AK and Bhat MK: p53 regulates ERK activation in carboplatin induced apoptosis in cervical carcinoma: A novel target of p53 in apoptosis. FEBS Lett. 581:289–295. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Schweyer S, Soruri A, Meschter O, Heintze A, Zschunke F, Miosge N, Thelen P, Schlott T, Radzun HJ and Fayyazi A: Cisplatin-induced apoptosis in human malignant testicular germ cell lines depends on MEK/ERK activation. Br J Cancer. 91:589–598. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Liu W, Ren H, Ren J, Yin T, Hu B, Xie S, Dai Y, Wu W, Xiao Z, Yang X and Xie D: The role of EGFR/PI3K/Akt/cyclinD1 signaling pathway in acquired middle ear cholesteatoma. Mediators Inflamm. 2013:6512072013. View Article : Google Scholar : PubMed/NCBI

46 

Lo HW and Hung MC: Nuclear EGFR signalling network in cancers: Linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival. Br J Cancer. 94:184–188. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Weng WH, Leung WH, Pang YJ, Kuo LW and Hsu HH: EPA significantly improves anti‑EGFR targeted therapy by regulating miR‑378 expression in colorectal cancer. Oncol Lett 16: 6188-6194, 2018.
APA
Weng, W., Leung, W., Pang, Y.J., Kuo, L., & Hsu, H. (2018). EPA significantly improves anti‑EGFR targeted therapy by regulating miR‑378 expression in colorectal cancer. Oncology Letters, 16, 6188-6194. https://doi.org/10.3892/ol.2018.9408
MLA
Weng, W., Leung, W., Pang, Y. J., Kuo, L., Hsu, H."EPA significantly improves anti‑EGFR targeted therapy by regulating miR‑378 expression in colorectal cancer". Oncology Letters 16.5 (2018): 6188-6194.
Chicago
Weng, W., Leung, W., Pang, Y. J., Kuo, L., Hsu, H."EPA significantly improves anti‑EGFR targeted therapy by regulating miR‑378 expression in colorectal cancer". Oncology Letters 16, no. 5 (2018): 6188-6194. https://doi.org/10.3892/ol.2018.9408
Copy and paste a formatted citation
x
Spandidos Publications style
Weng WH, Leung WH, Pang YJ, Kuo LW and Hsu HH: EPA significantly improves anti‑EGFR targeted therapy by regulating miR‑378 expression in colorectal cancer. Oncol Lett 16: 6188-6194, 2018.
APA
Weng, W., Leung, W., Pang, Y.J., Kuo, L., & Hsu, H. (2018). EPA significantly improves anti‑EGFR targeted therapy by regulating miR‑378 expression in colorectal cancer. Oncology Letters, 16, 6188-6194. https://doi.org/10.3892/ol.2018.9408
MLA
Weng, W., Leung, W., Pang, Y. J., Kuo, L., Hsu, H."EPA significantly improves anti‑EGFR targeted therapy by regulating miR‑378 expression in colorectal cancer". Oncology Letters 16.5 (2018): 6188-6194.
Chicago
Weng, W., Leung, W., Pang, Y. J., Kuo, L., Hsu, H."EPA significantly improves anti‑EGFR targeted therapy by regulating miR‑378 expression in colorectal cancer". Oncology Letters 16, no. 5 (2018): 6188-6194. https://doi.org/10.3892/ol.2018.9408
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