Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2018 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2018 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Imbalanced expression pattern of steroid receptor coactivator‑1 and ‑3 in liver cancer compared with normal liver: An immunohistochemical study with tissue microarray

  • Authors:
    • Shan Li
    • Huiyan Zhang
    • Yanlan Yu
    • Mengying Liu
    • Deyu Guo
    • Xuqing Zhang
    • Jiqiang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing 400038, P.R. China, Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China, Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6339-6348
    |
    Published online on: September 17, 2018
       https://doi.org/10.3892/ol.2018.9443
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Steroids affect normal and pathological functions of the liver through receptors, which require coactivators for their transcriptional activation. Steroid receptor coactivator (SRC)‑1 and SRC‑3 have been demonstrated to be regulated in numerous cancers; however, their expression profiles in liver cancer including hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCC) remain unclear. Using tissue microarray immunohistochemistry, normal liver tissue and HCC tissue exhibited immunoreactivity of SRC‑1, which were predominantly localized within extranuclear components; in CCC, they were detected within the cell nuclei; SRC‑3 was also detected in the cell nuclei. Furthermore, no altered expression of SRC‑1 and SRC‑3 was observed in liver cancer compared with normal liver tissue; however, in CCC, the expression of SRC‑3 was significantly increased compared with that detected in HCC. Importantly, although expression of SRC‑1 and SRC‑3 did not reveal any significant differences (30 vs. 40%) in normal liver tissue, HCC and CCC expression of SRC‑1 was significantly decreased compared with that of SRC‑3 (9.3 vs. 36%, and 6.7 vs. 67.7% for HCC and CCC, respectively). Further comparative analysis revealed that this discrepancy was detected in males with liver cancer, across all ages of HCC cases, younger CCC cases and all stages of liver cancer. The results suggested the presence of an imbalanced expression pattern of SRC‑1 and SRC‑3 from normal liver tissue to liver cancer (decreased SRC‑1 and increased SRC‑3), which may affect hepatic function and therefore promote liver carcinogenesis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Simpson E and Santen RJ: Celebrating 75 years of oestradiol. J Mol Endocrinol. 55:T1–T20. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Brady CW: Liver disease in menopause. World J Gastroenterol. 21:7613–7620. 2015. View Article : Google Scholar : PubMed/NCBI

3 

McGlynn KA, Sahasrabuddhe VV, Campbell PT, Graubard BI, Chen J, Schwartz LM, Petrick JL, Alavanja MC, Andreotti G, Boggs DA, et al: Reproductive factors, exogenous hormone use and risk of hepatocellular carcinoma among US women: Results from the liver cancer pooling project. Br J Cancer. 112:1266–1272. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Yang D, Hanna DL, Usher J, LoCoco J, Chaudhari P, Lenz HJ, Setiawan VW and El-Khoueiry A: Impact of sex on the survival of patients with hepatocellular carcinoma: A surveillance, epidemiology, and end results analysis. Cancer. 120:3707–3716. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Kanda T, Jiang X and Yokosuka O: Androgen receptor signaling in hepatocellular carcinoma and pancreatic cancers. World J Gastroenterol. 20:9229–9236. 2014.PubMed/NCBI

6 

Kelly DM, Nettleship JE, Akhtar S, Muraleedharan V, Sellers DJ, Brooke JC, McLaren DS, Channer KS and Jones TH: Testosterone suppresses the expression of regulatory enzymes of fatty acid synthesis and protects against hepatic steatosis in cholesterol-fed androgen deficient mice. Life Sci. 109:95–103. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Biegon A, Alexoff DL, Kim SW, Logan J, Pareto D, Schlyer D, Wang GJ and Fowler JS: Aromatase imaging with [N-methyl-11C]vorozole PET in healthy men and women. J Nucl Med. 56:580–585. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Hata S, Miki Y, Saito R, Ishida K, Watanabe M and Sasano H: Aromatase in human liver and its diseases. Cancer Med. 2:305–315. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Van Sinderen ML, Steinberg GR, Jørgensen SB, To SQ, Knower KC, Clyne CD, Honeyman J, Chow JD, Herridge KA, Jones ME, et al: Hepatic glucose intolerance precedes hepatic steatosis in the male aromatase knockout (ArKO) mouse. PloS One. 9:e872302014. View Article : Google Scholar : PubMed/NCBI

