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Relationship between CT signs and the expression of miR‑146a in colon cancer

  • Authors:
    • Zijian Liu
    • Yuzhu Li
    • Quanxiang Luo
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology, Yingcheng Hospital, The Second Hospital of Shandong University in Zhaoyuan City, Zhaoyuan, Shandong 265400, P.R. China, Department of General Surgery, The People's Hospital of Zhaoyuan City, Zhaoyuan, Shandong 265400, P.R. China, Imaging Center, Yingcheng Hospital, The Second Hospital of Shandong University in Zhaoyuan City, Zhaoyuan, Shandong 265400, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6598-6602
    |
    Published online on: September 7, 2018
       https://doi.org/10.3892/ol.2018.9415
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Abstract

Our study investigated the relationship between CT signs of colon cancer and the expression of miR‑146a, to evaluate their predictive value in early diagnosis and of colon cancer. A total of 216 patients with colon cancer who were admitted to the Department of Hematology and Oncology in Yingcheng Hospital, the Second Hospital of Shandong University in Zhaoyuan City from January 2013 to March 2017 were selected as the study group. At the same time, 150 patients with benign colitis were also included to serve as the control group. CT scan was performed for patients in both the study and control groups. The expression of miR‑146a in serum of patients in the study and control groups was detected by RT‑qPCR, and of CT signs and miR‑146a expression were analyzed. The relative expression level of miR‑146a in peripheral blood of study group was significantly lower than that of the control group (t=12.180, p=0.001). Sensitivity and specificity of combined detection of CT and miR‑146a in the study and control groups were 91.4 and 93.6%, respectively, which were higher than those of the single test (p<0.05). Among CT signs of study group, luminal wall, cavity and diameter changes, as well as size of tumor and surrounding tissues showed no significant correlation with the expression of miR‑146a (p>0.05). The expression level of miR‑146a in patients with high‑risk of invasion was significantly higher than that in patients with low‑risk of invasion (t=4.791, p=0.001). The expression level of miR‑146a in lymph node metastasis was significantly lower than that in non‑lymph node metastasis (t=3.104, p=0.002). miR‑146a may be involved in the development and progression of colon cancer. Combined detection of CT and miR‑146a may enhance the sensitivity and specificity of the diagnosis of colon cancer, and may provide a good predictive value for invasion and metastasis of colon cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Z, Li Y and Luo Q: Relationship between CT signs and the expression of miR‑146a in colon cancer. Oncol Lett 16: 6598-6602, 2018.
APA
Liu, Z., Li, Y., & Luo, Q. (2018). Relationship between CT signs and the expression of miR‑146a in colon cancer. Oncology Letters, 16, 6598-6602. https://doi.org/10.3892/ol.2018.9415
MLA
Liu, Z., Li, Y., Luo, Q."Relationship between CT signs and the expression of miR‑146a in colon cancer". Oncology Letters 16.5 (2018): 6598-6602.
Chicago
Liu, Z., Li, Y., Luo, Q."Relationship between CT signs and the expression of miR‑146a in colon cancer". Oncology Letters 16, no. 5 (2018): 6598-6602. https://doi.org/10.3892/ol.2018.9415
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z, Li Y and Luo Q: Relationship between CT signs and the expression of miR‑146a in colon cancer. Oncol Lett 16: 6598-6602, 2018.
APA
Liu, Z., Li, Y., & Luo, Q. (2018). Relationship between CT signs and the expression of miR‑146a in colon cancer. Oncology Letters, 16, 6598-6602. https://doi.org/10.3892/ol.2018.9415
MLA
Liu, Z., Li, Y., Luo, Q."Relationship between CT signs and the expression of miR‑146a in colon cancer". Oncology Letters 16.5 (2018): 6598-6602.
Chicago
Liu, Z., Li, Y., Luo, Q."Relationship between CT signs and the expression of miR‑146a in colon cancer". Oncology Letters 16, no. 5 (2018): 6598-6602. https://doi.org/10.3892/ol.2018.9415
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