Expression of circ_001569 is upregulated in osteosarcoma and promotes cell proliferation and cisplatin resistance by activating the Wnt/β‑catenin signaling pathway

Zhang,Hongfei; Yan,Jiapeng; Lang,Xujian; Zhuang,Yuesheng

doi:10.3892/ol.2018.9410

Expression of circ_001569 is upregulated in osteosarcoma and promotes cell proliferation and cisplatin resistance by activating the Wnt/β‑catenin signaling pathway

Authors:
- Hongfei Zhang
- Jiapeng Yan
- Xujian Lang
- Yuesheng Zhuang
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Affiliations: Department of Orthopedics, Affiliated Hospital of Weifang Medical University, Kuiwen, Weifang, Shandong 261031, P.R. China
Published online on: September 6, 2018 https://doi.org/10.3892/ol.2018.9410
Pages: 5856-5862
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circular RNAs (circRNAs), a type of non‑coding RNAs derived from back‑splicing, have been reported to function as gene expression regulators involved in tumor development of multiple human tumors. However, the clinical significance and underlying molecular mechanisms of circ_001569 in osteosarcoma still be unknown. In the study, we found that circ_001569 expression was significantly overexpressed in osteosarcoma tissues compared with adjacent noncancerous bone tissues. Higher circ_001569 expression significantly correlated with distant metastasis and advanced tumor stage of osteosarcoma patients. Gain‑function and loss‑function assays showed that circ_001569 knockdown significantly inhibited osteosarcoma cell proliferation and cell colon formation capacities. Moreover, upregulation of circ_001569 significantly promoted osteosarcoma cell resistance to cisplatin by activating Wnt/β‑catenin signaling pathway. Thus, these results indicated that circ_001569 represented a novel potentially therapeutic target of osteosarcoma.

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