10 

Sinclair M, Gow PJ, Angus PW, Hoermann R, Handelsman DJ, Wittert G, Martin S and Grossmann M: High circulating estrone and low testosterone correlate with adverse clinical outcomes in men with advanced liver disease. Liver Int. 36:1619–1627. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Qian X, Zhan Q, Lv L, Zhang H, Hong Z, Li Y, Xu H, Chai Y, Zhao L and Zhang G: Steroid hormone profiles plus α-fetoprotein for diagnosing primary liver cancer by liquid chromatography tandem mass spectrometry. Clin Chim Acta. 457:92–98. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Wei Q, Guo P, Mu K, Zhang Y, Zhao W, Huai W, Qiu Y, Li T, Ma X, Liu Y, et al: Estrogen suppresses hepatocellular carcinoma cells through ERβ-mediated upregulation of the NLRP3 inflammasome. Lab Invest. 95:804–816. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Baldissera VD, Alves AF, Almeida S, Porawski M and Giovenardi M: Hepatocellular carcinoma and estrogen receptors: Polymorphisms and isoforms relations and implications. Med Hypotheses. 86:67–70. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Shen M and Shi H: Sex hormones and their receptors regulate liver energy homeostasis. Int J Endocrinol. 2015:2942782015. View Article : Google Scholar : PubMed/NCBI

15 

Sheng ML, Xu GL, Zhang CH, Jia WD, Ren WH, Liu WB, Zhou T, Wang YC, Lu ZL, Liu WF, et al: Aberrant estrogen receptor alpha expression correlates with hepatocellular carcinoma metastasis and its mechanisms. Hepatogastroenterology. 61:146–150. 2014.PubMed/NCBI

16 

Ahmed HH, Shousha WG, Shalby AB, El-Mezayen HA, Ismaiel NN and Mahmoud NS: Implications of sex hormone receptor gene expression in the predominance of hepatocellular carcinoma in males: Role of natural products. Asian Pac J Cancer Prev. 16:4949–4954. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Wang B, Chen L and Chang HT: Potential diagnostic and prognostic biomarkers for cholangiocarcinoma in serum and bile. Biomark Med. 10:613–619. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Isse K, Specht SM, Lunz JG III, Kang LI, Mizuguchi Y and Demetris AJ: Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans. Hepatology. 51:869–880. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Hunsawong T, Singsuksawat E, In-chon N, Chawengrattanachot W, Thuwajit C, Sripa B, Paupairoj A, Chau-in S and Thuwajit P: Estrogen is increased in male cholangiocarcinoma patients' serum and stimulates invasion in cholangiocarcinoma cell lines in vitro. J Cancer Res Clin Oncol. 138:1311–1320. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Singsuksawat E, Thuwajit C, Charngkaew K and Thuwajit P: Increased ETV4 expression correlates with estrogen-enhanced proliferation and invasiveness of cholangiocarcinoma cells. Cancer Cell Int. 18:252018. View Article : Google Scholar : PubMed/NCBI

21 

Marzioni M, Torrice A, Saccomanno S, Rychlicki C, Agostinelli L, Pierantonelli I, Rhönnstad P, Trozzi L, Apelqvist T, Gentile R, et al: An oestrogen receptor β-selective agonist exerts anti-neoplastic effects in experimental intrahepatic cholangiocarcinoma. Dig Liver Dis. 44:134–142. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Xu J and Li Q: Review of the in vivo functions of the p160 steroid receptor coactivator family. Mol Endocrinol. 17:1681–1692. 2003. View Article : Google Scholar : PubMed/NCBI

23 

York B and O'Malley BW: Steroid receptor coactivator (SRC) family: Masters of systems biology. J Biol Chem. 285:38743–38750. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Xu J, Wu RC and O'Malley BW: Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nat Rev Cancer. 9:615–630. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Qin L, Liu Z, Chen H and Xu J: The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis. Cancer Res. 69:3819–3827. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Qin L, Chen X, Wu Y, Feng Z, He T, Wang L, Liao L and Xu J: Steroid receptor coactivator-1 upregulates integrin α5 expression to promote breast cancer cell adhesion and migration. Cancer Res. 71:1742–1751. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Zhang Y, Duan C, Bian C, Xiong Y and Zhang J: Steroid receptor coactivator-1: A versatile regulator and promising therapeutic target for breast cancer. J Steroid Biochem Mol Biol. 138:17–23. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Song X, Zhang C, Zhao M, Chen H, Liu X, Chen J, Lonard DM, Qin L, Xu J, Wang X, et al: Steroid receptor coactivator-3 (SRC-3/AIB1) as a novel therapeutic target in triple negative breast cancer and its inhibition with a phospho-bufalin prodrug. PLoS One. 10:e01400112015. View Article : Google Scholar : PubMed/NCBI

