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Upregulation of circRNA_0000285 serves as a prognostic biomarker for nasopharyngeal carcinoma and is involved in radiosensitivity

  • Authors:
    • Mingxia Shuai
    • Jangwei Hong
    • Donghai Huang
    • Xin Zhang
    • Yongquan Tian
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
    Copyright: © Shuai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6495-6501
    |
    Published online on: September 20, 2018
       https://doi.org/10.3892/ol.2018.9471
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Abstract

Despite significant medical advancement, nasopharyngeal carcinoma (NPC) remains one of the most difficult types of cancer to detect and treat. Circular RNA (circRNA) signatures may be used as prognostic and predictive factors for cancer. Previous studies indicated that the biological role of circular homeodomain interacting protein kinase 3 (HIPK3) has cancer type‑specificity. The HIPK3 gene locus formats three circRNA isoforms: circRNA_100783, circRNA_0000285 and circRNA_100782. However, their roles in NPC remain unknown. In the present study, whether these circRNAs could be used as a biomarker for NPC diagnosis and predicting treatment response was investigated. Reverse transcription‑quantitative polymerase chain reaction was performed to measure the levels of circRNA_100783, circRNA_0000285 and circRNA_100782 in NPC and adjacent tissues. In addition, the circRNA_0000285 levels were further confirmed in serum samples from patients with NPC and healthy controls. The results demonstrated that circRNA_0000285, but not circRNA_100782 and circRNA_100783, was significantly increased in NPC tissues and serum samples from patients with NPC, compared with adjacent tissues and serum samples from healthy controls, respectively. Furthermore, circRNA_0000285 expression was increased in patients with radioresistant NPC, compared with patients with radiosensitive NPC. Further analysis demonstrated that circRNA_0000285 was significantly associated with tumor size (P<0.001), differentiation (P=0.022), lymph node metastasis (P=0.035), distant metastasis (P=0.022) and Tumor‑Node‑Metastasis stage (P<0.001). Additionally, univariate and multivariate analyses indicated that circRNA_0000285 may be an independent prognostic factor for the outcome of patients with NPC. The present data indicated that circRNA_0000285 may be a novel biomarker for NPC and is involved in NPC radiosensitivity.
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Copy and paste a formatted citation
Spandidos Publications style
Shuai M, Hong J, Huang D, Zhang X and Tian Y: Upregulation of circRNA_0000285 serves as a prognostic biomarker for nasopharyngeal carcinoma and is involved in radiosensitivity. Oncol Lett 16: 6495-6501, 2018.
APA
Shuai, M., Hong, J., Huang, D., Zhang, X., & Tian, Y. (2018). Upregulation of circRNA_0000285 serves as a prognostic biomarker for nasopharyngeal carcinoma and is involved in radiosensitivity. Oncology Letters, 16, 6495-6501. https://doi.org/10.3892/ol.2018.9471
MLA
Shuai, M., Hong, J., Huang, D., Zhang, X., Tian, Y."Upregulation of circRNA_0000285 serves as a prognostic biomarker for nasopharyngeal carcinoma and is involved in radiosensitivity". Oncology Letters 16.5 (2018): 6495-6501.
Chicago
Shuai, M., Hong, J., Huang, D., Zhang, X., Tian, Y."Upregulation of circRNA_0000285 serves as a prognostic biomarker for nasopharyngeal carcinoma and is involved in radiosensitivity". Oncology Letters 16, no. 5 (2018): 6495-6501. https://doi.org/10.3892/ol.2018.9471
Copy and paste a formatted citation
x
Spandidos Publications style
Shuai M, Hong J, Huang D, Zhang X and Tian Y: Upregulation of circRNA_0000285 serves as a prognostic biomarker for nasopharyngeal carcinoma and is involved in radiosensitivity. Oncol Lett 16: 6495-6501, 2018.
APA
Shuai, M., Hong, J., Huang, D., Zhang, X., & Tian, Y. (2018). Upregulation of circRNA_0000285 serves as a prognostic biomarker for nasopharyngeal carcinoma and is involved in radiosensitivity. Oncology Letters, 16, 6495-6501. https://doi.org/10.3892/ol.2018.9471
MLA
Shuai, M., Hong, J., Huang, D., Zhang, X., Tian, Y."Upregulation of circRNA_0000285 serves as a prognostic biomarker for nasopharyngeal carcinoma and is involved in radiosensitivity". Oncology Letters 16.5 (2018): 6495-6501.
Chicago
Shuai, M., Hong, J., Huang, D., Zhang, X., Tian, Y."Upregulation of circRNA_0000285 serves as a prognostic biomarker for nasopharyngeal carcinoma and is involved in radiosensitivity". Oncology Letters 16, no. 5 (2018): 6495-6501. https://doi.org/10.3892/ol.2018.9471
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