29 

Wang H, Zhang D, Wu W, Zhang J, Guo D, Wang Q, Jing T, Xu C, Bian X and Yang K: Overexpression and gender-specific differences of SRC-3 (SRC-3/AIB1) immunoreactivity in human non-small cell lung cancer: An in vivo study. J Histochem Cytochem. 58:1121–1127. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Luo F, Li W, Zhang J, Huang K, Fu J and Xie Z: Overexpression of steroid receptor coactivator-3 in bone cancers: An in vivo immunohistochemical study with tissue microarray. Pathol Res Pract. 209:790–796. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Li W, Fu J, Bian C, Zhang J and Xie Z: Immunohistochemical localization of steroid receptor coactivators in chondrosarcoma: An in vivo tissue microarray study. Pathol Res Pract. 210:1005–1010. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Liu C, Zhang Y, Zhang K, Bian C, Zhao Y and Zhang J: Expression of estrogen receptors, androgen receptor and steroid receptor coactivator-3 is negatively correlated to the differentiation of astrocytic tumors. Cancer Epidemiol. 38:291–297. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Liu M, Zhang K, Zhao Y, Guo Q, Guo D and Zhang J: Evidence for involvement of steroid receptors and coactivators in neuroepithelial and meningothelial tumors. Tumour Biol. 36:3251–3261. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Jeong JW, Kwak I, Lee KY, White LD, Wang XP, Brunicardi FC, O'Malley BW and DeMayo FJ: The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolism. Mol Endocrinol. 20:1138–1152. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Louet JF, Chopra AR, Sagen JV, An J, York B, Tannour-Louet M, Saha PK, Stevens RD, Wenner BR, Ilkayeva OR, et al: The coactivator SRC-1 is an essential coordinator of hepatic glucose production. Cell Metab. 12:606–618. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Motamed M, Rajapakshe KI, Hartig SM, Coarfa C, Moses RE, Lonard DM and O'Malley BW: Steroid receptor coactivator 1 is an integrator of glucose and NAD+/NADH homeostasis. Mol Endocrinol. 28:395–405. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Tannour-Louet M, York B, Tang K, Stashi E, Bouguerra H, Zhou S, Yu H, Wong LJ, Stevens RD, Xu J, et al: Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis. Mol Endocrinol. 28:1707–1718. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Hansel MC, Davila JC, Vosough M, Gramignoli R, Skvorak KJ, Dorko K, Marongiu F, Blake W and Strom SC: The use of induced pluripotent stem cells for the study and treatment of liver diseases. Curr Protoc Toxicol. 67:14 13 11–14 13 27. 2016.

39 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Zhang D, Guo Q, Bian C, Zhang J, Lin S and Su B: Alterations of steroid receptor coactivator-1 (SRC-1) immunoreactivities in specific brain regions of young and middle-aged female Sprague-Dawley rats. Brain Res. 1382:88–97. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM and Meltzer PS: AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science. 277:965–968. 1997. View Article : Google Scholar : PubMed/NCBI

43 

Culig Z, Klocker H, Bartsch G and Hobisch A: Androgen receptors in prostate cancer. Endocr Relat Cancer. 9:155–170. 2002. View Article : Google Scholar : PubMed/NCBI

44 

Kershah SM, Desouki MM, Koterba KL and Rowan BG: Expression of estrogen receptor coregulators in normal and malignant human endometrium. Gynecol Oncol. 92:304–313. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Xie D, Sham JS, Zeng WF, Lin HL, Bi J, Che LH, Hu L, Zeng YX and Guan XY: Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma. Hum Pathol. 36:777–783. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Glaeser M, Floetotto T, Hanstein B, Beckmann MW and Niederacher D: Gene amplification and expression of the steroid receptor coactivator SRC3 (AIB1) in sporadic breast and endometrial carcinomas. Horm Metab Res. 33:121–126. 2001. View Article : Google Scholar : PubMed/NCBI

47 

Xu FP, Xie D, Wen JM, Wu HX, Liu YD, Bi J, Lv ZL, Zeng YX and Guan XY: SRC-3/AIB1 protein and gene amplification levels in human esophageal squamous cell carcinomas. Cancer Lett. 245:69–74. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Sakakura C, Hagiwara A, Yasuoka R, Fujita Y, Nakanishi M, Masuda K, Kimura A, Nakamura Y, Inazawa J, Abe T and Yamagishi H: Amplification and over-expression of the AIB1 nuclear receptor co-activator gene in primary gastric cancers. Int J Cancer. 89:217–223. 2000. View Article : Google Scholar : PubMed/NCBI

49 

Yoshida H, Liu J, Samuel S, Cheng W, Rosen D and Naora H: Steroid receptor coactivator-3, a homolog of Taiman that controls cell migration in the Drosophila ovary, regulates migration of human ovarian cancer cells. Mol Cell Endocrinol. 245:77–85. 2005. View Article : Google Scholar : PubMed/NCBI

50 

Henke RT, Haddad BR, Kim SE, Rone JD, Mani A, Jessup JM, Wellstein A, Maitra A and Riegel AT: Overexpression of the nuclear receptor coactivator AIB1 (SRC-3) during progression of pancreatic adenocarcinoma. Clin Cancer Res. 10:6134–6142. 2004. View Article : Google Scholar : PubMed/NCBI

51 

Uchikawa J, Shiozawa T, Shih HC, Miyamoto T, Feng YZ, Kashima H, Oka K and Konishi I: Expression of steroid receptor coactivators and corepressors in human endometrial hyperplasia and carcinoma with relevance to steroid receptors and Ki-67 expression. Cancer. 98:2207–2213. 2003. View Article : Google Scholar : PubMed/NCBI

52 

Martínez-Jiménez CP, Gómez-Lechón MJ, Castell JV and Jover R: Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells. J Biol Chem. 281:29840–29849. 2006. View Article : Google Scholar : PubMed/NCBI

53 

Tong Z, Li M, Wang W, Mo P, Yu L, Liu K, Ren W, Li W, Zhang H, Xu J and Yu C: Steroid receptor coactivator 1 promotes human hepatocellular carcinoma progression by enhancing Wnt/β-catenin signaling. J Biol Chem. 290:18596–18608. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Ma X, Xu L, Wang S, Cui B, Li X, Xu J and Ning G: Deletion of steroid receptor coactivator-3 gene ameliorates hepatic steatosis. J Hepatol. 55:445–452. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li S, Zhang H, Yu Y, Liu M, Guo D, Zhang X and Zhang J: Imbalanced expression pattern of steroid receptor coactivator‑1 and ‑3 in liver cancer compared with normal liver: An immunohistochemical study with tissue microarray. Oncol Lett 16: 6339-6348, 2018.
APA
Li, S., Zhang, H., Yu, Y., Liu, M., Guo, D., Zhang, X., & Zhang, J. (2018). Imbalanced expression pattern of steroid receptor coactivator‑1 and ‑3 in liver cancer compared with normal liver: An immunohistochemical study with tissue microarray. Oncology Letters, 16, 6339-6348. https://doi.org/10.3892/ol.2018.9443
MLA
Li, S., Zhang, H., Yu, Y., Liu, M., Guo, D., Zhang, X., Zhang, J."Imbalanced expression pattern of steroid receptor coactivator‑1 and ‑3 in liver cancer compared with normal liver: An immunohistochemical study with tissue microarray". Oncology Letters 16.5 (2018): 6339-6348.
Chicago
Li, S., Zhang, H., Yu, Y., Liu, M., Guo, D., Zhang, X., Zhang, J."Imbalanced expression pattern of steroid receptor coactivator‑1 and ‑3 in liver cancer compared with normal liver: An immunohistochemical study with tissue microarray". Oncology Letters 16, no. 5 (2018): 6339-6348. https://doi.org/10.3892/ol.2018.9443
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Zhang H, Yu Y, Liu M, Guo D, Zhang X and Zhang J: Imbalanced expression pattern of steroid receptor coactivator‑1 and ‑3 in liver cancer compared with normal liver: An immunohistochemical study with tissue microarray. Oncol Lett 16: 6339-6348, 2018.
APA
Li, S., Zhang, H., Yu, Y., Liu, M., Guo, D., Zhang, X., & Zhang, J. (2018). Imbalanced expression pattern of steroid receptor coactivator‑1 and ‑3 in liver cancer compared with normal liver: An immunohistochemical study with tissue microarray. Oncology Letters, 16, 6339-6348. https://doi.org/10.3892/ol.2018.9443
MLA
Li, S., Zhang, H., Yu, Y., Liu, M., Guo, D., Zhang, X., Zhang, J."Imbalanced expression pattern of steroid receptor coactivator‑1 and ‑3 in liver cancer compared with normal liver: An immunohistochemical study with tissue microarray". Oncology Letters 16.5 (2018): 6339-6348.
Chicago
Li, S., Zhang, H., Yu, Y., Liu, M., Guo, D., Zhang, X., Zhang, J."Imbalanced expression pattern of steroid receptor coactivator‑1 and ‑3 in liver cancer compared with normal liver: An immunohistochemical study with tissue microarray". Oncology Letters 16, no. 5 (2018): 6339-6348. https://doi.org/10.3892/ol.2018.9443
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team